accession	protein_group_id	protein_group_accessions	gene_names	description	number_peptides	number_unique_peptides	number_psm	biological_process	cellular_component	molecular_function	gene_symbol	wikipathways	kegg_pathways	reactome_pathways	diseased_healthy_logFC	diseased_healthy_pval	diseased_healthy_fdr	diseased_healthy_candidate	healthy_1	healthy_2	healthy_3	healthy_4	healthy_5	diseased_1	diseased_2	diseased_3	diseased_4	diseased_5
P04114	719	P04114;A8MUN2;A0A669KB70	APOB	Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=2	288	285	8361	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;membrane;organelle lumen	protein binding;transporter activity	APOB	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Statin Pathway	Fat digestion and absorption; Vitamin digestion and absorption	Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); LDL remodeling; Scavenging by Class H Receptors; VLDL clearance; Retinoid metabolism and transport; Chylomicron remodeling; Scavenging by Class A Receptors; LDL clearance; Platelet sensitization by LDL; Signaling by GPCR; Scavenging by Class B Receptors; Scavenging by Class F Receptors; VLDL assembly; Chylomicron assembly; Regulation of TLR by endogenous ligand; Cell surface interactions at the vascular wall; Chylomicron clearance	0.855411763	0.010924784	0.021673362	FDR <= 0.05	30.36643066	30.38225123	30.22268078	30.34198342	30.12577037	30.96779062	30.13441027	31.61355124	31.10764805	31.89277509
P01024	241	P01024;M0QYC8;M0QXZ3;M0R0Q9	C3	Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2	138	120	7764	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;enzyme regulator activity;protein binding	C3	Allograft Rejection; TYROBP Causal Network; Complement Activation; Complement and Coagulation Cascades	Staphylococcus aureus infection; Complement and coagulation cascades; Tuberculosis; Viral carcinogenesis; Herpes simplex infection; Phagosome; Leishmaniasis; Legionellosis; Systemic lupus erythematosus; Pertussis; Chagas disease (American trypanosomiasis)	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Alternative complement activation; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; G alpha (i) signalling events	2.413441261	1.12e-07	3.04e-06	FDR <= 0.01	30.17526971	30.18404395	30.03334674	30.1303434	29.99142271	32.58146015	33.25517849	32.10612842	32.3133157	32.32555005
P08603	575	P08603;P08603-2	CFH	Complement factor H OS=Homo sapiens OX=9606 GN=CFH PE=1 SV=4	87	46	7147	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	CFH	Complement and Coagulation Cascades	Complement and coagulation cascades; Staphylococcus aureus infection	Regulation of Complement cascade	2.001120819	9.31e-08	3.04e-06	FDR <= 0.01	29.73570792	29.76280612	29.62249767	29.71649813	29.56241201	31.70866969	32.23292283	31.40506347	31.39862169	31.66024827
P02751	535	P02751;P02751-7;P02751-3;P02751-8;P02751-14;P02751-1;P02751-9;P02751-17;P02751-11;P02751-10;P02751-6;P02751-13;P02751-5;P02751-12;P02751-4;H0Y7Z1;P02751-16;P02751-2;H0Y4K8	FN1	Fibronectin OS=Homo sapiens OX=9606 GN=FN1 PE=1 SV=5	76	76	4266								2.414967535	1.97e-08	2.02e-06	FDR <= 0.01	28.62440993	28.63633296	28.42493748	28.55741038	28.39340196	31.01170402	31.30962238	31.11981695	30.38397594	30.88621111
P0C0L5	666	P0C0L5;A0A0G2JL54;F5GXS0;A0A3B3ISA6	C4B	Complement C4-B OS=Homo sapiens OX=9606 GN=C4B PE=1 SV=2	88	1	4816	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;enzyme regulator activity;protein binding	C4B; C4B_2; LOC100293534	Allograft Rejection; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	Pertussis; Complement and coagulation cascades; Staphylococcus aureus infection; Systemic lupus erythematosus	Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5	1.218938382	7.2e-07	8.04e-06	FDR <= 0.01	30.03043207	29.97669326	29.87856434	29.97298329	29.80242497	31.08876095	31.17080269	30.98495956	31.0157851	31.49548155
P0C0L4	582	P0C0L4;P0C0L4-2	C4A	Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2	87	1	4780	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane;organelle lumen	catalytic activity;enzyme regulator activity;protein binding	C4A; C4B	Allograft Rejection; Complement Activation; Complement and Coagulation Cascades; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	Staphylococcus aureus infection; Pertussis; Systemic lupus erythematosus; Complement and coagulation cascades	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5	0.741569927	2.19e-05	0.000106506	FDR <= 0.01	20.0428851	19.979648	19.89997567	20.09782478	20.08524013	20.85091548	20.80042544	20.71137668	20.53248578	20.91821993
A0A0G2JPR0	415	A0A0G2JPR0;A0A140TA49;A0A140TA32	C4A	C4a anaphylatoxin OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=1	87	0	4826	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;protein binding	LOC100294156				0.96357057	0.006586885	0.013778689	FDR <= 0.05	23.1164469	23.0856216	23.00793246	23.15654309	22.95813976	24.46955273	24.36137183	24.67562691	22.96843198	23.66755322
P01023	391	P01023;F8W7L3;H0YFH1	A2M	Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3	70	58	3747	cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;organelle lumen	enzyme regulator activity;protein binding	A2M	Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Degradation of the extracellular matrix; Rho GTPase cycle; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation	-0.125322752	0.521136283	0.58485185	FDR > 0.05	29.78660594	29.84755973	29.64648566	29.78616734	29.60800976	30.15658891	29.87063422	29.05168217	29.60144577	29.3678636
A0A0C4DGB6	269	A0A0C4DGB6	ALB	Albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=1	73	1	3989	cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen	antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding	ALB	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism			0.515296543	0.013511037	0.026047925	FDR <= 0.05	15.71287606	15.38983854	15.30777849	15.71316658	15.60604617	16.3339555	16.26563821	16.09566845	15.45234552	16.15858089
P01031	52	P01031	C5	Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4	73	66	2258	cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;protein binding	C5	Allograft Rejection; Spinal Cord Injury; Oxidative Damage; Complement Activation	Complement and coagulation cascades; Staphylococcus aureus infection; Prion diseases; Systemic lupus erythematosus; Pertussis; Herpes simplex infection	Terminal pathway of complement; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; G alpha (i) signalling events	1.799381003	1.63e-08	2e-06	FDR <= 0.01	28.47197482	28.48362954	28.3483797	28.48245411	28.26451488	30.44591993	30.2654536	30.06937377	29.9344883	30.33262246
P04275	517	P04275;P04275-2	VWF	von Willebrand factor OS=Homo sapiens OX=9606 GN=VWF PE=1 SV=4	68	68	649	cell organization and biogenesis;coagulation;metabolic process;response to stimulus;transport	endoplasmic reticulum;extracellular;organelle lumen	protein binding	VWF	Blood Clotting Cascade; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Complement and Coagulation Cascades	ECM-receptor interaction; PI3K-Akt signaling pathway; Platelet activation; Focal adhesion; Complement and coagulation cascades	Integrin cell surface interactions; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Intrinsic Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet Adhesion to exposed collagen; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling	-0.120392255	0.354652889	0.427669661	FDR > 0.05	25.49552	25.55591538	25.47021009	25.51169628	25.40807281	25.18337616	25.67228955	25.46392599	25.07023953	25.44962205
Q9Y6R7	619	Q9Y6R7;A0A087WXI2;A0A087WUZ2	FCGBP	IgGFc-binding protein OS=Homo sapiens OX=9606 GN=FCGBP PE=1 SV=3	59	59	635		extracellular	protein binding	FCGBP				0.322367673	0.160368249	0.209398032	FDR > 0.05	25.42603642	25.46432938	25.35789307	25.42529542	25.28902052	26.36278841	25.46032225	25.99549971	25.03657342	25.71922939
B4E1Z4	638	B4E1Z4;P00751;A0A0G2JH38;P00751-2;H7C5H1;C9JRT3;H7C526		C3/C5 convertase OS=Homo sapiens OX=9606 PE=1 SV=1	48	28	969	metabolic process		catalytic activity					-2.371695818	1.06e-06	1.07e-05	FDR <= 0.01	29.22257963	29.23184809	29.01258329	29.15868793	28.98671316	26.59038942	26.96927978	26.24392538	27.63149648	26.31884195
P02787	530	P02787;H7C5E8;F8WCI6;F8WEK9;C9JB55	TF	Serotransferrin OS=Homo sapiens OX=9606 GN=TF PE=1 SV=3	50	43	1237	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endosome;extracellular;membrane;organelle lumen	enzyme regulator activity;metal ion binding;protein binding;transporter activity	TF	Iron metabolism in placenta; Differentiation Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	HIF-1 signaling pathway; Mineral absorption	Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling	0.832993948	3.7e-05	0.000163822	FDR <= 0.01	27.92138685	27.96573478	27.83084598	27.9257951	27.69939714	28.9676571	28.67404617	28.60462267	28.40895242	28.85285124
A0A0D9SG88	297	A0A0D9SG88;Q5TFM2	CFH	Complement factor H OS=Homo sapiens OX=9606 GN=CFH PE=1 SV=1	36	3	2613	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	CFH	Complement and Coagulation Cascades			2.015022817	1.02e-07	3.04e-06	FDR <= 0.01	21.99564341	22.26941015	22.11343262	22.16153202	22.26734311	24.27413317	24.61984523	23.97971422	23.72603095	24.28275184
P00747	458	P00747	PLG	Plasminogen OS=Homo sapiens OX=9606 GN=PLG PE=1 SV=2	42	32	1105	cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;metabolic process;regulation of biological process;transport	cell surface;extracellular;membrane;organelle lumen	catalytic activity;protein binding	PLG	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades; Influenza A; Staphylococcus aureus infection; Neuroactive ligand-receptor interaction	Platelet degranulation ; Dissolution of Fibrin Clot; Activation of Matrix Metalloproteinases; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF	-1.269207668	0.000396267	0.001224643	FDR <= 0.01	28.71032219	28.69958294	28.58603012	28.65553268	28.46745625	26.67193747	27.00310956	27.57788765	28.24973792	27.27021325
P04003	122	P04003;A6PVY5;F2Z2V7	C4BPA	C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2	33	33	2059	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding;RNA binding	C4BPA		Complement and coagulation cascades; Pertussis	Regulation of Complement cascade	1.455715636	2.14e-06	1.73e-05	FDR <= 0.01	27.99708659	28.05665353	28.01169511	27.9366755	27.84472589	29.38374878	29.15031965	29.5206138	29.11369356	29.95703901
P15924	353	P15924;P15924-3;P15924-2	DSP	Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3	76	76	447	cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;membrane;nucleus	catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity	DSP	Arrhythmogenic Right Ventricular Cardiomyopathy; Lung fibrosis	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation	0.481795987	0.125053676	0.168288864	FDR > 0.05	24.52826923	23.56551059	23.39329338	24.08986747	23.52124355	24.03590389	24.96161387	24.52188706	24.44027395	23.54748538
P01009	325	P01009;A0A024R6I7;P01009-2;A0A0G2JRN3;P01009-3;G3V544;A0A0B4J278;G3V5R8;G3V387	SERPINA1	Alpha-1-antitrypsin OS=Homo sapiens OX=9606 GN=SERPINA1 PE=1 SV=3	34	23	1788	cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen	enzyme regulator activity;protein binding	SERPINA1	NRF2 pathway; Lung fibrosis; Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport	-1.97026962	4.93e-07	6.46e-06	FDR <= 0.01	30.22799373	30.22388797	30.09150705	30.09330674	30.0280051	28.16137441	27.92885936	27.76038229	28.85152928	28.11120715
P01871	173	P01871;P01871-2	IGHM	Immunoglobulin heavy constant mu OS=Homo sapiens OX=9606 GN=IGHM PE=1 SV=4	32	32	4275	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;membrane	DNA binding;protein binding	IGHM			CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cell surface interactions at the vascular wall	1.669008061	0.000203601	0.000700404	FDR <= 0.01	29.75202987	29.75503346	29.68687983	29.73470122	29.61434873	32.44267514	31.86571976	31.05313372	30.71227797	30.81422683
P00450	238	P00450	CP	Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1	33	2	764	cellular homeostasis;metabolic process;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	CP		Porphyrin and chlorophyll metabolism	Metal ion SLC transporters; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Iron uptake and transport; Defective CP causes aceruloplasminemia (ACERULOP)	-0.157353091	0.228336532	0.287760179	FDR > 0.05	25.95165503	26.01331913	25.82435465	25.76895197	25.78759893	25.97444955	25.54143963	25.88978423	25.47167891	25.68176193
Q07954	528	Q07954;Q6PJ72;Q7Z7K9;Q07954-2;H0YJI8	LRP1	Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2	56	56	353	cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endosome;membrane;nucleus	metal ion binding;protein binding;receptor activity;RNA binding;transporter activity	LRP1	Alzheimers Disease; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; Statin Pathway	Malaria; Alzheimer's disease	Signaling by GPCR; Scavenging of heme from plasma; Retinoid metabolism and transport	0.97651359	5.46e-07	6.85e-06	FDR <= 0.01	23.05633286	23.07343372	23.04738663	23.08278922	23.03057245	24.20897986	23.96768279	24.0380092	23.89644258	24.0619684
P01857	63	P01857;A0A0A0MS08;A0A0A0MS07	IGHG1	Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1	26	13	3999	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;metal ion binding;protein binding	IGHG1			Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis	-0.86174112	0.002297879	0.005675485	FDR <= 0.01	31.45292173	31.43800389	31.39923009	31.39944233	31.23166463	30.64667351	29.69157371	30.97882324	30.42769322	30.86779339
P06396	383	P06396	GSN	Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1	32	1	778	cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	metal ion binding;protein binding	GSN	Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer	Fc gamma R-mediated phagocytosis; Viral carcinogenesis; Regulation of actin cytoskeleton	Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins; Amyloid fiber formation	-1.618110829	3.01e-06	2.26e-05	FDR <= 0.01	21.13571824	21.05394045	20.90439436	20.97881304	20.86166818	19.35902855	19.90975678	19.06077469	19.60897857	18.90544154
P10643	502	P10643	C7	Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2	35	35	459	cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	C7	Allograft Rejection; Complement Activation; Complement and Coagulation Cascades	Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades	Terminal pathway of complement; Regulation of Complement cascade	0.048621087	0.795403253	0.827703892	FDR > 0.05	26.37887037	26.47131088	26.36618844	26.38947032	26.25564583	26.07764639	26.16848369	26.76866677	26.11908858	26.97070584
