Biomaterials (pour MX)
MSE-471
Welcome to Biomaterials for MX!
Developing materials for use in medicine is a challenging interdisciplinary process and requires an understanding of material bulk and surface properties, the various biological responses to the materials, the clinical context of their use, manufacturing
processes, cost, sterilization, packaging and regulatory issues. This course is designed to introduce students to the various classes of biomaterials in use and their application in selected subspecialties of medicine.
We will cover the different types of biomaterials, their structure, function, processing, applications, and focus on their interaction with the living world. Guest lectures will cover specialised topics of immune system, stem cells and neuroprostetics. The course will end with examples of the biomaterial translation from lab to industry and regulatory aspects.
Evaluation of the material via written exam at the end of the course + Lab paper to be handed in latest at noon on Wednesday 18 December on Moodle (See submission portal in last week)
Presence at the practicum will be tracked on a sign-off sheet and are mandatory.
For questions, contact Professor Bastings: maartje.bastings@epfl.ch
Contact the Programmable Biomaterials Laboratory for Master projects, internships and thesis research! http://pbl.epfl.ch
LECTURES WILL BE ON SITE and NOT recorded
Time : Wednesday 9-11.00 (course)
Thursday 8.15-10.00 (Lab).
Room : Lectures: CHB 331
Lab: MED2 2423 (classroom) / MED3 1519 (practical)
Main references :
Biomaterials Science (3rd edition) - An introduction to Materials in Medicine - Buddy D. Ratner - 2013. E-book : http://library.epfl.ch/nebis/?record=009920460 .
Human Anatomy & Physiology - Elaine N. Marieb and Katja N Hoehn.
Biological performance of Materials - Fundamentals of Biocompatibiliy - Jonathan Black.
DLL TP BLOCK 1 (TP 2-3) - Hydrogels
- TP1 classroom slides 2024 (File)
- TP2 calculation slides2024 (File)
- TP MSE471 2024 1 Gelation experiments (File)
- Lab notebook DLL2024 (File)
- Tips for experimental design (2024) (File)
DLL TP BLOCK 2 (TP 4-5) - Cell adhesion
- TP4-5 Demo for Basic cell work (URL)
- TP4-5 Microscope protocol (File)
- TP4-5 Basics of cell work (File)
DLL TP BLOCK 3 (TP 6-8) - Cell culture and Gel Prep
- 1. Cytotoxicity protocol (File)
- 2.1 Gel preparation protocol (File)
- 2.2 Gel Prep demo and Rheology demo2 (URL)
- 3.1 Rheology demo1 (URL)
- 3.2 Rheological data (File)
- 3.3. Class slides (File)
- 2h cytotoxicity (Folder)
- 12h cytotoxicity (Folder)
DLL TP BLOCK 4 (TP 9-11) - Cell staining and Nanolive
- 4.1 Image processing FIJI demo (URL)
- 4.1 Cell staining and image processing protocol (File)
- 4.2 Introduction to NanoLive on Youtube. EP1 (5 min) (URL)
- 4.2 Introduction to NanoLive on Youtube. EP2 (7 min) (URL)
- 4.2 Introduction to Nanolive on Youtube. EP3 (6 min) (URL)
- 4.2 Nanolive imaging demo in LAB (URL)
- 4.2 Presentation on holotomographic imaging_updated (File)
- Demo cell images (2022) (Folder)
- Cell staining images (Folder)
DLL TP BLOCK 5 (TP 12-13) - Tissue engineering
- Cell seeding and Gel Staining demo (URL)
- Gel-based 3D cell culture protocol (File)
- Gel-based 3D cell culture images (Folder)
- Pixel sizes and scale bar addition (File)
September 11th: Intro
Lecture 1: Introduction to Biomaterials
- Biomaterials Science book (URL)
- Chapter Intro to Biomaterials (File)
- 2024 Biomaterials Course 1 (File)
- Links to the youtube videos to watch again (Page)
- TP1 2024 (File)
September 18: Natural Biomaterials
September 25: Metals and manmade biomaterials
October 2: Polymers, Particles and Surfaces (2024)
- 2024 MSE 471 Week 4 (File)
- Background reading surfaces (Folder)
- Background reading Polymers and Particles (Folder)
October 9: Materials for drug delivery and targeting
October 16: Engineering Cell Adhesion
- 2024 MSE 471 course 6 adhesion (File)
- Cell Adhesion Background literature (Folder)
- Literature (Folder)
- Video spinal repair (URL)
October 30: Immune Engineering
November 6: Tissue Engineering
November 13: Characterization and Performance
November 20: Sensors and Diagnostic Devices
November 27: Translation, Spin-Offs, Patents
December 4: Regulatory Aspects and Trials
This lecture was given by Gautam Maitra from SV, Innovate4Life
As I jumped in to get the course back on the road the course material for this week (and exam) is what we discussed in class on the blackboard. I will not upload his slides, as you can find information on SV innovate4life and himself easily on EPFL website.
Main points are thus the steps involved from lab discovery to market, the GMP and variants on it, and the role (and power) of the regulatory offices.