Electrochemical nano-bio-sensing and bio/CMOS interfaces

1. For the final Grade, the students have of write an IEEE-style essay-paper (two column, max 3 pages, plus one of bibliography), with which they have to demonstrate they understanding about the course content. Hard deadline to submit is in 4 weeks from now, namely the 14 of July 2024. This essay-paper has to be submitted by email to sandro.carrarra@epfl.ch, together with all the solutions of the above-mentioned exercises proposed by the book.

2. This assay-paper needs to propose a solution to address the detection-need required student-by-student here below (please, search for your name). The proposed solution needs to address one of the electrical detection-techniques deeply-discussed during the course. Solutions with optical detections are not accepted.

3. This assay-paper is an ¨exercise of style¨ and, therefore, it might contain just hypothesis or assumptions. These need to be scientifically based on literature: e.g., if a certain sensitivity has been published for a similar target/probe biochemical-system, then the same sensitivity might be taken as assumption for the detection proposed by the student, with reference to the paper with similar system.

4. This assay-paper needs to report the typical concentration range of the target molecules for the proposed application. Then, the paper needs to contain and to explain the three layers that constitute the proposed Bio/CMOS interface: the bio, the nano, and the CMOS aspects need all to be explicitly mentioned and elaborated, each of them in a separated paper-sections. The bio part needs to be deeply explained in terms of the provided detection-technique and in terms of the proposed electrodes-functionalization. The nano part needs to be deeply explained in terms of the improved sensing performance. The CMOS part needs to be deeply explained in terms of the provided electronic frontend-functionality.

5. This assay-paper might be also written by student’ couples: two students max per paper. In such a case, the assay-paper needs to address the two detection-needs proposed individually to each of the two students. Therefore, in such a case, the assay-paper needs to propose a multi-panel detection system. In such a case, the assay-paper will be co-authored by the two students. Therefore, the acknowledgement paragraph of the paper needs to report who-has-done-what in contributing to the paper.

6. In case of any doubt or need for help, please, do not hesitate to send an email to sandro.carrarra@epfl.ch, to ask for further clarifications or to require advice to develop your work.