P06396-2	250	P06396-2;Q5T0I0	GSN	Isoform 2 of Gelsolin OS=Homo sapiens OX=9606 GN=GSN	33	2	763	cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	metal ion binding;protein binding	GSN	Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer			-1.883857442	2.49e-05	0.000115561	FDR <= 0.01	27.23644147	27.23834601	27.10793907	27.17877324	26.95774784	24.94993527	26.16177916	24.74449662	25.71242636	24.73132301
P03952	549	H0YAC1;P03952;E9PBC5;C9J075;C9JCT1	KLKB1	Plasma kallikrein OS=Homo sapiens OX=9606 GN=KLKB1 PE=1 SV=1	34	34	625	cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	KLKB1	Complement and Coagulation Cascades	Complement and coagulation cascades	Activation of Matrix Metalloproteinases; Intrinsic Pathway of Fibrin Clot Formation	-0.57728023	0.058058107	0.090623695	FDR > 0.05	26.38983744	26.42159454	26.31543733	26.40887428	26.24621501	25.54873773	25.7507942	25.46456999	26.91815344	25.21330209
E9PFZ2	91	E9PFZ2	CP	Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1	32	1	637	cellular homeostasis;metabolic process;transport		catalytic activity;metal ion binding					-2.810578336	5.88e-06	3.73e-05	FDR <= 0.01	21.67241364	21.74571982	21.61544035	21.52541535	21.57393065	18.82303598	18.83473686	17.79106705	20.12269033	18.50849791
B7ZKJ8	663	B7ZKJ8;Q14624	ITIH4	ITIH4 protein OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=1	30	3	1238	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	enzyme regulator activity;protein binding	ITIH4				-0.563036643	0.000314478	0.001017916	FDR <= 0.01	27.16438134	27.27681343	27.10917512	27.16629031	27.05155142	26.68466152	26.38397575	26.82115663	26.52246272	26.54077179
B4DPQ0	49	B4DPQ0;A0A3B3ISR2;P00736;F5H2D0;A0A3B3ITU4;F5H1V0;F5H6Y3;F5H3N3	C1R	Complement subcomponent C1r OS=Homo sapiens OX=9606 GN=C1R PE=1 SV=1	29	26	884	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	C1R	Oxidative Damage; Complement Activation; Complement and Coagulation Cascades			1.524222281	1.12e-06	1.09e-05	FDR <= 0.01	26.50850988	26.61219527	26.50874963	26.44843037	26.38905799	27.93410738	27.61798899	28.18338307	27.86559035	28.48698475
P00738	207	P00738;J3QLC9;P00738-2;H3BS21;J3KRH2;J3KSV1;H3BMJ7;J3QQI8	HP	Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1	28	2	1210	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	antioxidant activity;catalytic activity;protein binding	HP			Neutrophil degranulation; Scavenging of heme from plasma	0.763187365	0.000274231	0.000897084	FDR <= 0.01	28.10749172	27.9905969	27.83237927	27.97848124	27.8132157	29.05426475	28.76013977	28.60523394	28.29421999	28.8242432
P02679	522	P02679;P02679-2;C9JC84;C9JEU5	FGG	Fibrinogen gamma chain OS=Homo sapiens OX=9606 GN=FGG PE=1 SV=3	28	17	697	cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;structural molecule activity	FGG	Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway	Staphylococcus aureus infection; Platelet activation; Complement and coagulation cascades	Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling	1.248363622	0.108963192	0.149915801	FDR > 0.05	25.58747109	25.63893253	25.50198942	25.38418586	25.43265471	25.09537881	29.72761643	26.51020987	26.96283714	25.49100947
P00734	463	P00734;E9PIT3;C9JV37	F2	Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2	27	27	522	cellular component movement;cellular homeostasis;coagulation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	F2	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; IL1 and megakaryocytes in obesity; Regulation of Actin Cytoskeleton; Complement and Coagulation Cascades	Complement and coagulation cascades; Regulation of actin cytoskeleton; Neuroactive ligand-receptor interaction	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors; Thrombin signalling through proteinase activated receptors (PARs); Platelet Aggregation (Plug Formation); Regulation of Complement cascade; Common Pathway of Fibrin Clot Formation; Gastrin-CREB signalling pathway via PKC and MAPK; Cell surface interactions at the vascular wall	-1.996983217	2.7e-06	2.08e-05	FDR <= 0.01	27.27562473	27.27479363	27.10589963	27.23632122	27.02006203	25.05267139	24.91374862	24.94539443	26.1111953	24.9047754
H0Y300	540	H0Y300	HP	Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=4	27	1	1183	metabolic process	extracellular	catalytic activity;protein binding					0.639910408	9.55e-05	0.00035586	FDR <= 0.01	15.36998915	15.24263565	15.25953268	15.00705055	15.23487156	15.95778826	15.82547819	15.95461891	15.66854807	15.90719818
P01876	141	P01876;A0A286YEY1	IGHA1	Immunoglobulin heavy constant alpha 1 OS=Homo sapiens OX=9606 GN=IGHA1 PE=1 SV=2	20	7	1841	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	protein binding	IGHA1	Inflammatory Response Pathway		Scavenging of heme from plasma; Cell surface interactions at the vascular wall	-0.035301249	0.890374084	0.905091011	FDR > 0.05	29.77318836	29.72729966	29.60935197	29.68675601	29.45871438	30.43960842	29.44649807	30.00068409	29.22808085	28.96393271
P19823	29	P19823;Q5T985;Q5T987	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2	28	22	949	metabolic process;regulation of biological process	extracellular;organelle lumen	enzyme regulator activity	ITIH2			Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-1.455019005	0.00023554	0.000793515	FDR <= 0.01	28.06139945	28.08292904	27.98358182	28.11234706	27.8702671	26.06043277	27.58622392	26.12530252	26.85443282	26.2090374
P09871	187	P09871;A0A087X232;F8WCZ6;H0Y5D1;F5H7T4;B5MCV4	C1S	Complement C1s subcomponent OS=Homo sapiens OX=9606 GN=C1S PE=1 SV=1	27	26	1259	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	C1S	Oxidative Damage; Complement Activation; Complement and Coagulation Cascades	Complement and coagulation cascades; Systemic lupus erythematosus; Pertussis; Staphylococcus aureus infection	Regulation of Complement cascade; Classical antibody-mediated complement activation	1.466359009	2.01e-06	1.67e-05	FDR <= 0.01	26.85854074	26.90099469	26.83159061	26.98532447	26.73248689	28.46169388	27.97883225	28.53813432	27.96012796	28.70194405
P13671	60	P13671	C6	Complement component C6 OS=Homo sapiens OX=9606 GN=C6 PE=1 SV=3	37	37	660	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	C6	Allograft Rejection; Complement Activation; Complement and Coagulation Cascades	Complement and coagulation cascades; Systemic lupus erythematosus; Prion diseases	Terminal pathway of complement; Regulation of Complement cascade	-0.498478901	0.035448339	0.058973248	FDR > 0.05	26.8852074	26.87190076	26.75711112	26.85561196	26.60137861	25.82572219	27.01118882	26.39650507	25.88878303	26.35661624
P12259	329	P12259;A0A0A0MRJ7	F5	Coagulation factor V OS=Homo sapiens OX=9606 GN=F5 PE=1 SV=4	43	43	340	cell organization and biogenesis;coagulation;metabolic process;response to stimulus;transport	endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen	metal ion binding;protein binding	F5	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport	-1.187452929	2.26e-07	4.33e-06	FDR <= 0.01	24.62711228	24.63371619	24.52967225	24.61196037	24.49819976	23.22322865	23.32875943	23.41661714	23.63622202	23.35856897
P19827	599	P19827;P19827-2;P19827-3;F8WAS2	ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3	28	21	725	metabolic process;regulation of biological process	extracellular	enzyme regulator activity;metal ion binding	ITIH1				-1.392629131	0.000699384	0.001982124	FDR <= 0.01	26.97062458	27.03256751	26.85464079	26.88401685	26.86670759	25.14074504	26.70228145	24.9605123	25.77408033	25.06779255
P05160	484	P05160;A0A3B3IS66	F13B	Coagulation factor XIII B chain OS=Homo sapiens OX=9606 GN=F13B PE=1 SV=3	28	28	339	coagulation	extracellular		F13B	Blood Clotting Cascade; Steroid Biosynthesis; Complement and Coagulation Cascades	Complement and coagulation cascades	Common Pathway of Fibrin Clot Formation	-0.393697817	0.325090124	0.395901834	FDR > 0.05	25.04589416	25.12955354	25.0513352	25.08606816	25.00248236	23.89450102	26.29878494	24.59932667	24.51988546	24.03434626
P04264	233	P04264	KRT1	Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6	41	31	534	cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoskeleton;cytosol;extracellular;membrane;nucleus	catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity	KRT1	Corticotropin-releasing hormone signaling pathway		Formation of the cornified envelope; Neutrophil degranulation	0.400970415	0.34732197	0.419652281	FDR > 0.05	27.83336074	27.1009886	26.54302599	27.37709589	26.73074048	26.72392426	28.35780332	28.11261225	28.00089599	26.39482795
P20742	605	P20742;P20742-2;F5GXY0	PZP	Pregnancy zone protein OS=Homo sapiens OX=9606 GN=PZP PE=1 SV=4	34	27	502	regulation of biological process	extracellular	enzyme regulator activity	PZP				0.164511323	0.601381766	0.659268781	FDR > 0.05	23.69225012	23.70562019	23.5874411	23.64694699	23.54957214	25.07043693	23.62016092	23.84721546	23.24730233	23.21927151
P35527	691	P35527;K7EQQ3	KRT9	Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3	25	24	393	cell death;cell organization and biogenesis	cytosol;membrane;nucleus	structural molecule activity	KRT9			Formation of the cornified envelope	0.40871013	0.347186362	0.419652281	FDR > 0.05	27.33423833	26.15968324	26.06387272	26.79900886	26.43867674	26.31220219	27.96037435	27.67339808	27.10949489	25.78356103
A0A4W9A917	340	P01860;A0A4W9A917;A0A286YES1	IGHG3	Immunoglobulin heavy constant gamma 3 (Fragment) OS=Homo sapiens OX=9606 GN=IGHG3 PE=1 SV=1	20	8	2905								-0.293039256	0.231777868	0.291499773	FDR > 0.05	27.92880901	27.9334957	27.87732508	27.85708582	27.79087989	27.81215723	27.21006048	28.41536564	26.9988596	27.48595628
P01859	196	P01859;A0A286YEY4	IGHG2	Immunoglobulin heavy constant gamma 2 OS=Homo sapiens OX=9606 GN=IGHG2 PE=1 SV=2	18	9	2325	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	IGHG2			FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Regulation of Complement cascade; Role of phospholipids in phagocytosis; Classical antibody-mediated complement activation	-0.897109672	0.008402254	0.017110551	FDR <= 0.05	28.88988364	28.90495606	28.88960565	28.83673371	28.80557322	28.30497379	27.37262037	29.01454152	27.60121003	27.54785819
P00739	198	P00739-2;P00739;A0A0A0MRD9;J3KTC3	HPR	Haptoglobin-related protein OS=Homo sapiens OX=9606 GN=HPR PE=2 SV=2	23	7	1016	metabolic process;transport	extracellular	catalytic activity;protein binding	HPR		African trypanosomiasis	Scavenging of heme from plasma	-0.112142171	0.616506997	0.669157467	FDR > 0.05	24.96536529	25.13177455	25.05151692	24.93466084	25.02093262	25.7118457	24.97035197	24.8794813	24.66946231	24.31239808
P01012	560	P01012	SERPINB14	Ovalbumin OS=Gallus gallus OX=9031 GN=SERPINB14 PE=1 SV=2	17	17	883	regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;extracellular;organelle lumen;vacuole	enzyme regulator activity;metal ion binding;protein binding	OVAL; SERPINB14			Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	2.02569599	0.030928441	0.052399425	FDR > 0.05	23.79699146	28.5620023	28.39993294	28.35907608	28.35363396	29.84595511	29.77916226	29.17328937	29.38127189	29.42043807
P07996	84	P07996;P07996-2;A8MZG1	THBS1	Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2	35	35	381	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endoplasmic reticulum;extracellular;organelle lumen	metal ion binding;protein binding	THBS1	Bladder Cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA targets in ECM and membrane receptors; Focal Adhesion; TGF-beta Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer	p53 signaling pathway; Phagosome; PI3K-Akt signaling pathway; Malaria; MicroRNAs in cancer; Bladder cancer; Proteoglycans in cancer; Focal adhesion; Rap1 signaling pathway; ECM-receptor interaction; TGF-beta signaling pathway	Platelet degranulation ; Integrin cell surface interactions; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Syndecan interactions	1.864251337	5.89e-05	0.000241455	FDR <= 0.01	23.06358234	23.13323051	22.99867978	23.09596377	23.02015063	25.10458325	25.99261214	24.23823864	24.28333972	25.01408996
A0A0G2JMB2	562	A0A0G2JMB2	IGHA2	Immunoglobulin heavy constant alpha 2 (Fragment) OS=Homo sapiens OX=9606 GN=IGHA2 PE=1 SV=1	17	1	1337	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding					0.730572455	0.009006986	0.018102276	FDR <= 0.05	16.71408346	16.78721877	16.56464596	16.82550464	16.89586375	18.3054823	17.34320481	17.58271852	16.8134956	17.39527762
P02671	281	P02671;P02671-2;A0A087WUA0	FGA	Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2	30	29	695	cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;extracellular;membrane;organelle lumen	metal ion binding;protein binding;structural molecule activity	FGA	Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway	Complement and coagulation cascades; Platelet activation	Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BRAF and RAF fusions; Amyloid fiber formation; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling	0.92597225	0.158240293	0.207059106	FDR > 0.05	25.50100553	25.48981806	25.36616718	25.42102961	25.358061	25.04381497	29.01516652	26.10521566	26.12887752	25.47286798
P02647	583	P02647;F8W696	APOA1	Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1	32	31	1515	cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen	enzyme regulator activity;protein binding;transporter activity	APOA1	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway	PPAR signaling pathway; African trypanosomiasis; Fat digestion and absorption; Vitamin digestion and absorption	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Amyloid fiber formation; Scavenging of heme from plasma; Retinoid metabolism and transport; Chylomicron remodeling; HDL assembly; ABC transporters in lipid homeostasis; PPARA activates gene expression; Scavenging by Class A Receptors; Signaling by GPCR; Platelet degranulation ; Scavenging by Class B Receptors; HDL remodeling; HDL clearance; Chylomicron assembly	-0.409873077	0.077601691	0.114448537	FDR > 0.05	30.07314712	30.09000033	29.99841356	30.05787849	29.92765751	29.90617618	28.94668406	30.24507224	29.38180064	29.6179985
P02675	354	P02675;D6REL8	FGB	Fibrinogen beta chain OS=Homo sapiens OX=9606 GN=FGB PE=1 SV=2	21	21	615	cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;extracellular;membrane;organelle lumen	protein binding;structural molecule activity	FGB	Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway; Complement and Coagulation Cascades	Complement and coagulation cascades; Platelet activation	Integrin cell surface interactions; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling	0.984564784	0.140280271	0.185931825	FDR > 0.05	25.0296635	25.03579937	24.90318474	25.02001293	24.87585714	24.66491787	28.60835479	25.8635682	25.78673086	24.86376988
P02533	154	P02533	KRT14	Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4	31	11	410	cell death;cell differentiation;cell organization and biogenesis;response to stimulus	cytoplasm;cytosol;nucleus	protein binding;structural molecule activity	KRT14	Corticotropin-releasing hormone signaling pathway		Formation of the cornified envelope; Type I hemidesmosome assembly	0.365600319	0.484571145	0.553534533	FDR > 0.05	26.3918379	24.1075885	24.08858137	24.93042969	24.22471719	24.53620554	25.67443853	25.37832279	25.98881221	23.99337718
