Microbiology

BIO-372

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Course summary

"Le rôle des infiniment petits m'apparaissait infiniment grand"
- Louis Pasteur (1822 - 1895)


SCHEDULE: Wednesday 14:15-16:00 in room CE 1.106 (exercises)

                      Wednesday 16:15-18:00 in room CE 2 (lectures)

TEXTBOOK: Brock Biology of Microorganisms [15th Kindle edition], by Madigan MT, Bender KS, Buckley DH, Sattley WM, and Stahl DA, published by Benjamin Cummings © 2019.

SUPPLEMENTAL READING: Living at Micro Scale: the Unexpected Physics of Being Small, by Dusenberry DB, published by  Harvard University Press, Cambridge, MA USA © 2011.

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WEEK 01 : 2025.02.19 (14:15-16:00) INTRODUCTION (CE 1.106)

                     2025.02.19 (16:15-18:00) LECTURES (CE 2)

“LIVING AT MICRO SCALE”

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 1 "The Microbial World" (pp. 1-33).

SUPPLEMENTAL READING: Why size matters: from bacteria to blue whales, by Bonner JT, published by Princeton University Press, Princeton, NJ USA © 2006.

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WEEK 02 : 2025.02.26 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.02.26 (16:15-18:00) LECTURES (CE 2)

“BIOMECHANICS OF THE BACTERIAL CELL ENVELOPE”

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 2 "Microbial Cell Structure and Function" Section I "Cells of Bacteria and Archaea" (pp. 34-39) and Section II "The Cell Membrane and Wall" (pp. 39-48).

SUPPLEMENTAL READING: Morris et al. (2008) Toward a biomechanical understanding of whole bacterial cells. Annu Rev Biochem 77: 583-613 PMID: 18355161.

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WEEK 03 : 2025.03.05 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.03.05 (16:15-18:00) LECTURES (CE 2)

“BIOMECHANICS OF THE BACTERIAL CYTOSKELETON”

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 7 "Molecular Biology of Microbial Growth" (pp. 202-222).

SUPPLEMENTAL READING: Morris et al. (2008) Towards a biomechanical understanding of whole bacterial cells. Annu Rev Biochem 77: 583-613 PMID: 18355161.

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WEEK 04 : 2025.03.12 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.03.12 (16:15-18:00) MINIPROJECTS (CE 2)

“WORK ON MINIPROJECTS”

SPECIAL EVENT: EPFL SUSTAINABLE INNOVATION CHALLENGE
2025.03.13 & 2025.03.14
ROLEX LEARNING CENTER
URL: https://epfl-sic.ch/
SEE LINK TO PRESENTATION BELOW
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WEEK 05 : 2025.03.19 (14:15-16:00) 1st EXAM (CE 1.106)

                      2025.03.19 (16:15-18:00) LECTURES (CE 2)

"TRANSPORT ACROSS THE BACTERIAL CELL ENVELOPE"

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 4 "Molecular Information Flow and Protein Processing" (pp. 102-136).

SUPPLEMENTAL READING:

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WEEK 06 : 2025.03.26 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.03.26 (16:15-18:00) LECTURES (CE 2)

"BIOMECHANICS OF MICROBIAL SURFACE APPENDAGES"

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 2 "Microbial Cell Structure and Function" Section III "Cell Surface Structures and Inclusions" (pp. 48-56) and Chapter 25 "Microbial Infection and Pathogenesis" Section I "Human-Microbial Interaction" (pp. 758-764).

SUPPLEMENTAL READING:

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WEEK 07 : 2025.04.02 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.04.02 (16:15-18:00) LECTURES (CE 2)

“BACTERIAL MOTILITY AND CHEMOTAXIS”

BACKGROUND READING: Brock Biology of Microorganisms [15th edition], Chapter 2 "Microbial Cell Structure and Function" Section IV "Cell Locomotion" (pp. 56-64).

SUPPLEMENTAL READING: Jarrell et al. (2008) The surprisingly diverse ways that prokaryotes move. Nat Rev Microbiol 6(6): 466-476 PMID: 18461074. Lauga et al. (2009) The hydrodynamics of swimming microorganisms. Rep Prog Phys 72(9): 096601 doi:10.1088/0034-4885/72/9/096601.

