Oncology
BIO-392
Media
Introduction
De Palma+Constam
Zoom recordings (2021):
- What is cancer? (De Palma): tube.switch.ch/videos/08ac255f
- Introduction of Hallmarks (Constam): tube.switch.ch/videos/51be2038
- Lecture I - What is cancer? (De Palma) (File)
- Hallmarks of cancer review 2000 (File)
- Hallmarks of cancer review 2011 (File)
- Introduction of cancer hallmarks - Constam (File)
De Palma
Multi-step tumor progression
Tumor initiators and promoters
Zoom recording (from 2021): tube.switch.ch/videos/76c6b8c8
- Lecture II - Multistep tumor progression (File)
- Lecture II - Exercise - Cancer risk: a matter of bad luck? (File)
- Lecture II - Exercise - Questions (File)
- Lecture II - Exercise correction (counter arguments) (File)
Constam
Sustained proliferation I
Zoom recording (2021) (only for part 1): tube.switch.ch/videos/3YW2iUfhjw
(Note that part 2 is now a separate lecture with additional content next week for which there will be no recording)- Lecture III - Sustained proliferative signaling I (File)
- Sustained proliferation, I - Exercise (File)
- Sustained proliferation, I - Exercise (PDF) (File)
- Sustained proliferation, I - Exercise answers (File)
- Lecture IV - Sustained proliferative signaling II (File)
- Exercise - Sustained proliferative signaling II (File)
- Exercise - Sustained proliferative signaling II - PDF (File)
- Exercise answers - Sustained proliferation, II (File)
Tumor angiogenesis
Zoom (from 2021):
https://mediaspace.epfl.ch/media/Tumor+angiogenesis+-+De+Palma+%282021%29/0_8x7vp14y/29510
- Lecture V - Tumor angiogenesis (File)
- Lecture V - Exercise on tumor angiogenesis (File)
- Lecture V - Exercise correction (File)
25 March - 31 March
De Palma
Anti-angiogenic therapy
Zoom (from 2021):
https://mediaspace.epfl.ch/media/Anti-angiogenic%20therapy%20-%20De%20Palma%20(2021)/0_xdk64fvu
- Lecture VI - Anti-angiogenic therapy (File)
- Lecture VI - exercise (File)
- Lecture VI - Exercise correction (File)
- Lecture VII - Evading growth suppressors (File)
- Evading growth suppressors - Exercise (File)
- Evading growth suppressors - Exercise (PDF) (File)
- Evading growth suppressors - Exercise answers (File)
- Cancer research milestones (FYI) (File)
- FYI: PyMT model of breast cancer (Folder)
Constam
Enabling replicative immortality
Zoom recording (2021): tube.switch.ch/videos/Dgvfj9UtGZ
- Replicative senescence and telomeres
- Oncogene-induced premature cellular senescence
- Heterochromatin formation by hypophosphorylated RB1
- Regulation by CDKN2A, p53/p21 and TGF-β pathways
- Lecture VIII - Replicative immortality (File)
- Replicative immortality - Exercise (File)
- Replicative immortality - Exercise (PDF) (File)
- Replicative immortality - Exercise answers (File)
De Palma
Inflammation and cancer
- Inflammation & cancer (File)
- Exercise_Inflammation and cancer (File)
- Exercise correction_Inflammation and cancer (File)
De Palma
Genetic instability + INTERIM TEST (De Palma part - NOT EVALUATED)
Constam
Activating invasion and metastasis
Zoom recording (2021): https://api.cast.switch.ch/p/113/sp/11300/playManifest/entryId/0_eqjlok6e/format/url/protocol/https/flavorParamIds/6,7/video.mp4
- integrin-mediated adhesion
- cadherin switch (EMT)
- ECM remodeling
- Circulating tumor cells
- micrometastases and the role of MET in colonization
- Lecture - Invasion & Metastasis (File)
- Invasion & metastasis - Excercise (File)
- Invasion & metastasis - Excercise (PDF) (File)
- Invasion & metastasis - Excercise answers (File)
Constam
Cell survival signaling, and rescue of apoptosis by cancer drugs in development
- characeristic features of apoptosis
- regulation by death receptors, Bcl-2 family members, p53 and Akt/mTOR signaling
- Therapeutic opportunities and challenges: BH3-only mimetics and mTOR inhibitors
- Lecture XIII - Evading cell death (File)
- Apoptosis 101 movie, 5 min (re-uploaded) (File)
- Resisting cell death - Exercise (File)
- Resisting cell death - Exercise answers (File)
- Zoom recording (2021): https://api.cast.switch.ch/p/113/sp/11300/playManifest/entryId/0_3ppov87t/format/url/protocol/https/flavorParamIds/6,7/video.mp4 (URL)
De Palma
Anticancer therapies I
De Palma
Anticancer therapies II (immunotherapies)