A0A0G2JL69	362	A0A0G2JL69;P06681;P06681-3;H0Y3H6;P06681-2;A0A0G2JIE7;B4DQI1;E9PDZ0;A0A0G2JK28;Q8N6L6;H0Y868	C2	C3/C5 convertase OS=Homo sapiens OX=9606 GN=C2 PE=1 SV=1	24	5	361	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	C2	Allograft Rejection; Complement Activation; Complement and Coagulation Cascades			-0.283611247	0.038320627	0.063013864	FDR > 0.05	21.1266003	21.11664601	21.06456549	21.14798832	21.09528098	20.88736532	20.45570484	20.95427145	21.0524222	20.78326107
P08519	491	P08519;A0A087WWY0	LPA	Apolipoprotein(a) OS=Homo sapiens OX=9606 GN=LPA PE=1 SV=1	26	26	447	cell organization and biogenesis;metabolic process;regulation of biological process;transport	extracellular	catalytic activity;enzyme regulator activity;protein binding	LPA			LDL remodeling	0.600075629	0.083970768	0.122665136	FDR > 0.05	23.92321093	23.98486394	23.97842519	24.01557539	23.91572729	24.38928699	24.95317611	25.70559941	23.73361726	24.03650112
P01008	347	P01008	SERPINC1	Antithrombin-III OS=Homo sapiens OX=9606 GN=SERPINC1 PE=1 SV=1	23	19	834	coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	enzyme regulator activity;protein binding	SERPINC1	Complement and Coagulation Cascades	Complement and coagulation cascades	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation	-1.01646821	0.007612659	0.015710689	FDR <= 0.05	27.20524708	27.25412636	27.1458382	27.17313082	27.10475259	26.00498884	26.9335063	25.28504005	26.97389269	25.60332613
P07225	157	A0A0S2Z4L3;A0A3B3ISJ1;P07225;G5E9F8;A0A3B3IRK9;A0A3B3IUA6;C9K0R0	PROS1	Vitamin K-dependent protein S OS=Homo sapiens OX=9606 GN=PROS1 PE=1 SV=1	24	21	547	cellular component movement;coagulation;metabolic process;regulation of biological process;transport	cell surface;extracellular;membrane;organelle lumen	enzyme regulator activity;metal ion binding	PROS1	Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Regulation of Complement cascade; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	1.381008561	1.13e-06	1.09e-05	FDR <= 0.01	26.86851532	26.93117103	26.69667169	26.779712	26.72484042	28.06143092	27.95020677	28.2566995	28.00030936	28.6373067
P13645	225	P13645;Q7Z3Y7	KRT10	Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6	32	24	587	cell death;cell differentiation;metabolic process	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	structural molecule activity	KRT10		Staphylococcus aureus infection	Formation of the cornified envelope	0.438177569	0.314741692	0.384823341	FDR > 0.05	27.55942582	27.60461169	26.89492879	27.61234845	27.12159232	26.94436545	28.63540071	28.33928419	28.5586807	26.50606388
P06727	632	P06727	APOA4	Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4	31	29	529								-2.088943439	1.35e-08	2e-06	FDR <= 0.01	27.1312727	27.11858839	27.03021112	27.0110228	26.90671894	24.85932609	24.83843274	24.67933176	25.38941315	24.98659302
P23142	561	P23142	FBLN1	Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1 PE=1 SV=4	16	3	302	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;metal ion binding;protein binding;structural molecule activity	FBLN1			Molecules associated with elastic fibres	0.069438867	0.791338777	0.824870081	FDR > 0.05	24.84815925	24.84837826	24.73789476	24.74567582	24.6494062	24.77148567	23.98085239	25.65961523	24.6335908	25.13116453
A0A286YFJ8	7	P01861;A0A286YFJ8	IGHG4	Immunoglobulin heavy constant gamma 4 (Fragment) OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=1	14	8	1541								-1.082859922	0.005456581	0.011712205	FDR <= 0.05	28.23405117	27.92589742	27.96136007	28.03453574	27.88370337	27.21617996	25.75035469	27.85453205	26.88362449	26.92055696
P01011	614	P01011;G3V595;G3V3A0;P01011-2;A0A087WY93	SERPINA3	Alpha-1-antichymotrypsin OS=Homo sapiens OX=9606 GN=SERPINA3 PE=1 SV=2	20	20	372	defense response;regulation of biological process;response to stimulus;transport	extracellular;nucleus;organelle lumen	DNA binding;enzyme regulator activity;protein binding	SERPINA3	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism		Platelet degranulation ; Neutrophil degranulation	-2.388728315	2.97e-06	2.25e-05	FDR <= 0.01	28.22146952	28.23127231	28.07943932	28.19978534	28.04933402	25.57455585	25.53196794	25.19366871	26.89465897	25.64280747
P07358	409	P07358	C8B	Complement component C8 beta chain OS=Homo sapiens OX=9606 GN=C8B PE=1 SV=3	21	1	344	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	C8B	Allograft Rejection; Complement Activation	Prion diseases; Systemic lupus erythematosus; Complement and coagulation cascades; Amoebiasis	Terminal pathway of complement; Regulation of Complement cascade	-0.362552006	0.062980041	0.096590337	FDR > 0.05	25.6280921	25.69813232	25.54586013	25.6190441	25.44202839	24.72128293	25.15195336	25.79335905	25.33054871	25.12325296
F5GY80	506	F5GY80;F5H7G1	C8B	Complement component 8 subunit beta OS=Homo sapiens OX=9606 GN=C8B PE=1 SV=1	21	1	339	response to stimulus		protein binding					1.816576887	0.024755513	0.042765844	FDR <= 0.05	14.63655075	14.93035279	14.09470757	14.414409	14.59379539	17.03783062	16.49048831	18.64109904	13.87682244	15.70645952
P01877	294	P01877;A0A286YEY5	IGHA2	Immunoglobulin heavy constant alpha 2 OS=Homo sapiens OX=9606 GN=IGHA2 PE=1 SV=4	17	5	777	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	protein binding	IGHA2	Inflammatory Response Pathway		Scavenging of heme from plasma; Cell surface interactions at the vascular wall	-0.122632454	0.411787609	0.483300342	FDR > 0.05	24.56874677	24.6563881	24.54097617	24.65037166	24.59436602	24.983005	24.37109393	24.41831148	24.46160969	24.16366636
P98160	177	P98160;H7BYA5	HSPG2	Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4	30	30	153	cell differentiation;cell growth;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	metal ion binding;protein binding	HSPG2		ECM-receptor interaction; Hepatitis B; Proteoglycans in cancer	Integrin cell surface interactions; Defective B4GALT7 causes EDS, progeroid type; Amyloid fiber formation; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Non-integrin membrane-ECM interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD	0.522726336	0.012361368	0.024288311	FDR <= 0.05	21.77270919	21.93811175	21.72909441	21.77558672	21.71928889	22.18649421	22.52449841	22.80634339	21.76884669	22.26223994
Q06033	579	Q06033-2;Q06033;A0A087WW43;E7ET33	ITIH3	Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2	21	16	329	metabolic process;regulation of biological process;transport	extracellular;organelle lumen	enzyme regulator activity	ITIH3			Platelet degranulation	-1.315987673	2.04e-07	4.29e-06	FDR <= 0.01	25.40620509	25.46575525	25.30519988	25.41063384	25.29231437	24.10395965	24.08713	23.82980903	24.33308009	23.94619128
P01042-2	489	P01042-2;P01042-3;P01042	KNG1	Isoform LMW of Kininogen-1 OS=Homo sapiens OX=9606 GN=KNG1	22	22	376	cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	enzyme regulator activity;metal ion binding;protein binding	KNG1	ACE Inhibitor Pathway; Complement and Coagulation Cascades			-0.266895214	0.145778057	0.191977527	FDR > 0.05	26.70866038	26.72029452	26.63895174	26.69967347	26.481137	26.23433442	26.37960693	26.20718216	27.02275986	26.07035768
P01833	450	P01833	PIGR	Polymeric immunoglobulin receptor OS=Homo sapiens OX=9606 GN=PIGR PE=1 SV=4	18	18	198	cell organization and biogenesis;regulation of biological process;response to stimulus;transport	extracellular;membrane	receptor activity;signal transducer activity	PIGR		Intestinal immune network for IgA production	Neutrophil degranulation	0.921230885	0.006220357	0.013101094	FDR <= 0.05	24.27953858	24.30986791	24.17055431	24.2803684	24.13834313	25.56288954	25.39596883	23.97753573	25.43759607	25.41083659
P10909	683	P10909-6;P10909-4;P10909-2;P10909;P10909-5;H0YC35;H0YLK8;P10909-3;E7ERK6;E7ETB4;E5RH61;E5RJZ5;E5RGB0;E5RG36;H0YAS8	CLU	Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1	17	17	414	cell death;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;protein binding	CLU	Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Terminal pathway of complement; Antimicrobial peptides; Regulation of Complement cascade	-1.525967338	1.87e-05	9.58e-05	FDR <= 0.01	28.42874709	28.32824541	28.11742556	28.2887827	28.00843751	26.60006847	25.98933443	26.8934093	27.26073707	26.79825231
P23142-4	385	P23142-4;B1AHL2	FBLN1	Isoform C of Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1	13	4	175	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;metal ion binding;protein binding;structural molecule activity	FBLN1				0.363633191	0.004522378	0.009968682	FDR <= 0.01	20.53279673	20.60317142	20.54769635	20.58362172	20.61192811	20.96716807	20.74014752	21.14863964	20.8318205	21.00960457
P02760	51	P02760;S4R471;S4R3Y4	AMBP	Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP PE=1 SV=1	13	12	295	metabolic process;regulation of biological process;transport	cell surface;extracellular;membrane	enzyme regulator activity;protein binding	AMBP			Scavenging of heme from plasma	-1.040507539	1.71e-05	8.86e-05	FDR <= 0.01	26.23544811	26.22847215	26.1266609	26.15194755	26.0499444	25.29027833	25.35239827	24.83837739	25.34262988	24.76625154
P02790	660	P02790;Q9BS19	HPX	Hemopexin OS=Homo sapiens OX=9606 GN=HPX PE=1 SV=2	21	21	485	cellular homeostasis;metabolic process;regulation of biological process;transport	extracellular;organelle lumen	metal ion binding;protein binding;transporter activity	HPX			Scavenging of heme from plasma	0.039160962	0.684220339	0.725509497	FDR > 0.05	26.08074667	26.18320797	26.02925042	26.08912488	25.93986411	26.10992046	26.2231362	26.05930864	25.9790036	26.14662995
A0A7I2V2D2	170	P05155;P05155-3;A0A7I2V2D2;P05155-2;E9PGN7;H9KV48;A0A087WUD9;A0A7I2V5R3;A0A7I2V2X2;A0A7I2V4I9	SERPING1	Plasma protease C1 inhibitor OS=Homo sapiens OX=9606 GN=SERPING1 PE=4 SV=1	19	19	568								-0.792366889	4.8e-05	0.000200805	FDR <= 0.01	27.3324499	27.44907357	27.37810491	27.4182714	27.18509457	26.27621786	26.57384033	26.48329179	26.6130383	26.85477162
P07357	598	P07357	C8A	Complement component C8 alpha chain OS=Homo sapiens OX=9606 GN=C8A PE=1 SV=2	17	17	327	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	C8A	Allograft Rejection; Complement Activation	Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Amoebiasis	Terminal pathway of complement; Regulation of Complement cascade	-0.074631419	0.622911283	0.67208849	FDR > 0.05	25.5950671	25.59026777	25.53611932	25.50801563	25.35785295	24.95868949	25.66488451	25.72959935	25.37885153	25.48214078
P02748	713	P02748	C9	Complement component C9 OS=Homo sapiens OX=9606 GN=C9 PE=1 SV=2	22	22	308	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytosol;extracellular;membrane	protein binding	C9	Allograft Rejection; Complement Activation; Complement and Coagulation Cascades	Prion diseases; Complement and coagulation cascades; Amoebiasis; Systemic lupus erythematosus	Terminal pathway of complement; Regulation of Complement cascade	-1.660820581	1.03e-05	5.83e-05	FDR <= 0.01	27.02918576	27.09990363	26.86807714	26.96270893	26.83414649	25.29163804	24.47354642	25.40639535	25.52726536	25.79107388
P05156	40	G3XAM2;E7ETH0;P05156;A0A2R8Y3M9;A0A087X0I2;D6R9Z8	CFI	Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2	17	17	314	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;metal ion binding;protein binding;receptor activity	CFI	Complement and Coagulation Cascades	Complement and coagulation cascades; Staphylococcus aureus infection	Regulation of Complement cascade	2.966067897	4.57e-08	2.44e-06	FDR <= 0.01	23.91419111	23.97005005	23.84158875	23.87571312	23.85309315	27.1798467	26.224183	27.03542916	26.40773293	27.43778387
D6RF35	21	P02774;D6RF35;P02774-3;D6RBJ7;P02774-2;D6RF20	GC	Gc-globulin OS=Homo sapiens OX=9606 GN=GC PE=1 SV=1	22	22	223	transport	extracellular	transporter activity					0.217271104	0.064400914	0.09827931	FDR > 0.05	25.30394584	25.30272118	25.24147387	25.27911625	25.16424888	25.56304742	25.37280483	25.47412352	25.26623277	25.701653
P11021	437	P11021	HSPA5	Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2	22	20	132	cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	HSPA5	Parkin-Ubiquitin Proteasomal System pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; MAPK Signaling Pathway	Protein export; Thyroid hormone synthesis; Prion diseases; Protein processing in endoplasmic reticulum; Antigen processing and presentation	Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones	0.078657299	0.486030322	0.553534533	FDR > 0.05	22.72727037	22.64377309	22.62019948	22.70905434	22.5943894	22.608051	22.50792467	22.80271571	22.79078146	22.97850034
A0A5H1ZRQ3	201	A0A5H1ZRQ3	IGKC	Immunoglobulin kappa constant (Fragment) OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=1	12	3	1977								-0.089834434	0.48444058	0.553534533	FDR > 0.05	28.98776243	28.93087674	28.86631486	28.90891075	28.74849225	29.0310721	28.96842831	28.71863056	28.4541735	28.8208804
P05546	218	P05546	SERPIND1	Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERPIND1 PE=1 SV=3	18	17	515	coagulation;metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	enzyme regulator activity	SERPIND1	Complement and Coagulation Cascades	Complement and coagulation cascades	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation	-2.189446772	2.35e-06	1.85e-05	FDR <= 0.01	27.30927748	27.34079556	27.2618573	27.18794058	27.18748169	24.75062217	24.66953773	24.97307603	26.0812615	24.86562131
P02649	621	P02649;H0Y7L5;E9PEV4;E7ERP7	APOE	Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1	18	18	345	cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;nucleus;organelle lumen	antioxidant activity;catalytic activity;enzyme regulator activity;metal ion binding;protein binding;structural molecule activity;transporter activity	APOE	Vitamin B12 Metabolism; Alzheimers Disease; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin Pathway	Alzheimer's disease	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Retinoid metabolism and transport; Chylomicron remodeling; Scavenging by Class A Receptors; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; Signaling by GPCR; HDL remodeling; Chylomicron assembly; Chylomicron clearance	-1.362073456	0.000268011	0.000886166	FDR <= 0.01	27.87872416	27.77135818	27.7188439	27.89622444	27.66065214	26.28802818	25.48268066	26.67632697	26.5083199	27.16007982
P01834	180	P01834	IGKC	Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2	11	2	2352	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;protein binding	IGKC			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.086197284	0.60489516	0.661940433	FDR > 0.05	27.13716968	27.04380571	26.97792542	27.04274518	26.84915462	27.40948967	26.75935859	27.16142623	26.69786192	26.59167778