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WEEK 08 : 2025.04.09 (14:15-16:00) EXERCISES (CE 1.106)

                      2025.04.09 (16:15-18:00) MINIPROJECTS (CE 2)

“WORK ON MINIPROJECTS”

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WEEK 09 : 2025.04.16 (14:15-16:00) 2nd EXAM (CE 1.106)

                      2025.04.16 (16:15-18:00) LECTURES (CE 2)

“GLOBAL CARBON CYCLE AND METABOLIC SYMBIOSIS”

BACKGROUND READING:

Brock Biology of Microorganisms [15th edition], Chapter 3 "Microbial Metabolism" (pp. 73-101).

Brock Biology of Microorganisms [15th edition], Chapter 14 "Metabolic Diversity of Microorganisms" (pp. 392-450).

Brock Biology of Microorganisms [15th edition], Chapter 21 "Nutrient Cycles" (pp. 651-671).

Brock Biology of Microorganisms [15th edition], Chapter 23 "Microbial Symbioses with Microbes, Plants, and Animals" (pp. 696-728).

SUPPLEMENTAL READING:

Martin et al. (2014) Energy at life's origin: analysis of the bioenergetics of primitive organisms suggests that life began at hydrothermal vents. Science 344: 1092-1093 PMID: 24904143.

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“NO CLASSES THIS WEEK - SPRING SEMESTER BREAK”

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WEEK 10 : 2025.04.30 (14:15-16:00) EXERCISES (CE 1.106)

                   2025.04.30 (16:15-18:00) LECTURES (CE 2)

“GLOBAL NITROGEN CYCLE AND METABOLIC SYMBIOSIS”

BACKGROUND READING:

Brock Biology of Microorganisms [15th edition], Chapter 3 "Microbial Metabolism" (pp. 73-101).

Brock Biology of Microorganisms [15th edition], Chapter 14 "Metabolic Diversity of Microorganisms" (pp. 392-450).

Brock Biology of Microorganisms [15th edition], Chapter 21 "Nutrient Cycles" (pp. 651-671).

Brock Biology of Microorganisms [15th edition], Chapter 23 "Microbial Symbioses with Microbes, Plants, and Animals" (pp. 696-728).

SUPPLEMENTAL READING:

Fiore et al. (2010) Nitrogen fixation and nitrogen transformations in marine symbioses. Trends in Microbiology 18(10): 455-463 PMID: 20674366.

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WEEK 11 : 2025.05.07 (14:15-16:00) EXERCISES (CE 1.106)

                     2025.05.07 (16:15-18:00) LECTURES (CE 2)

“GENETIC NETWORKS IN BACTERIAL SPORULATION”

BACKGROUND READING:

Brock Biology of Microorganisms [15th edition], Chapter 7 Section 2 "Regulation of development in model Bacteria" (pp. 212-217).

Brock Biology of Microorganisms [15th edition], Chapter 4 Section 3 "RNA synthesis: transcription" (pp. 115-120).

Brock Biology of Microorganisms [15th edition], Chapter 6 Section 1 "DNA binding proteins and transcriptional regulation" (pp. 174-182).
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WEEK 12 : 2025.05.14 (14:15-16:00) EXERCISES (CE 1.106)

                     2025.05.14 (16:15-18:00) MINIPROJECTS (CE 2)

“WORK ON MINIPROJECTS”

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WEEK 13 : 2025.05.21 (14:15-16:00) 3rd EXAM (CE 1.106)

                     2025.05.21 (16:15-18:00) MINIPROJECTS (CE 2)

“WORK ON MINIPROJECTS”

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WEEK 14 : 2025.05.28 (14:15-16:00) PRESENTATIONS (CE 1.106)

                     2025.05.28 (16:15-18:00) POSTER SESSION (CE 2)

“MINIPROJECT PRESENTATIONS AND POSTER SESSION”

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“NO CLASSES THIS WEEK - SPRING SEMESTER BREAK”

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