O00187	287	O00187;O00187-2	MASP2	Mannan-binding lectin serine protease 2 OS=Homo sapiens OX=9606 GN=MASP2 PE=1 SV=4	16	16	192	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	MASP2	Complement Activation; Complement and Coagulation Cascades	Complement and coagulation cascades; Staphylococcus aureus infection	Ficolins bind to repetitive carbohydrate structures on the target cell surface	1.578252699	1.04e-06	1.07e-05	FDR <= 0.01	22.64111135	22.71461137	22.57389008	22.68070044	22.63338037	24.34389793	24.58553804	23.80610429	23.90977923	24.4896376
P43652	720	P43652	AFM	Afamin OS=Homo sapiens OX=9606 GN=AFM PE=1 SV=1	25	25	306	transport	extracellular		AFM				-1.57333186	1.85e-06	1.6e-05	FDR <= 0.01	26.2370457	26.21701823	26.13304859	26.21604959	26.04838839	24.59974345	24.74445044	24.27833392	25.13840759	24.2239558
P26927	205	P26927;G3XAK1;Q2TV78;Q2TV78-2;H7C0F8	MST1	Hepatocyte growth factor-like protein OS=Homo sapiens OX=9606 GN=MST1 PE=1 SV=2	21	21	233	metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;protein binding	MST1			Signaling by MST1	-0.078832378	0.693786239	0.73186713	FDR > 0.05	23.53836293	23.55621448	23.46834681	23.50195972	23.45263175	22.95700556	24.09409876	23.26138272	23.66773258	23.14313418
P48740-2	342	P48740-4;P48740-2	MASP1	Isoform 2 of Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1	20	7	321	defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular	catalytic activity;metal ion binding;protein binding	MASP1	Complement Activation; Complement and Coagulation Cascades			1.41058585	2.92e-07	4.73e-06	FDR <= 0.01	23.96221085	24.01207333	23.91228204	24.03635348	23.87460242	25.47330318	25.50634722	25.44295668	24.94695863	25.48088566
A0A140T902	11	A0A140T8Y3;A0A140TA52;A0A140T902;P22105;A0A140TA33;P22105-1;P22105-4;A0A3B3ISX9;A0A140T9C0;A0A140TA41;A0A140T8Z8;A0A087X0I0;A0A140T9L7;P22105-2;Q16473;A0A140T956	TNXB	Tenascin-X OS=Homo sapiens OX=9606 GN=TNXB PE=1 SV=1	22	22	182	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	membrane	catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity					-0.723309185	7.5e-05	0.00029569	FDR <= 0.01	22.57861657	22.6425206	22.5722355	22.62134234	22.51918544	21.60692405	22.17378734	21.76171505	21.94707471	21.82785337
J3QSU6	69	P24821;P24821-4;J3QSU6;E9PC84;P24821-2;P24821-3;F5H7V9;P24821-5;P24821-6;H0YGZ3	TNC	Tenascin OS=Homo sapiens OX=9606 GN=TNC PE=1 SV=1	27	27	114	cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane;organelle lumen	protein binding	TNC	Focal Adhesion; TGF-beta Signaling Pathway; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway			0.547559173	0.000431988	0.001292845	FDR <= 0.01	22.43413658	22.46805077	22.39985341	22.43065276	22.30553281	22.87915719	23.01590193	22.94854441	22.71866664	23.21375202
P48740	34	P48740	MASP1	Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=3	19	6	292	defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular	catalytic activity;metal ion binding;protein binding	MASP1	Complement Activation; Complement and Coagulation Cascades	Complement and coagulation cascades; Staphylococcus aureus infection	Ficolins bind to repetitive carbohydrate structures on the target cell surface; Scavenging by Class A Receptors	1.857435583	9.53e-08	3.04e-06	FDR <= 0.01	22.34477938	22.34895116	22.39648014	22.23857304	22.29786348	24.10263177	24.10003089	23.98095523	23.99973703	24.7304702
P00488	698	P00488;Q9NQP5;A6PVK5;H0Y796	F13A1	Coagulation factor XIII A chain OS=Homo sapiens OX=9606 GN=F13A1 PE=1 SV=4	18	18	186	coagulation;metabolic process;response to stimulus;transport	cytoplasm;extracellular;organelle lumen	catalytic activity;metal ion binding	F13A1		Complement and coagulation cascades	Platelet degranulation ; Interleukin-4 and 13 signaling; Common Pathway of Fibrin Clot Formation	-0.096722626	0.570336516	0.627472196	FDR > 0.05	23.58928392	23.69082446	23.58473904	23.61470479	23.57338045	23.32156907	24.10534047	23.51115647	23.11335651	23.51789702
O43866	700	O43866	CD5L	CD5 antigen-like OS=Homo sapiens OX=9606 GN=CD5L PE=1 SV=1	16	16	616	cell death;defense response;response to stimulus;transport	cytoplasm;extracellular;membrane	receptor activity	CD5L				1.670546551	0.000173248	0.000605384	FDR <= 0.01	26.94391092	27.0703833	26.97546141	26.9297785	26.84783584	29.63808291	29.13239218	28.34252102	28.01084046	27.99626617
Q9UHG3	418	Q9UHG3;Q9UHG3-2;F8W8W4;C9K055;C9JM55;C9JGT6	PCYOX1	Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 GN=PCYOX1 PE=1 SV=3	15	15	133	metabolic process;transport	membrane;vacuole	catalytic activity;transporter activity	PCYOX1		Terpenoid backbone biosynthesis		-0.144133581	0.256810942	0.321013677	FDR > 0.05	22.84956505	22.98959918	22.84218279	22.91264579	22.83814068	22.56852868	22.44323458	22.85827047	22.88445695	22.95697491
P20851	262	P20851;P20851-2;Q5VVQ7	C4BPB	C4b-binding protein beta chain OS=Homo sapiens OX=9606 GN=C4BPB PE=1 SV=1	10	10	719	coagulation;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	C4BPB		Pertussis; Complement and coagulation cascades	Regulation of Complement cascade	1.561188755	2.09e-07	4.29e-06	FDR <= 0.01	26.6063984	26.74001269	26.59539542	26.65476093	26.53968379	28.26864007	27.89078962	28.15520106	28.03686416	28.59070009
G3V2B9	397	G3V2B9	SERPINA1	Alpha-1-antitrypsin (Fragment) OS=Homo sapiens OX=9606 GN=SERPINA1 PE=1 SV=1	12	1	662					NRF2 pathway; Lung fibrosis			-1.50416275	0.088527463	0.128104446	FDR > 0.05	18.00382942	18.1508675	18.20924898	17.7274252	21.78832398	17.80291175	16.53737457	16.24301128	19.06731936	16.70826437
P27918	501	P27918;E9PAQ1;C9J7V5	CFP	Properdin OS=Homo sapiens OX=9606 GN=CFP PE=1 SV=2	12	12	311	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	CFP	Complement Activation	Herpes simplex infection	Alternative complement activation; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins	2.389459134	2.01e-06	1.67e-05	FDR <= 0.01	24.17409364	24.19213054	24.10366032	24.14066097	24.02232708	27.16654463	26.96965961	25.55388731	26.4962197	26.39385698
P0DOY3	511	P0DOY3	IGLC3	Immunoglobulin lambda constant 3 OS=Homo sapiens OX=9606 GN=IGLC3 PE=1 SV=1	10	5	1696	response to stimulus	extracellular;membrane		IGLC3			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.09536603	0.648106753	0.694400093	FDR > 0.05	29.493511	29.45038601	29.43608369	29.48010591	29.3828556	30.25596162	29.34186324	29.79663742	29.07143676	29.25387332
P14923	442	P14923;C9JK18;C9JKY1;C9J826;C9JTX4;A0A2R8Y7Z0;A0A2R8Y5Z1;A0A2R8Y750;A0A2R8Y804;A0A2R8YCH5;A0A2R8Y5A3;P35222;A0A2R8Y543;B4DGU4;A0A2R8Y5C3;A0A2R8Y6G0	JUP	Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3	21	21	129	cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	protein binding;signal transducer activity;structural molecule activity	JUP	Arrhythmogenic Right Ventricular Cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Ectoderm Differentiation	Pathways in cancer; Acute myeloid leukemia; Transcriptional misregulation in cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability	0.465134895	0.165299974	0.215380262	FDR > 0.05	22.99710713	22.19164701	21.98614237	22.68284644	22.144163	22.870943	23.61353533	23.0524344	22.97165897	21.81900873
Q08380	723	Q08380;K7EP36;K7EKQ5;K7ESM3;K7EJD3;K7ERZ6;K7EJY8	LGALS3BP	Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1	16	16	247	defense response;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	protein binding;receptor activity	LGALS3BP			Platelet degranulation	1.256340205	1.2e-05	6.53e-05	FDR <= 0.01	23.25714027	23.44363626	23.27529107	23.38306636	23.16243328	24.86948959	24.92400034	24.42279607	24.06302743	24.52395484
A0A0B4J231	190	B9A064;A0A0B4J231;A0A5H1ZRQ4;P0CG04	IGLL5	Immunoglobulin lambda-like polypeptide 5 OS=Homo sapiens OX=9606 GN=IGLL5 PE=1 SV=1	10	3	1250	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding	IGLL5				-0.032112293	0.841399926	0.863874716	FDR > 0.05	29.58522904	29.4777724	29.43940817	29.47875982	29.32541591	29.99060724	29.29980465	29.46660579	29.14526849	29.24373772
P04217-2	685	P04217-2	A1BG	Isoform 2 of Alpha-1B-glycoprotein OS=Homo sapiens OX=9606 GN=A1BG	11	8	209	transport	extracellular;organelle lumen	protein binding	A1BG				-2.27260456	3.76e-07	5.52e-06	FDR <= 0.01	25.29629873	25.31141868	25.13508239	25.3197945	25.21950846	22.86261341	22.9243843	22.64141748	23.81938731	22.67127747
P35858	636	P35858;P35858-2	IGFALS	Insulin-like growth factor-binding protein complex acid labile subunit OS=Homo sapiens OX=9606 GN=IGFALS PE=1 SV=1	17	17	303	metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	IGFALS			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-1.833607598	7.82e-07	8.38e-06	FDR <= 0.01	24.49490647	24.58757739	24.49108478	24.53091949	24.43007165	22.69607084	22.73536189	22.31865669	23.30941265	22.30701973
P11717	425	P11717;A0A7I2V381;A0A7I2YQS7;S4R328	IGF2R	Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3	26	26	119	cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endosome;Golgi;membrane;nucleus;vacuole	catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity	IGF2R		Endocytosis; Lysosome	Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis	0.437684658	0.00035444	0.001129434	FDR <= 0.01	21.1930777	21.26055484	21.22429598	21.29546888	21.19324932	21.75200878	21.69652334	21.64471868	21.58145563	21.68036357
P04004	123	P04004;F5GX75	VTN	Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 SV=1	11	11	504	cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;extracellular;organelle lumen	protein binding;receptor activity	VTN	Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway; Senescence and Autophagy in Cancer	Complement and coagulation cascades; PI3K-Akt signaling pathway; Proteoglycans in cancer; ECM-receptor interaction; Focal adhesion	ECM proteoglycans; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Complement cascade; Syndecan interactions	-1.707201066	4.68e-06	3.13e-05	FDR <= 0.01	29.01726409	28.84539211	28.68463124	28.95690355	28.77945013	27.15265722	27.3253578	26.68805161	27.81465565	26.76691352
P60709	405	P63261;P60709;E7EVS6;A0A6Q8PFE4;A0A2R8Y793;I3L3I0;I3L4N8;A0A2R8YGF8;I3L3R2;A0A6Q8PH58;J3KT65;G5E9R0;K7EM38;A0A2R8YEA7;A5A3E0;Q6S8J3;A0A2R8YFE2;Q9BYX7;P0CG39;P0CG38	ACTB	Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1	13	6	169	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	DNA binding;nucleotide binding;protein binding;structural molecule activity	ACTB	Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; Focal Adhesion; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Regulation of Actin Cytoskeleton	Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hypertrophic cardiomyopathy (HCM); Thyroid hormone signaling pathway; Vibrio cholerae infection; Hippo signaling pathway; Leukocyte transendothelial migration; Tight junction; Salmonella infection; Shigellosis; Apoptosis; Influenza A; Oxytocin signaling pathway; Bacterial invasion of epithelial cells; Dilated cardiomyopathy; Regulation of actin cytoskeleton; Proteoglycans in cancer; Phagosome; Rap1 signaling pathway; Pathogenic Escherichia coli infection; Platelet activation; Viral myocarditis; Gastric acid secretion; Adherens junction	Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate  to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression	0.322481972	0.263201259	0.328243016	FDR > 0.05	22.38761882	22.36709019	22.28542492	22.47531561	22.52137826	22.43317947	22.663892	22.26045656	23.8927735	22.39893612
Q9BXR6	564	Q9BXR6	CFHR5	Complement factor H-related protein 5 OS=Homo sapiens OX=9606 GN=CFHR5 PE=1 SV=1	16	15	115	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	CFHR5			Regulation of Complement cascade	0.209951872	0.137221114	0.182269946	FDR > 0.05	22.88782434	22.906228	22.83533101	22.8743478	22.7222669	23.07797941	23.46640134	22.77119385	23.01132966	22.94885315
P12111	272	P12111;P12111-2;E7ENL6;P12111-4;P12111-5;P12111-3;C9JNG9	COL6A3	Collagen alpha-3(VI) chain OS=Homo sapiens OX=9606 GN=COL6A3 PE=1 SV=5	25	25	118	cell organization and biogenesis;metabolic process;regulation of biological process	extracellular;membrane;organelle lumen	enzyme regulator activity;protein binding	COL6A3	miRNA targets in ECM and membrane receptors	ECM-receptor interaction; PI3K-Akt signaling pathway; Protein digestion and absorption; Focal adhesion	ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF	0.299697339	0.040946835	0.066444072	FDR > 0.05	21.18958789	21.28890428	21.15421061	21.25750114	21.16163216	21.36200601	21.54870725	21.8048598	21.16122231	21.67352741
P08697	89	P08697;P08697-2;A0A0G2JPA8;C9JMH6;C9JPV4;A0A0J9YY65;A0A0J9YWQ3	SERPINF2	Alpha-2-antiplasmin OS=Homo sapiens OX=9606 GN=SERPINF2 PE=1 SV=3	14	14	200	cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport	cell surface;extracellular;organelle lumen	enzyme regulator activity;protein binding	SERPINF2	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Dissolution of Fibrin Clot	-1.629942211	1.14e-07	3.04e-06	FDR <= 0.01	25.58834063	25.5399505	25.42990604	25.47997397	25.36552959	23.64838921	24.02581088	23.59114753	24.18873156	23.7999105
P02749	651	P02749;J3QRN2;J3QLI0;J3KS17	APOH	Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 GN=APOH PE=1 SV=3	13	13	279	metabolic process;regulation of biological process;response to stimulus;transport	cell surface;extracellular;organelle lumen	enzyme regulator activity;protein binding	APOH			Platelet degranulation	1.058854979	6.2e-06	3.89e-05	FDR <= 0.01	23.86955943	23.82546538	23.74765221	23.76828222	23.58580858	24.7605776	24.81130304	24.48914831	24.8836414	25.14637238
P02765	79	P02765;C9JV77	AHSG	Alpha-2-HS-glycoprotein OS=Homo sapiens OX=9606 GN=AHSG PE=1 SV=2	9	9	179								-0.644330859	0.013736986	0.02640077	FDR <= 0.05	25.22076038	25.2809263	25.12211814	25.19844373	25.09187849	24.37698638	25.38654824	24.08706397	24.64464437	24.19722979
Q02413	335	Q02413;Q02413-2	DSG1	Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2	17	17	135	cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoskeleton;cytosol;membrane	metal ion binding;protein binding	DSG1		Staphylococcus aureus infection	Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation	0.344168118	0.196360174	0.249507246	FDR > 0.05	22.36276681	22.12101404	21.77862329	22.19973521	21.90138926	22.11039379	23.10500258	22.75176083	22.46556221	21.6516498
P04040	706	P04040	CAT	Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3	17	17	136	cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion;organelle lumen;vacuole	antioxidant activity;catalytic activity;metal ion binding;nucleotide binding;protein binding	CAT	Selenium Micronutrient Network; Folate Metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative Stress; Tryptophan metabolism; DNA Damage Response (only ATM dependent)	Tryptophan metabolism; Longevity regulating pathway - multiple species; Amyotrophic lateral sclerosis (ALS); Carbon metabolism; Peroxisome; Longevity regulating pathway; Glyoxylate and dicarboxylate metabolism; FoxO signaling pathway	Neutrophil degranulation; Detoxification of Reactive Oxygen Species	1.586253591	1.12e-07	3.04e-06	FDR <= 0.01	21.79834103	21.89920928	21.8423268	21.8945936	21.85641708	23.65142697	23.55654034	23.40288847	23.02349427	23.58780569
Q03591	681	Q03591;B1AKG0	CFHR1	Complement factor H-related protein 1 OS=Homo sapiens OX=9606 GN=CFHR1 PE=1 SV=2	14	2	383	metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	CFHR1			Regulation of Complement cascade	1.445699852	3.8e-06	2.75e-05	FDR <= 0.01	23.02932382	23.05041421	22.94308026	23.01119721	22.76596298	24.03696294	24.11124432	24.80232017	24.31678929	24.76116103
P01880	413	A0A0A0MS09;P01880;P01880-2	IGHD	Immunoglobulin heavy constant delta OS=Homo sapiens OX=9606 GN=IGHD PE=1 SV=3	12	12	324	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHD			CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	-0.989604528	0.002166079	0.005393274	FDR <= 0.01	24.85355508	24.74391085	24.68737419	24.76156047	24.62803863	24.650454	23.87583785	23.27424998	23.77469149	23.15118325
Q15582	183	Q15582;H0Y8L3;S4R3C6;H0Y9D7;H0Y8M8;H0YAB8	TGFBI	Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1	16	16	126	cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	TGFBI			Amyloid fiber formation	0.325261286	0.045254165	0.072477374	FDR > 0.05	21.64305751	21.58570077	21.53268254	21.63179916	21.47017772	22.02432911	22.35371069	21.81425461	21.61383468	21.68359503
P36980	115	A0A3B3IQ51;P36980;P36980-2;V9GYE7;A0A3B3ISW6;A0A3B3IS00;A0A3B3IRW0;A0A3B3IS28	CFHR2	Complement factor H-related protein 2 OS=Homo sapiens OX=9606 GN=CFHR2 PE=1 SV=1	12	6	229	regulation of biological process	extracellular	protein binding	CFHR2			Regulation of Complement cascade	1.280717241	1.19e-05	6.51e-05	FDR <= 0.01	23.97844326	23.88768748	23.91398002	23.58490039	23.77352576	24.58749697	25.04319455	25.32020272	25.09077743	25.50045144
P36955	597	P36955;I3L4N7;I3L107;I3L4F9;I3L4Z0;I3L2R7	SERPINF1	Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4	12	9	168	cell proliferation;cellular homeostasis;development;regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;protein binding	SERPINF1		Wnt signaling pathway		-2.31138713	2.5e-07	4.58e-06	FDR <= 0.01	25.61176701	25.57726368	25.48393709	25.5732313	25.43310751	22.98490434	23.2463297	23.14450421	23.99442985	22.75220284
P25311	374	P25311;C9JEV0	AZGP1	Zinc-alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=AZGP1 PE=1 SV=2	16	16	113	metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;nucleus	catalytic activity;protein binding;transporter activity	AZGP1			Miscellaneous transport and binding events	0.51576707	0.000468858	0.001379655	FDR <= 0.01	23.74928644	23.77559195	23.64065655	23.71740133	23.61447084	24.16946492	24.43327947	24.03189271	24.30906001	24.13254534
P12814	352	P12814;P12814-3;P12814-4;H9KV75;P12814-2;A0A7I2V4Y4;H7C5W8;A0A494C1A0;A0A494C060;P35609;P35609-2;H0YJ11;Q08043;A0A087WSZ2;H0YJW3;G3V2W4;G3V2N5;G3V2X9	ACTN1	Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2	18	9	87	cell differentiation;cell organization and biogenesis;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen	metal ion binding;protein binding;RNA binding	ACTN1	Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Regulation of Actin Cytoskeleton	Amoebiasis; Regulation of actin cytoskeleton; Tight junction; Viral carcinogenesis; Systemic lupus erythematosus; Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Leukocyte transendothelial migration; Focal adhesion	Platelet degranulation ; Nephrin family interactions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components; Syndecan interactions	1.440613163	4.16e-05	0.000178813	FDR <= 0.01	20.08674047	20.2064507	20.12679916	20.33104032	20.33491187	21.58140211	21.1978701	21.19302274	21.95606206	22.36065133
O14791	389	O14791-2;O14791;O14791-3;B1AH96	APOL1	Apolipoprotein L1 OS=Homo sapiens OX=9606 GN=APOL1 PE=1 SV=5	16	16	229	defense response;metabolic process;response to stimulus;transport	extracellular;organelle lumen	protein binding;transporter activity	APOL1		African trypanosomiasis	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma	-0.04221315	0.840877912	0.863874716	FDR > 0.05	25.10594263	25.11484792	24.96781931	24.99536962	24.98342638	25.70290913	25.23400929	24.49541018	24.84226846	24.68174303
P14543	624	P14543;P14543-2	NID1	Nidogen-1 OS=Homo sapiens OX=9606 GN=NID1 PE=1 SV=3	18	18	115	cell organization and biogenesis;regulation of biological process	cell surface;extracellular;membrane	metal ion binding;protein binding	NID1			Laminin interactions; Degradation of the extracellular matrix	1.268808787	0.003214791	0.007633576	FDR <= 0.01	21.10546751	21.20172627	21.14829717	21.14255156	21.30097205	22.40533843	21.52883782	23.44984352	21.74419114	23.11484759
P02745	689	P02745;X6RLJ0	C1QA	Complement C1q subcomponent subunit A OS=Homo sapiens OX=9606 GN=C1QA PE=1 SV=2	6	6	158	cell communication;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	C1QA	Allograft Rejection; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades	Staphylococcus aureus infection; Pertussis; Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Chagas disease (American trypanosomiasis)	Regulation of Complement cascade; Classical antibody-mediated complement activation	2.058620285	9.41e-09	1.93e-06	FDR <= 0.01	24.41121713	24.23190462	24.19946259	24.27359453	24.0638756	26.58302299	26.21444036	26.0669853	26.11672516	26.4919821
O75882	104	O75882-2;O75882-3;O75882	ATRN	Attractin OS=Homo sapiens OX=9606 GN=ATRN PE=1 SV=2	16	16	110	defense response;regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane	protein binding;receptor activity	ATRN				-0.108904437	0.29077669	0.356941446	FDR > 0.05	21.97349227	22.17624663	22.11782757	22.17104403	22.17521195	22.09948309	22.08415422	21.81461105	22.08042437	21.99062752
P29622	654	P29622	SERPINA4	Kallistatin OS=Homo sapiens OX=9606 GN=SERPINA4 PE=1 SV=3	14	14	231	regulation of biological process;transport	extracellular;organelle lumen	enzyme regulator activity	SERPINA4			Platelet degranulation	-1.944927131	9.33e-06	5.52e-05	FDR <= 0.01	25.39467549	25.45903182	25.3659606	25.44122743	25.33160423	23.21312966	23.72611812	22.94336886	24.37415853	23.01108874
C9JU00	478	C9JU00;C9JPQ9	FGG	Fibrinogen gamma chain (Fragment) OS=Homo sapiens OX=9606 GN=FGG PE=1 SV=1	12	1	276	cell organization and biogenesis;regulation of biological process;response to stimulus		protein binding		Blood Clotting Cascade			1.272460023	0.083962878	0.122665136	FDR > 0.05	20.68815416	20.72596247	20.7110647	20.65373033	20.66343205	20.22490515	24.80690498	21.64090923	21.80663792	21.32528655
Q16610	724	Q16610;Q16610-4;Q16610-2;Q16610-3	ECM1	Extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=ECM1 PE=1 SV=2	14	14	195	defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding;signal transducer activity	ECM1			Platelet degranulation	1.71720293	0.000372304	0.00117419	FDR <= 0.01	22.77670606	22.8412074	22.83383835	22.78550619	22.72757475	23.95660344	25.95996255	24.35907762	23.91728025	24.35792355
Q96KN2	98	Q96KN2;J3KRP0	CNDP1	Beta-Ala-His dipeptidase OS=Homo sapiens OX=9606 GN=CNDP1 PE=1 SV=4	14	14	163	metabolic process;regulation of biological process	cytosol;extracellular	catalytic activity;metal ion binding	CNDP1		Metabolic pathways; Arginine and proline metabolism; Histidine metabolism; beta-Alanine metabolism		-1.573346209	1.29e-07	3.18e-06	FDR <= 0.01	23.7946296	23.85885953	23.73897202	23.78731303	23.70452007	22.2426378	21.97444723	22.1124537	22.61887289	22.06915158
P03951	43	P03951;P03951-2;X6R3B1;D6RB32;H0Y596	F11	Coagulation factor XI OS=Homo sapiens OX=9606 GN=F11 PE=1 SV=1	17	17	124	coagulation;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	F11	Blood Clotting Cascade	Complement and coagulation cascades	Intrinsic Pathway of Fibrin Clot Formation	-0.812897219	0.000729352	0.002048179	FDR <= 0.01	23.38226109	23.41060549	23.33860143	23.47111414	23.22073957	22.65331946	22.96917972	22.15506991	22.84104924	22.14021729
Q02985	132	Q02985-2;Q02985;Q6NSD3;A0A087WYK9	CFHR3	Complement factor H-related protein 3 OS=Homo sapiens OX=9606 GN=CFHR3 PE=1 SV=2	8	2	162		extracellular		CFHR3			Regulation of Complement cascade	0.718427373	3.14e-05	0.00014213	FDR <= 0.01	20.83928221	20.86066357	20.82475338	20.80034611	20.68974432	21.3787616	21.51204024	21.78085115	21.39864103	21.53663243
A0A0A0MSV6	178	A0A0A0MSV6;P02746;D6R934	C1QB	Complement C1q subcomponent subunit B (Fragment) OS=Homo sapiens OX=9606 GN=C1QB PE=1 SV=6	5	5	597	response to stimulus	extracellular;membrane	protein binding		Spinal Cord Injury; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage			1.563038456	4.81e-07	6.43e-06	FDR <= 0.01	24.45350609	24.46945402	24.29163827	24.52556511	24.28841308	26.20994696	25.86139342	25.85697733	25.59604218	26.31940897
O00391	637	O00391;O00391-2;A8MXT8	QSOX1	Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 GN=QSOX1 PE=1 SV=3	16	16	127	cellular homeostasis;metabolic process;regulation of biological process;transport	extracellular;Golgi;membrane;organelle lumen	catalytic activity	QSOX1			Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation	-0.930192997	4.45e-05	0.000188612	FDR <= 0.01	22.3677293	22.43538544	22.34003007	22.38978781	22.23619909	21.27378381	21.67669269	21.11234225	21.78132742	21.27402056
P14780	673	P14780	MMP9	Matrix metalloproteinase-9 OS=Homo sapiens OX=9606 GN=MMP9 PE=1 SV=3	15	15	80	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular	catalytic activity;metal ion binding;protein binding	MMP9	Matrix Metalloproteinases; Osteopontin Signaling; Angiogenesis; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; AGE/RAGE pathway; Spinal Cord Injury; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; Lung fibrosis; Endochondral Ossification	Bladder cancer; Pathways in cancer; Transcriptional misregulation in cancer; Hepatitis B; Endocrine resistance; Leukocyte transendothelial migration; Proteoglycans in cancer; MicroRNAs in cancer; Estrogen signaling pathway; TNF signaling pathway	Collagen degradation; EPH-ephrin mediated repulsion of cells; Neutrophil degranulation; Assembly of collagen fibrils and other multimeric structures; Activation of Matrix Metalloproteinases; Signaling by SCF-KIT; Interleukin-4 and 13 signaling	1.75244303	0.000132416	0.000476232	FDR <= 0.01	19.9776211	20.14787521	20.05756571	20.10904509	20.2844271	21.27726181	21.4072065	21.55376979	23.09373372	22.00677753
P80108	214	P80108;P80108-2	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D OS=Homo sapiens OX=9606 GN=GPLD1 PE=1 SV=3	15	15	174	cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;membrane	catalytic activity	GPLD1		Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	Post-translational modification: synthesis of GPI-anchored proteins	-0.967687805	1.26e-06	1.16e-05	FDR <= 0.01	23.68852343	23.76796869	23.67043736	23.75762003	23.64968836	22.70593194	22.62921155	22.63519968	22.98144577	22.7440099
M0R009	640	M0R009	A1BG	Alpha-1B-glycoprotein (Fragment) OS=Homo sapiens OX=9606 GN=A1BG PE=1 SV=8	9	6	281			protein binding					-0.50135557	0.005293821	0.011463731	FDR <= 0.05	25.33567559	25.25483547	25.15652631	25.26715606	25.07937378	24.77261526	24.37527129	24.52351801	24.77732328	25.13806151
D6RAR4	228	Q04756;D6RAR4	HGFAC	Hepatocyte growth factor activator OS=Homo sapiens OX=9606 GN=HGFAC PE=1 SV=1	12	12	94	metabolic process	cytoplasm;cytosol;endoplasmic reticulum;extracellular	catalytic activity	HGFAC				-0.417599265	0.005707977	0.012104848	FDR <= 0.05	22.33185824	22.47642298	22.32805153	22.33515565	22.34409885	22.13627721	21.64287513	22.18392039	21.96041436	21.80410384
P05090	298	C9JF17;P05090;C9JX71	APOD	Apolipoprotein D OS=Homo sapiens OX=9606 GN=APOD PE=1 SV=1	9	9	363	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;extracellular;ribosome	protein binding;transporter activity	APOD			Transport of fatty acids	-0.548456297	0.017967507	0.032773413	FDR <= 0.05	26.01847658	26.02986231	25.92457768	26.04836258	25.900277	25.32604499	24.68832492	25.81307828	25.61477527	25.73705123
P15169	224	P15169;B1AP58	CPN1	Carboxypeptidase N catalytic chain OS=Homo sapiens OX=9606 GN=CPN1 PE=1 SV=1	12	12	233	metabolic process;regulation of biological process;response to stimulus	extracellular;Golgi	catalytic activity;metal ion binding	CPN1	Steroid Biosynthesis		Insulin processing; Regulation of Complement cascade	-1.868218605	1.01e-07	3.04e-06	FDR <= 0.01	24.12821138	24.12520588	24.02204447	24.03274379	23.89382664	22.06878803	22.14221237	21.92907158	22.70425276	22.0166144
P35555	257	P35555;H0YND0;A0A6I8PL22	FBN1	Fibrillin-1 OS=Homo sapiens OX=9606 GN=FBN1 PE=1 SV=4	14	14	57	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;membrane;organelle lumen	metal ion binding;protein binding;structural molecule activity	FBN1	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease			0.641226168	0.001061011	0.002849441	FDR <= 0.01	20.85091044	20.89212662	20.81456941	20.89766619	20.81251648	21.10775929	21.81961063	21.7483138	21.2613459	21.53689036
P24043	216	P24043;A0A087WYF1;A0A087WX80	LAMA2	Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4	20	20	103	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;extracellular;membrane	catalytic activity;motor activity;protein binding;signal transducer activity;structural molecule activity	LAMA2	Arrhythmogenic Right Ventricular Cardiomyopathy; Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	Toxoplasmosis; PI3K-Akt signaling pathway; Amoebiasis; Focal adhesion; Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Small cell lung cancer; Dilated cardiomyopathy; ECM-receptor interaction; Pathways in cancer; Viral myocarditis	ECM proteoglycans; Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	0.986157979	1.1e-05	6.14e-05	FDR <= 0.01	20.21243373	20.31218923	20.1891763	20.22167278	20.21079045	21.19936011	21.34050642	21.5613884	20.90310737	21.07269008
E7EQB2	527	E7EQB2;P02788-2;E7ER44;P02788	LTF	Lactotransferrin (Fragment) OS=Homo sapiens OX=9606 GN=LTF PE=1 SV=1	15	14	60	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding					0.707184939	0.172601609	0.223683902	FDR > 0.05	19.82189091	19.79578243	19.787063	19.86478604	21.92009019	20.58616068	21.60953536	20.24052512	21.9660874	20.32322872
Q92954-3	431	Q92954-3;Q92954-4;Q92954;Q92954-6;Q92954-2;Q92954-5;J3KP74;E9PLR3	PRG4	Isoform C of Proteoglycan 4 OS=Homo sapiens OX=9606 GN=PRG4	19	19	121								-0.241400908	0.211418849	0.267536197	FDR > 0.05	23.28374068	23.25499433	23.16455942	23.2898327	23.10468117	23.4257118	23.35777591	22.96695813	22.60751244	22.53284547
P19013	682	P19013	KRT4	Keratin, type II cytoskeletal 4 OS=Homo sapiens OX=9606 GN=KRT4 PE=1 SV=5	17	10	96								0.538058495	0.397522833	0.471962437	FDR > 0.05	21.15783792	20.77572981	20.27502084	23.32320072	20.4623901	21.76047359	21.48093446	23.30540461	20.74726192	21.3903973
Q8N1N4	670	Q8N1N4;Q8N1N4-2	KRT78	Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2	16	13	89	cell death	cytosol	structural molecule activity	KRT78			Formation of the cornified envelope	0.640819338	0.008480443	0.017212781	FDR <= 0.05	20.68820436	20.52480372	20.20700099	20.70319425	20.32715811	20.8205768	21.60444671	21.32110005	21.32141948	20.58691507
A0A5H1ZRQ7	370	A0M8Q6;A0A5H1ZRQ7	IGLC7	Immunoglobulin lambda constant 7 (Fragment) OS=Homo sapiens OX=9606 GN=IGLC7 PE=1 SV=1	9	4	988								-0.205639548	0.499400421	0.562511463	FDR > 0.05	23.11148663	22.97375277	22.62510245	22.86238395	22.48534105	23.45474744	22.76983067	21.54863602	22.64480725	22.61184774
A0A087WT59	440	P02766;A0A087WT59	TTR	Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=2	5	5	70								-0.170485727	0.184515995	0.23690467	FDR > 0.05	23.08149298	23.11138694	23.04603313	22.95629233	22.90643722	22.95052918	22.46954376	22.98286694	22.88793421	22.95833987
F8W876	497	P48740-3;F8W876	MASP1	Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=1	12	1	210	defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular	catalytic activity;metal ion binding;protein binding	MASP1	Complement Activation; Complement and Coagulation Cascades			1.317027275	2.69e-07	4.59e-06	FDR <= 0.01	17.86379897	18.0532697	17.97432396	17.74433907	18.06796358	19.09412023	19.20856921	19.46501421	19.12182109	19.39930692
Q15166	607	Q15166;F8WD41;C9JZ99	PON3	Serum paraoxonase/lactonase 3 OS=Homo sapiens OX=9606 GN=PON3 PE=1 SV=3	12	10	117	metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	PON3	Phase I biotransformations, non P450	Metabolic pathways	Synthesis of 5-eicosatetraenoic acids	-1.362322856	0.000525569	0.001524647	FDR <= 0.01	27.77108685	27.75539269	27.77321764	27.76296969	27.580289	25.76686979	25.50287846	26.70570364	26.98575578	26.87013392
P07360	634	P07360;A0A3B3ITK5	C8G	Complement component C8 gamma chain OS=Homo sapiens OX=9606 GN=C8G PE=1 SV=3	9	9	161	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	protein binding	C8G	Complement Activation; Complement and Coagulation Cascades	Prion diseases; Systemic lupus erythematosus; Complement and coagulation cascades; Amoebiasis	Terminal pathway of complement; Regulation of Complement cascade	0.045399493	0.73744745	0.771309833	FDR > 0.05	23.81744476	23.76338027	23.74259041	23.75457474	23.66324173	23.39108051	23.81863635	24.08019548	23.71061702	23.96770002
E9PEP6	668	O14786;E9PEP6;E7EX60;O14786-2;Q5T7F0;O14786-3;Q5JWQ4;Q5JWQ6;H0Y4A0	NRP1	Neuropilin OS=Homo sapiens OX=9606 GN=NRP1 PE=1 SV=2	12	12	69	cell communication;cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus;transport	cell surface;cytosol;endosome;membrane	catalytic activity;enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity	NRP1				0.919044374	3.94e-06	2.79e-05	FDR <= 0.01	20.43654704	20.4193691	20.36184148	20.3138958	20.36305855	21.07867842	21.15050567	21.3617438	21.4846224	21.41438355
P51884	248	P51884	LUM	Lumican OS=Homo sapiens OX=9606 GN=LUM PE=1 SV=2	10	10	211	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	protein binding;structural molecule activity	LUM		Proteoglycans in cancer	ECM proteoglycans; Integrin cell surface interactions; Keratan sulfate biosynthesis; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Keratan sulfate degradation; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	-2.196365559	6.65e-07	7.86e-06	FDR <= 0.01	24.4406253	24.54820304	24.46962777	24.54191016	24.36215353	22.2554634	22.13562205	21.83456525	23.12121334	22.03382797
O95678	285	O95678	KRT75	Keratin, type II cytoskeletal 75 OS=Homo sapiens OX=9606 GN=KRT75 PE=1 SV=2	19	1	117	cell death;cell differentiation	cytosol	catalytic activity;motor activity;structural molecule activity	KRT75			Formation of the cornified envelope	0.753437151	0.003350817	0.007835561	FDR <= 0.01	14.08127708	14.51703621	14.27639998	14.18760034	14.80084337	15.17706409	15.10355621	14.78805842	14.83387784	15.72778619
P05543	312	P05543	SERPINA7	Thyroxine-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA7 PE=1 SV=2	10	10	142	regulation of biological process;transport	extracellular	enzyme regulator activity	SERPINA7		Thyroid hormone synthesis		-1.668057448	2.61e-07	4.58e-06	FDR <= 0.01	23.82179167	23.91596909	23.81463697	23.83503854	23.75506858	22.12575784	22.10239922	21.83033911	22.67053219	22.07318925
O75636	696	O75636;O75636-2	FCN3	Ficolin-3 OS=Homo sapiens OX=9606 GN=FCN3 PE=1 SV=2	10	10	223	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	FCN3			Ficolins bind to repetitive carbohydrate structures on the target cell surface	1.984030633	3.32e-07	5.24e-06	FDR <= 0.01	23.36908865	23.50705673	23.34963807	23.3690665	23.29026868	25.64390971	25.60066469	25.0141514	24.84355342	25.70299257
O95445	642	O95445;Q5SRP5;O95445-2	APOM	Apolipoprotein M OS=Homo sapiens OX=9606 GN=APOM PE=1 SV=2	7	7	127	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	extracellular	antioxidant activity;catalytic activity;transporter activity	APOM			Signaling by GPCR; Retinoid metabolism and transport	0.115160092	0.488959991	0.554816226	FDR > 0.05	23.13838436	23.15451939	23.00677796	23.10861745	22.96680001	23.16764273	22.82095699	23.28940673	22.94909605	23.72379713
P49747	475	G3XAP6;P49747;P49747-2	COMP	Cartilage oligomeric matrix protein OS=Homo sapiens OX=9606 GN=COMP PE=1 SV=2	12	11	117	cell death;cell organization and biogenesis;regulation of biological process	extracellular	metal ion binding;protein binding;structural molecule activity	COMP	Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	PI3K-Akt signaling pathway; Phagosome; Malaria; ECM-receptor interaction; Focal adhesion	ECM proteoglycans; Integrin cell surface interactions	-0.665623642	0.015888758	0.029610867	FDR <= 0.05	22.08292293	22.05387743	22.02362947	22.22047799	22.03271135	21.13081464	20.81773621	22.29767872	21.31483783	21.52443355
Q9Y490	209	Q9Y490	TLN1	Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3	15	15	52	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane	protein binding;structural molecule activity	TLN1	Integrin-mediated Cell Adhesion; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion	Platelet activation; HTLV-I infection; Focal adhesion; Rap1 signaling pathway	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; XBP1(S) activates chaperone genes; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling	0.598079699	0.002558934	0.006245018	FDR <= 0.01	19.05227115	19.05486876	19.0500016	19.16646899	19.1418655	19.68350236	19.43837487	19.30256405	19.93911964	20.09231357
F5GXS2	99	F5GXS2;O43707;O43707-2;H7C144;O43707-3	ACTN4	Actinin, alpha 4, isoform CRA_a OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=3	14	5	80								0.838574108	0.000980465	0.002644675	FDR <= 0.01	17.48685236	17.52629798	17.71591809	17.8508415	18.02330939	18.34822814	18.23566798	18.29453544	19.03951528	18.87814303
P35443	267	P35443;E7ES19	THBS4	Thrombospondin-4 OS=Homo sapiens OX=9606 GN=THBS4 PE=1 SV=2	14	12	111	cellular component movement;regulation of biological process;response to stimulus	endoplasmic reticulum;extracellular	metal ion binding;protein binding	THBS4	Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; Malaria; Phagosome	Signaling by PDGF	0.645307768	0.103581847	0.145108965	FDR > 0.05	21.79813816	21.80762383	21.70659642	21.83607497	21.71653288	22.36476743	21.56388988	23.91139603	21.83386048	22.41759127
Q9NZP8	311	Q9NZP8;H0YFL7;F5GWF3;F5H6S5;F5H7C8	C1RL	Complement C1r subcomponent-like protein OS=Homo sapiens OX=9606 GN=C1RL PE=1 SV=2	11	9	130	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity	C1RL				-1.675338892	1.23e-07	3.14e-06	FDR <= 0.01	23.10347777	23.1236955	23.02553838	23.0960063	22.99906096	21.40657653	21.32003605	21.15974144	21.86131748	21.22341297
P27169	75	P27169	PON1	Serum paraoxonase/arylesterase 1 OS=Homo sapiens OX=9606 GN=PON1 PE=1 SV=3	10	8	159	metabolic process;regulation of biological process;response to stimulus	extracellular	antioxidant activity;catalytic activity;metal ion binding;protein binding	PON1	Phase I biotransformations, non P450	Metabolic pathways	Synthesis of 5-eicosatetraenoic acids	-1.667463163	0.000168145	0.00059091	FDR <= 0.01	25.40022675	25.38810701	25.2468185	25.32574829	25.23392151	23.24254813	22.58403571	23.9199034	24.3014746	24.20954439
P00742	131	P00742;B7ZBK1;Q5JVE8	F10	Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2	11	11	140	coagulation;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	F10	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Extrinsic Pathway of Fibrin Clot Formation; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	-1.334808518	4.3e-07	6.15e-06	FDR <= 0.01	24.46674776	24.48323635	24.39765345	24.3493736	24.32107913	23.03006898	22.97149909	22.8646686	23.4629804	23.01483063
Q9NQ79	148	Q9NQ79-2;Q9NQ79;A0A0C4DFP6;Q9NQ79-3;Q5T4F6	CRTAC1	Cartilage acidic protein 1 OS=Homo sapiens OX=9606 GN=CRTAC1 PE=1 SV=2	9	9	58		extracellular	metal ion binding;protein binding	CRTAC1				-0.654732853	5.76e-05	0.000239066	FDR <= 0.01	21.52040517	21.48041903	21.5970327	21.5765211	21.76777604	20.91808062	20.80348708	21.12042645	20.85742654	20.96906909
A6PVI2	166	A6PVI2	PLG	Plasminogen (Fragment) OS=Homo sapiens OX=9606 GN=PLG PE=1 SV=1	9	1	170	cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;metabolic process;regulation of biological process;transport	cell surface;extracellular;membrane;organelle lumen	catalytic activity;protein binding	PLG	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; Complement and Coagulation Cascades			-0.65265687	0.00489571	0.010639088	FDR <= 0.05	17.47789597	17.48228484	17.29371237	17.29418667	16.83966107	16.15350643	16.72297442	16.6838342	17.07844353	16.48569799
Q16706	451	Q16706	MAN2A1	Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2	14	14	73	cell organization and biogenesis;metabolic process;regulation of biological process	Golgi;membrane	catalytic activity;metal ion binding	MAN2A1		Metabolic pathways; N-Glycan biosynthesis	Intra-Golgi traffic; Reactions specific to the complex N-glycan synthesis pathway	-0.350444916	0.003204355	0.007633576	FDR <= 0.01	20.55081288	20.51938048	20.44756702	20.43466239	20.45835334	20.24418509	20.06132236	20.24298345	20.1180267	19.99203393
P01005	191	P01005		Ovomucoid OS=Gallus gallus OX=9031 PE=1 SV=1	8	8	158	regulation of biological process;response to stimulus	endoplasmic reticulum;extracellular	enzyme regulator activity;protein binding	SPINK7; SPIK7				2.16803931	0.06144273	0.09470496	FDR > 0.05	20.55222766	26.60419001	26.39483976	26.39652585	26.37994256	27.66427138	27.95124897	27.07951805	27.12201925	27.35086474
P01019	477	P01019	AGT	Angiotensinogen OS=Homo sapiens OX=9606 GN=AGT PE=1 SV=1	10	10	192	cell communication;cell growth;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular	enzyme regulator activity;protein binding	AGT	Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Adipogenesis; IL-6 signaling pathway; ACE Inhibitor Pathway; Monoamine Transport	Renin secretion; Renin-angiotensin system	Peptide ligand-binding receptors; Metabolism of Angiotensinogen to Angiotensins; Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events; PPARA activates gene expression	-1.627519032	2.83e-07	4.71e-06	FDR <= 0.01	24.22463692	24.2462011	24.2206244	24.2505341	24.14486376	22.61219726	22.63967634	22.28086546	23.05680208	22.35972398
Q14520	587	Q14520-2;Q14520	HABP2	Hyaluronan-binding protein 2 OS=Homo sapiens OX=9606 GN=HABP2 PE=1 SV=1	11	11	139	metabolic process	extracellular	catalytic activity;metal ion binding	HABP2				-1.0450953	1.92e-05	9.72e-05	FDR <= 0.01	23.46521034	23.50793269	23.38338355	23.42161804	23.27255872	22.01219789	22.57420029	22.15780413	22.73215806	22.34886647
A0A4W8ZXM2	117	A0A4W8ZXM2;A0A0B4J1Y9	IGHV3-72	Immunoglobulin heavy variable 3-72 OS=Homo sapiens OX=9606 GN=IGHV3-72 PE=1 SV=1	6	4	337								0.50976451	0.022031805	0.038602735	FDR <= 0.05	24.11768543	24.23858623	24.20450939	24.17726275	24.10259502	25.36827276	24.74457184	24.65718559	24.19366042	24.42577077
H7C0N0	563	H7C0N0	ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1 (Fragment) OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=1	8	1	191	metabolic process;regulation of biological process		enzyme regulator activity					-1.811309696	0.001487709	0.003812255	FDR <= 0.01	16.70550464	16.86122122	16.90203595	16.79644214	17.04364765	14.20550936	16.8629225	14.53411542	15.16311515	14.48664069
Q7Z794	64	Q7Z794	KRT77	Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3	14	8	128	cell death;cell organization and biogenesis	cytoskeleton;cytosol	structural molecule activity	KRT77			Formation of the cornified envelope	0.492965479	0.088469639	0.128104446	FDR > 0.05	20.4867318	21.09674192	20.38735505	20.47805248	20.261521	20.40310094	21.41664694	21.09594514	21.7134284	20.54610824
G3V2W1	208	G3V2W1;Q9UK55	SERPINA10	Protein Z-dependent protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA10 PE=1 SV=1	10	10	103	coagulation;metabolic process;regulation of biological process	organelle lumen	enzyme regulator activity	SERPINA10				-1.309692724	6.34e-07	7.65e-06	FDR <= 0.01	22.73532266	22.82864945	22.74340141	22.79676991	22.86393092	21.46865217	21.57516405	21.26275322	21.84612651	21.2669148
P00748	520	P00748	F12	Coagulation factor XII OS=Homo sapiens OX=9606 GN=F12 PE=1 SV=3	12	12	143	coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;metal ion binding;protein binding;transporter activity	F12	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Intrinsic Pathway of Fibrin Clot Formation	-0.777334686	4.75e-06	3.14e-05	FDR <= 0.01	22.12167641	22.09632725	22.03916138	22.05201319	22.01555591	21.22540768	21.46277504	21.21141803	21.32856262	21.20989733
P22792	50	P22792	CPN2	Carboxypeptidase N subunit 2 OS=Homo sapiens OX=9606 GN=CPN2 PE=1 SV=3	10	10	119	metabolic process;regulation of biological process	extracellular	catalytic activity;enzyme regulator activity;protein binding	CPN2			Regulation of Complement cascade	-1.875531501	3.26e-06	2.42e-05	FDR <= 0.01	24.91250237	25.0724633	24.87521859	24.97519621	24.81697483	22.93833119	23.34890788	22.48772296	23.7468647	22.75287106
P08185	461	P08185;G3V350;G3V4V7	SERPINA6	Corticosteroid-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA6 PE=1 SV=1	8	8	111	metabolic process;regulation of biological process;transport	extracellular	enzyme regulator activity	SERPINA6				-1.535541076	9.02e-05	0.000344538	FDR <= 0.01	24.3467378	24.55003332	24.48405936	24.48277166	24.48500153	22.65791588	22.90186656	22.44226865	23.98725752	22.68158969
P22891	596	P22891-2;P22891	PROZ	Vitamin K-dependent protein Z OS=Homo sapiens OX=9606 GN=PROZ PE=1 SV=2	10	10	123	coagulation;metabolic process;regulation of biological process;transport	extracellular;organelle lumen	catalytic activity;metal ion binding;protein binding	PROZ			Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	-1.816833972	2.58e-07	4.58e-06	FDR <= 0.01	23.12532405	23.08446868	23.04199257	23.09671253	22.97020085	21.12590066	21.18447484	21.05884741	21.85724745	21.00805847
P21333	213	P21333-2;P21333;Q60FE5;F8WE98;A0A7I2V3E6;A0A087WWY3	FLNA	Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4	13	13	50	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus	protein binding;RNA binding;signal transducer activity	FLNA	Androgen receptor signaling pathway; Prolactin Signaling Pathway; Focal Adhesion; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; MAPK Signaling Pathway; IL-4 Signaling Pathway	Proteoglycans in cancer; MAPK signaling pathway; Salmonella infection; Focal adhesion	Platelet degranulation ; RHO GTPases activate PAKs; Cell-extracellular matrix interactions; GP1b-IX-V activation signalling	0.817565735	2.39e-05	0.000112405	FDR <= 0.01	19.49232272	19.5911541	19.58264393	19.54148384	19.64402256	20.3601711	20.31348429	20.10058041	20.52679431	20.6384257
Q96IY4	92	A0A087WSY5;Q96IY4;Q96IY4-2;A0A6Q8PG06;A0A6Q8PHS9	CPB2	Carboxypeptidase B2 OS=Homo sapiens OX=9606 GN=CPB2 PE=1 SV=2	11	11	126	cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding	CPB2	Complement and Coagulation Cascades	Complement and coagulation cascades; Protein digestion and absorption; Pancreatic secretion	Metabolism of Angiotensinogen to Angiotensins; Regulation of Complement cascade	-1.759909784	1.96e-05	9.78e-05	FDR <= 0.01	24.38925334	24.44091858	24.38154819	24.37912242	24.12052482	22.33093904	23.10727434	22.15875643	23.28778597	22.02706264
M0R1Q1	452	M0R1Q1	C3	Complement C3 (Fragment) OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=1	7	1	187	metabolic process;regulation of biological process;response to stimulus		enzyme regulator activity		Allograft Rejection; TYROBP Causal Network			2.244323789	1.43e-05	7.66e-05	FDR <= 0.01	16.14509355	16.13076295	15.68350716	15.64928295	16.42904067	17.95329066	19.40851247	17.84891967	18.19087124	17.85771216
O00533	349	O00533;A0A087X0M8;O00533-2;C9J905;C9JH37;C9JW79;H7C0J0	CHL1	Neural cell adhesion molecule L1-like protein OS=Homo sapiens OX=9606 GN=CHL1 PE=1 SV=4	13	13	48	cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	CHL1			CHL1 interactions	-1.378100377	7.13e-07	8.04e-06	FDR <= 0.01	21.00072008	21.08013357	20.98864627	20.9064463	20.88251436	19.75816972	19.56581976	19.24382044	19.92982798	19.47032079
P20023-3	222	P20023-3;P20023-4	CR2	Isoform C of Complement receptor type 2 OS=Homo sapiens OX=9606 GN=CR2	7	1	25	cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus	membrane	DNA binding;protein binding;receptor activity;signal transducer activity	CR2	B Cell Receptor Signaling Pathway; Oxidative Damage; Complement and Coagulation Cascades			0.442152084	0.021357392	0.037635518	FDR <= 0.05	19.39063526	19.35345909	19.29865036	19.39165932	19.35735309	19.94269767	20.37264295	19.64348814	19.44352188	19.60016691
P04196	462	P04196	HRG	Histidine-rich glycoprotein OS=Homo sapiens OX=9606 GN=HRG PE=1 SV=1	11	11	113	coagulation;defense response;regulation of biological process;response to stimulus;transport	cell surface;endosome;extracellular;membrane;organelle lumen;vacuole	enzyme regulator activity;metal ion binding;protein binding	HRG			Platelet degranulation ; Dissolution of Fibrin Clot	-0.669768734	0.007355049	0.015281605	FDR <= 0.05	23.55390072	23.59782161	23.41967897	23.43407646	23.47681976	23.39910977	22.84519344	22.25567674	23.16638046	22.46709343
A0A087X0S5	377	A0A087X0S5;P12109	COL6A1	Collagen alpha-1(VI) chain OS=Homo sapiens OX=9606 GN=COL6A1 PE=1 SV=1	11	11	66					miRNA targets in ECM and membrane receptors			0.321881607	0.020667006	0.036841184	FDR <= 0.05	20.13110506	20.06370252	20.01231654	20.19339974	20.09572946	20.1109726	20.68661041	20.52543689	20.45141698	20.33122447
Q14766	436	E7EV71;Q14766;Q14766-5;Q14766-4;Q14766-2;C9JD84;Q14766-3;H7C2H7;H7C4L5	LTBP1	Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4	10	10	38	metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	LTBP1	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-beta Receptor Signaling	TGF-beta signaling pathway	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Molecules associated with elastic fibres	2.379778244	4.65e-08	2.44e-06	FDR <= 0.01	18.89066054	18.78830857	18.63288637	18.6496631	18.78426367	20.90720839	21.09987917	21.38333358	20.6363794	21.61787293
A0A5H1ZRS9	145	A0A5H1ZRS9;A0A075B6S2;A2NJV5	IGKV2D-29	Immunoglobulin kappa variable 2D-29 OS=Homo sapiens OX=9606 GN=IGKV2D-29 PE=1 SV=1	3	2	252								-0.267531922	0.405132719	0.478227682	FDR > 0.05	22.56728097	22.55316164	22.47386771	22.51081106	22.36954806	23.4642488	22.32227441	21.46591899	22.10457092	21.77999671
P06276	539	P06276;F8WF14;F8WEX7;H0Y885;H7C4Y0	BCHE	Cholinesterase OS=Homo sapiens OX=9606 GN=BCHE PE=1 SV=1	11	11	88	cell differentiation;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;extracellular;membrane;organelle lumen	catalytic activity;protein binding	BCHE	Irinotecan Pathway		Synthesis of PC; Synthesis, secretion, and deacylation of Ghrelin; Neurotransmitter clearance	-1.115475135	1.43e-06	1.29e-05	FDR <= 0.01	22.2139749	22.36379951	22.22184041	22.27099616	22.15749138	21.28444595	21.07724212	20.97263867	21.3947354	20.92166455
P05154	510	P05154;G3V2M1;G3V264;G3V265;G3V482	SERPINA5	Plasma serine protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA5 PE=1 SV=3	12	12	88	cell organization and biogenesis;coagulation;regulation of biological process;transport	extracellular;membrane	enzyme regulator activity;protein binding	SERPINA5	Complement and Coagulation Cascades	Complement and coagulation cascades	Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation	0.26966838	0.188978912	0.241124545	FDR > 0.05	22.02664019	22.03724409	22.04171011	21.94269636	21.93964386	22.42977404	22.92802021	21.92319479	22.25655867	21.79872879
A0A0A0MS15	616	A0A0A0MS15	IGHV3-49	Immunoglobulin heavy variable 3-49 OS=Homo sapiens OX=9606 GN=IGHV3-49 PE=3 SV=1	5	4	129	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-49				-0.241803645	0.108145417	0.149124286	FDR > 0.05	23.60317498	23.61999225	23.52097539	23.57359135	23.5103829	23.29465703	23.46816508	23.72779658	23.00303344	23.1254465
P00740	331	P00740;P00740-2	F9	Coagulation factor IX OS=Homo sapiens OX=9606 GN=F9 PE=1 SV=2	9	9	77	coagulation;metabolic process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	F9	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Extrinsic Pathway of Fibrin Clot Formation; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	-1.08795795	5.53e-06	3.58e-05	FDR <= 0.01	22.90294355	22.99161782	22.91102541	22.90777435	22.97349429	21.86131839	22.16520713	21.52172329	22.035715	21.66310188
P68871	292	P68871;A0A2R8Y7R2;F8W6P5;A0A0J9YWK4	HBB	Hemoglobin subunit beta OS=Homo sapiens OX=9606 GN=HBB PE=1 SV=2	8	4	168	cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;organelle lumen	antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity	HBB	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism	Malaria; African trypanosomiasis	Neutrophil degranulation; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Factors involved in megakaryocyte development and platelet production	3.038645087	8.06e-09	1.93e-06	FDR <= 0.01	22.48861517	22.45519017	22.34957614	22.52102697	22.33292235	25.73279573	25.8017194	25.35735199	24.76222234	25.68646678
P69905	22	P69905;A0A2R8Y7C0;G3V1N2	HBA1	Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2	8	5	106	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;membrane;organelle lumen	antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity	HBA2; HBA1	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Effects of Nitric Oxide	African trypanosomiasis; Malaria	Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide	2.504768032	4.7e-08	2.44e-06	FDR <= 0.01	21.05574059	21.15727217	21.07368197	21.03506648	21.0815387	23.72267593	24.00702801	23.47453909	22.90649048	23.81640656
Q92496	628	Q92496-2;Q92496;Q92496-3;A0A0C4DH21	CFHR4	Complement factor H-related protein 4 OS=Homo sapiens OX=9606 GN=CFHR4 PE=1 SV=3	7	3	46	regulation of biological process;transport	extracellular	transporter activity	CFHR4			Regulation of Complement cascade	0.162655462	0.297040888	0.363904674	FDR > 0.05	20.77116488	20.76719722	20.7589777	20.64273733	20.59261278	20.8733028	20.58308646	21.34833943	20.60076893	20.94046961
Q12805	408	Q12805-3;Q12805-4;Q12805-5;Q12805;Q12805-2;A0A0U1RQV3	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=EFEMP1 PE=1 SV=2	9	9	66	metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;membrane	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	EFEMP1			Molecules associated with elastic fibres	-0.410802699	0.073204506	0.109009131	FDR > 0.05	21.81390404	21.8903319	21.82526376	21.83669567	21.87690883	21.23928168	20.95284048	22.00507831	21.07300388	21.91888636
P11047	336	P11047	LAMC1	Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3	12	12	46	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process	extracellular;organelle lumen	catalytic activity;motor activity;protein binding;structural molecule activity	LAMC1	Alpha 6 Beta 4 signaling pathway; Endoderm Differentiation; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway	Toxoplasmosis; ECM-receptor interaction; Prion diseases; Focal adhesion; Pathways in cancer; Amoebiasis; PI3K-Akt signaling pathway; Small cell lung cancer	ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	0.898958451	2.22e-05	0.000106849	FDR <= 0.01	19.82006701	19.79859346	19.7529133	19.78210442	19.79011781	20.71288611	20.78249653	21.02022298	20.34891867	20.57406395
A0A096LPE2	348	A0A096LPE2;P35542	SAA2-SAA4	SAA2-SAA4 readthrough OS=Homo sapiens OX=9606 GN=SAA2-SAA4 PE=3 SV=1	10	6	157	cellular component movement;defense response;response to stimulus	extracellular		SAA2-SAA4				-0.655448919	0.020891336	0.037104033	FDR <= 0.05	25.25397386	25.08849117	24.97611218	25.10601884	24.76333319	24.39122071	23.47335883	24.9991031	24.47292806	24.57407393
P68133	533	P68032;P68133;P63267;P62736;A6NL76;C9JFL5;F6UVQ4	ACTA1	Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1	8	1	108	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol	nucleotide binding;protein binding;structural molecule activity	ACTA1	Myometrial Relaxation and Contraction Pathways; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Association Between Physico-Chemical Features and Toxicity Associated Pathways; Striated Muscle Contraction		Striated Muscle Contraction	0.144581691	0.717063185	0.753835656	FDR > 0.05	20.33250692	20.43766619	20.34177706	20.49626919	20.60056298	20.21491568	20.3225095	19.91268544	22.30560647	20.17597371
D6RD17	303	P01591;D6RD17;D6RHJ6	JCHAIN	Immunoglobulin J chain (Fragment) OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=8	6	6	366								1.246688502	0.000742026	0.002074301	FDR <= 0.01	27.00644226	27.10331868	26.98203769	27.08767759	26.93253813	29.18844081	28.64650493	28.13647748	27.76907628	27.60495735
P04075	5	P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78;H3BUH7;H3BMQ8;H3BR68	ALDOA	Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2	11	11	61	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;protein binding;RNA binding	ALDOA	Glycolysis and Gluconeogenesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	Pentose phosphate pathway; HIF-1 signaling pathway; Glycolysis / Gluconeogenesis; Carbon metabolism; Metabolic pathways; Biosynthesis of amino acids; Fructose and mannose metabolism	Platelet degranulation ; Gluconeogenesis; Glycolysis; Neutrophil degranulation	0.227958748	0.38978603	0.464570559	FDR > 0.05	21.28258061	21.28946411	21.20326475	21.39550267	21.24944319	21.04703939	21.29535173	21.35915324	22.59728129	21.26122342
Q9HDC9	570	Q9HDC9;H0Y512;Q9HDC9-2	APMAP	Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2	10	10	60	metabolic process	cell surface;endoplasmic reticulum;membrane	catalytic activity	APMAP				-1.583903524	3.66e-06	2.68e-05	FDR <= 0.01	22.58903446	22.60332675	22.5504543	22.54649271	22.46763795	20.93571783	20.6016346	20.52909384	21.48645674	21.28452555
A0A3B3IS80	360	P05062;A0A3B3IS80;A0A087WXX2;A0A3B3ITZ0	ALDOB	Fructose-bisphosphate aldolase OS=Homo sapiens OX=9606 GN=ALDOB PE=1 SV=1	9	9	56								-0.53389879	0.000428466	0.0012917	FDR <= 0.01	20.16761636	20.23992064	20.1207315	20.31373093	20.14442234	19.78304073	19.88088965	19.50535673	19.61833419	19.52930653
P20023	468	P20023;P20023-2;Q5SR47	CR2	Complement receptor type 2 OS=Homo sapiens OX=9606 GN=CR2 PE=1 SV=2	7	1	25	cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus	membrane	DNA binding;protein binding;receptor activity;signal transducer activity	CR2	B Cell Receptor Signaling Pathway; Oxidative Damage; Complement and Coagulation Cascades	Epstein-Barr virus infection; B cell receptor signaling pathway; Hematopoietic cell lineage; Complement and coagulation cascades	Regulation of Complement cascade	0.116314435	0.618836486	0.670043027	FDR > 0.05	13.81640147	13.76256922	13.68050917	13.86173844	13.94680141	13.53070443	14.7442511	13.85715104	13.38948889	14.12799643
P01742	17	P01742;A0A0B4J2H0	IGHV1-69	Immunoglobulin heavy variable 1-69 OS=Homo sapiens OX=9606 GN=IGHV1-69 PE=1 SV=2	6	5	100	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV1-69			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.400058602	0.107328353	0.148330196	FDR > 0.05	24.0644638	24.27444202	23.82085824	23.95772017	23.76190312	23.38503102	22.90224896	24.16384583	23.42783816	24.00013036
P07355	420	P07355;H0YMW4;P07355-2;H0YN42;H0YMD0;H0YMU9;A6NMY6;H0YM50;H0YL33;H0YNB8;H0YKS4;H0YN28;H0YNP5;H0YMM1;A0A7I2V4P4;H0YMT9;H0YLV6;H0YKZ7;H0YKX9;H0YKL9;H0YKV8;H0YNA0;H0YMD9	ANXA2	Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2	13	13	77	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;membrane;nucleus;organelle lumen	enzyme regulator activity;metal ion binding;protein binding;RNA binding	ANXA2	Prostaglandin Synthesis and Regulation		Dissolution of Fibrin Clot; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Neutrophil degranulation; Interleukin-12 family signaling	0.808665295	0.015027446	0.028090818	FDR <= 0.05	21.31095164	21.14411722	20.97136412	21.45106698	20.88545287	21.49131325	22.10338009	21.87152532	22.99016339	21.34989724
Q99784	586	Q99784;Q99784-3;Q99784-5;F5H810;F8W870;F5GZQ2;Q99784-2;Q99784-4	OLFM1	Noelin OS=Homo sapiens OX=9606 GN=OLFM1 PE=1 SV=4	7	7	100	cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;extracellular	metal ion binding;protein binding	OLFM1				0.875412632	0.001319381	0.003452847	FDR <= 0.01	22.29378238	22.31296355	22.30473325	22.28075684	22.22467964	23.40869923	23.83996008	23.00823236	22.59026993	22.94681721
P10586	722	P10586-2;P10586;H0Y6Z7;H0Y7Z9;H0Y4H1	PTPRF	Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2	10	10	43	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	membrane	catalytic activity;protein binding;receptor activity;signal transducer activity	PTPRF	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Insulin Signaling	Adherens junction; Insulin signaling pathway; Insulin resistance; Cell adhesion molecules (CAMs)	Receptor-type tyrosine-protein phosphatases; Synaptic adhesion-like molecules	0.122085329	0.52962229	0.591139217	FDR > 0.05	19.86010101	19.94473426	19.85237795	19.88287775	19.88766768	19.71869796	20.76916463	19.96010298	19.73256812	19.85765161
Q13093	367	Q13093	PLA2G7	Platelet-activating factor acetylhydrolase OS=Homo sapiens OX=9606 GN=PLA2G7 PE=1 SV=1	8	8	50	cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;extracellular	catalytic activity	PLA2G7	IL1 and megakaryocytes in obesity	Ether lipid metabolism; Metabolic pathways	Synthesis, secretion, and deacylation of Ghrelin	0.653842391	0.020189966	0.036095433	FDR <= 0.05	21.08111506	21.12459749	20.99565076	21.07651608	20.97132233	21.96058721	20.8058136	21.87324776	21.53509303	22.34367208
P43251	356	P43251-4;P43251;P43251-3;P43251-2;A0A5F9ZH15;A0A5F9ZH80;C9JSN9;A0A5F9ZHE9;A0A2R8Y5J9;A0A5F9ZHR1;A0A5F9ZH97;A0A5F9ZHF5;A0A5F9ZH57	BTD	Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2	7	7	111	metabolic process	extracellular;organelle lumen	catalytic activity	BTD		Metabolic pathways; Vitamin digestion and absorption; Biotin metabolism	Defective BTD causes biotidinase deficiency; Biotin transport and metabolism	-2.169794171	3.77e-07	5.52e-06	FDR <= 0.01	23.83432859	23.84986801	23.81614876	23.73584669	23.67657185	21.36471007	21.46400395	21.295496	22.41508114	21.52450188
V9GYM3	339	V9GYM3;V9GYG9;P02652;V9GYE3;V9GYS1;V9GYC1	APOA2	Apolipoprotein A-II OS=Homo sapiens OX=9606 GN=APOA2 PE=1 SV=1	7	7	108	metabolic process;transport	extracellular			PPAR Alpha Pathway; PPAR signaling pathway			-0.1421113	0.663148219	0.70804888	FDR > 0.05	25.08132971	24.93813961	24.67375206	25.03295338	24.66287574	24.76825699	23.45198613	25.49299919	25.00059495	24.96465674
P11226	273	P11226	MBL2	Mannose-binding protein C OS=Homo sapiens OX=9606 GN=MBL2 PE=1 SV=2	9	9	78	defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular	catalytic activity;metal ion binding;protein binding	MBL2	Regulation of toll-like receptor signaling pathway	Phagosome; Staphylococcus aureus infection; Complement and coagulation cascades	Lectin pathway of complement activation	0.464837294	0.067929066	0.102644657	FDR > 0.05	23.40452854	23.44474998	23.35220001	23.44143157	23.30195612	23.72635101	23.38591478	24.80345779	23.62217026	23.73115885
P33908	459	P33908;P33908-2	MAN1A1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Homo sapiens OX=9606 GN=MAN1A1 PE=1 SV=3	9	9	46	metabolic process	cytosol;endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding	MAN1A1		Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2; Intra-Golgi traffic	-0.403858452	0.000556074	0.001605567	FDR <= 0.01	21.13039573	21.23985108	21.15337399	21.1495711	21.22822786	20.79905193	20.72531348	20.82348038	20.77744819	20.75683353
C9JVG0	220	C9JVG0	TF	Serotransferrin (Fragment) OS=Homo sapiens OX=9606 GN=TF PE=1 SV=1	7	1	122		extracellular			Iron metabolism in placenta; Differentiation Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways			0.723740238	0.000795998	0.002205129	FDR <= 0.01	17.50666416	17.21782674	17.07843351	17.3059038	17.42302501	18.29226325	17.70721145	18.13424835	17.70706941	18.30976193
P19652	604	P19652	ORM2	Alpha-1-acid glycoprotein 2 OS=Homo sapiens OX=9606 GN=ORM2 PE=1 SV=2	8	6	137	defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen		ORM2			Platelet degranulation ; Neutrophil degranulation	-0.773762822	0.000381674	0.001197601	FDR <= 0.01	25.34869068	25.31026361	25.10628232	25.25369569	25.12996198	24.81550129	24.5421443	24.00972237	24.62912806	24.28358413
P02743	204	P02743	APCS	Serum amyloid P-component OS=Homo sapiens OX=9606 GN=APCS PE=1 SV=2	8	8	161	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;nucleus	metal ion binding;protein binding	APCS			Amyloid fiber formation	-0.550446441	0.00950375	0.018976643	FDR <= 0.05	25.82982151	25.82084733	25.70185971	25.79081441	25.55064321	25.23953336	24.76383927	25.69121049	24.85882587	25.38834497
Q96PD5	30	Q96PD5;Q96PD5-2	PGLYRP2	N-acetylmuramoyl-L-alanine amidase OS=Homo sapiens OX=9606 GN=PGLYRP2 PE=1 SV=1	6	6	85	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;metal ion binding;receptor activity;signal transducer activity	PGLYRP2			Antimicrobial peptides	-0.966743268	5.79e-05	0.000239066	FDR <= 0.01	23.33191329	23.29065347	23.25538939	23.36071196	23.17403474	22.31083356	22.68559432	21.87515847	22.5517709	22.15562925
P55058	103	P55058;P55058-4;P55058-2;P55058-3	PLTP	Phospholipid transfer protein OS=Homo sapiens OX=9606 GN=PLTP PE=1 SV=1	7	7	61	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	extracellular	transporter activity	PLTP	PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway	PPAR signaling pathway	HDL remodeling	-0.194409952	0.240131023	0.301388938	FDR > 0.05	20.87097209	20.932712	20.85324903	20.98298638	20.78835293	21.15053612	20.36713704	20.94644446	20.48156277	20.51054228
J3KQ66	401	J3KQ66;P78509;P78509-3;P78509-2	RELN	Reelin OS=Homo sapiens OX=9606 GN=RELN PE=1 SV=1	10	10	60	cellular component movement		protein binding		Focal Adhesion-PI3K-Akt-mTOR-signaling pathway			0.671311456	0.000775769	0.002158815	FDR <= 0.01	20.28038619	20.42279234	20.40212005	20.48918616	20.52086057	21.41728229	21.38356969	20.99765193	20.73454142	20.93885726
P18428	243	P18428	LBP	Lipopolysaccharide-binding protein OS=Homo sapiens OX=9606 GN=LBP PE=1 SV=3	5	5	72	cellular component movement;defense response;regulation of biological process;response to stimulus;transport	cell surface;extracellular;membrane	protein binding	LBP	Regulation of toll-like receptor signaling pathway; Toll-like receptor signaling pathway	Salmonella infection; NF-kappa B signaling pathway; Toll-like receptor signaling pathway; Tuberculosis	Transfer of LPS from LBP carrier to CD14; Interleukin-4 and 13 signaling; Regulation of TLR by endogenous ligand	-0.484653013	0.01834098	0.03327346	FDR <= 0.05	21.46302388	21.6306418	21.51935558	21.62953938	21.51801895	20.91204042	21.53523028	20.64092269	21.42707698	20.82204416
Q4LDE5	109	A0A0A0MSD0;Q4LDE5;Q4LDE5-4;Q4LDE5-2;Q4LDE5-3	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3	11	11	46		cell surface;cytoplasm;extracellular;membrane	metal ion binding;protein binding	SVEP1				0.49689933	0.00838751	0.017110551	FDR <= 0.05	19.73518131	19.85875487	19.78683953	19.85617333	19.83550615	20.3339641	20.04954653	20.81010691	19.96010859	20.40322571
A0A0C4DH31	728	A0A0C4DH31	IGHV1-18	Immunoglobulin heavy variable 1-18 OS=Homo sapiens OX=9606 GN=IGHV1-18 PE=3 SV=1	4	2	70	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV1-18				0.342352206	0.104360003	0.145206792	FDR > 0.05	20.70767018	20.67181093	20.66513542	20.7326271	20.6378495	21.13585816	20.81533982	21.744277	20.56092582	20.87045336
P01743	490	P01743	IGHV1-46	Immunoglobulin heavy variable 1-46 OS=Homo sapiens OX=9606 GN=IGHV1-46 PE=1 SV=2	5	3	61	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV1-46			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.004208251	0.979687303	0.986100968	FDR > 0.05	20.96475461	21.00430388	21.15117345	21.05714938	20.99666825	21.32763318	20.75070392	21.43741663	20.61817364	21.06116345
P02750	260	P02750	LRG1	Leucine-rich alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=LRG1 PE=1 SV=2	8	8	134	cell differentiation;regulation of biological process;transport	extracellular;membrane;organelle lumen	protein binding	LRG1			Neutrophil degranulation	-3.190842927	2.13e-06	1.73e-05	FDR <= 0.01	26.1009778	26.07584549	26.03199591	26.04926943	25.97514091	22.88154243	22.41191647	21.95531134	24.26190348	22.76834119
P04070	422	P04070-2;P04070;E7END6;H7BYX9;E7ENR9	PROC	Vitamin K-dependent protein C OS=Homo sapiens OX=9606 GN=PROC PE=1 SV=1	8	8	60	cellular component movement;coagulation;metabolic process;regulation of biological process;transport	endoplasmic reticulum;extracellular;Golgi;organelle lumen	catalytic activity;metal ion binding;protein binding	PROC	Complement and Coagulation Cascades	Complement and coagulation cascades	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	-1.059042337	0.000351814	0.001126905	FDR <= 0.01	22.13185924	22.18577542	22.08955083	22.16999911	22.02489522	20.83132099	20.34043627	21.28344766	21.27443569	21.57722753
P07942	192	P07942;G3XAI2;A0A7I2V4J9;A0A7I2V5X5;A0A7I2V3I5;A0A7I2V2T9;A0A7I2V3J7;A0A7I2V407;A0A7I2V682;A0A7I2V5R0;A0A7I2V2R2;A0A7I2V2J0;E7EPA6;C9J296;A0A7I2V5T9	LAMB1	Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2	9	9	43	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;motor activity;nucleotide binding;protein binding;signal transducer activity;structural molecule activity	LAMB1	Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway	Toxoplasmosis; ECM-receptor interaction; Amoebiasis; Focal adhesion; Pathways in cancer; PI3K-Akt signaling pathway; Small cell lung cancer	ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	0.669089149	0.000236023	0.000793515	FDR <= 0.01	19.77186125	19.80714273	19.79678313	19.82156209	19.66168151	20.37388747	20.38868697	20.76269165	20.12955469	20.54965569
P0DJI8	346	P0DJI8;E9PQD6;P0DJI9	SAA1	Serum amyloid A-1 protein OS=Homo sapiens OX=9606 GN=SAA1 PE=1 SV=1	8	4	53	cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	SAA1	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism		Amyloid fiber formation; TRAF6 mediated NF-kB activation; G alpha (i) signalling events; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Formyl peptide receptors bind formyl peptides and many other ligands; Activated TLR4 signalling; Interleukin-1 family signaling; Scavenging by Class B Receptors; Gastrin-CREB signalling pathway via PKC and MAPK; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Interleukin-4 and 13 signaling	-0.06778418	0.579612904	0.636539171	FDR > 0.05	20.26691051	20.09910166	20.12858696	20.13363044	19.92004731	20.18233277	19.73391217	20.14535224	19.98192897	20.16582984
P06331	53	P06331	IGHV4-34	Immunoglobulin heavy variable 4-34 OS=Homo sapiens OX=9606 GN=IGHV4-34 PE=1 SV=2	4	1	210	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	LOC100289944; IGHV4-34			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.418768931	0.122215682	0.164925118	FDR > 0.05	20.06923978	20.10678461	19.9895298	20.04527405	19.91930538	20.91913272	19.86900059	21.22991849	19.93873841	20.26718806
P01817	275	P01817	IGHV2-5	Immunoglobulin heavy variable 2-5 OS=Homo sapiens OX=9606 GN=IGHV2-5 PE=1 SV=2	2	2	23	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV2-5			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.476788119	0.014272792	0.027091873	FDR <= 0.05	18.96644295	19.03389594	18.98264774	19.1765727	19.13484129	19.94771502	19.73323658	19.5968239	19.02020236	19.38036335
P01764	703	P01764	IGHV3-23	Immunoglobulin heavy variable 3-23 OS=Homo sapiens OX=9606 GN=IGHV3-23 PE=1 SV=2	5	2	107	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;protein binding	IGHV3-23			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.689070359	0.010848246	0.021591169	FDR <= 0.05	20.16900956	20.24674655	20.23966388	20.34798375	20.30801612	21.77910934	20.72001453	21.1484244	20.40076905	20.70845433
K7ER74	284	K7ER74;P02655;V9GYJ8;Q6P163	APOC4-APOC2	Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC4-APOC2 PE=1 SV=1	7	5	97	metabolic process;regulation of biological process;transport		enzyme regulator activity					0.704803213	0.027664345	0.047259923	FDR <= 0.05	23.06123071	22.95395967	22.81523106	22.87893871	22.67237736	23.37222152	22.67426932	24.11981931	23.39498685	24.34445656
P08709	184	F5H8B0;P08709;P08709-2	F7	Coagulation factor VII OS=Homo sapiens OX=9606 GN=F7 PE=1 SV=1	7	7	35	coagulation;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	F7	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Extrinsic Pathway of Fibrin Clot Formation; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors	-0.838400073	0.00238624	0.005846763	FDR <= 0.01	18.95612357	19.34524097	19.26305244	19.34136618	19.32520409	18.26635798	17.86981997	18.12328033	18.72210226	19.05742634
Q14515	62	Q14515;Q14515-2	SPARCL1	SPARC-like protein 1 OS=Homo sapiens OX=9606 GN=SPARCL1 PE=1 SV=2	9	9	34	metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	metal ion binding;protein binding	SPARCL1			Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.139257988	0.289548629	0.356144814	FDR > 0.05	19.03306442	19.10525631	19.04846087	19.11869214	19.06220632	19.2263763	19.3221613	19.4604919	18.80497948	19.24996103
K7EMS3	152	K7EMS3	KRT19	Keratin, type I cytoskeletal 19 (Fragment) OS=Homo sapiens OX=9606 GN=KRT19 PE=1 SV=1	7	1	47			structural molecule activity					0.401045533	0.023500898	0.040827832	FDR <= 0.05	17.00747263	17.03632784	16.72623983	17.27247367	16.81075257	17.211392	17.81082735	17.33453713	17.17238942	17.3293483
P04180	526	P04180;J3QKT0;J3QSE5	LCAT	Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1	6	6	46	cell organization and biogenesis;metabolic process;regulation of biological process;transport	extracellular	catalytic activity;protein binding	LCAT	Composition of Lipid Particles; Statin Pathway	Glycerophospholipid metabolism	HDL remodeling	-1.329008625	1.23e-06	1.15e-05	FDR <= 0.01	22.7650745	22.75349339	22.58821784	22.71585773	22.57155277	21.13937699	21.11118569	21.2366537	21.72257936	21.53935737
P05109	229	P05109	S100A8	Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1	9	9	75	cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	metal ion binding;protein binding	S100A8			Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand	1.224317357	0.00114955	0.00303422	FDR <= 0.01	21.1977241	21.67811458	21.57259253	22.1378889	21.59868548	22.22031153	22.96186004	23.11314955	23.67842403	22.33284722
A0A5H1ZRS2	316	A0A5H1ZRS2	IGKV2D-28	Immunoglobulin kappa variable 2D-28 OS=Homo sapiens OX=9606 GN=IGKV2D-28 PE=1 SV=1	4	2	264								0.148979404	0.488221732	0.554816226	FDR > 0.05	25.59141693	25.5161991	25.37064305	25.48354058	25.25913332	26.23304474	25.90095583	25.53724429	25.17612617	25.11845898
P02763	578	P02763	ORM1	Alpha-1-acid glycoprotein 1 OS=Homo sapiens OX=9606 GN=ORM1 PE=1 SV=1	7	5	132	defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	ORM1			Platelet degranulation ; Neutrophil degranulation	1.12189183	2.5e-05	0.000115561	FDR <= 0.01	24.45084065	24.47493327	24.39531218	24.41828719	24.39896918	25.70846502	25.41346359	25.48189712	25.09960837	26.04436752
A0A087WX77	71	A0A087WX77;P13591;H7BYX6;P13591-3;A0A087WWD4;A0A087WTE4;A0A087WV75;P13591-1;A0A087WTF6;P13591-4;P13591-5;A0A087X1V2;A0A087WVU1;A0A0D9SF98;A0A087WWJ5;A0A0C4DGS4;P13591-6	NCAM1	Neural cell adhesion molecule 1 OS=Homo sapiens OX=9606 GN=NCAM1 PE=1 SV=1	9	9	49		cytosol;membrane	protein binding		Cardiac Progenitor Differentiation			-0.915121759	2e-05	9.9e-05	FDR <= 0.01	21.13058377	21.18123582	21.08909119	21.1413591	20.97722475	20.58931538	20.03547116	20.02716242	20.23830083	20.05363605
P11597	414	P11597;P11597-2;H3BRJ9	CETP	Cholesteryl ester transfer protein OS=Homo sapiens OX=9606 GN=CETP PE=1 SV=2	8	8	48	cell organization and biogenesis;metabolic process;regulation of biological process;transport	extracellular	transporter activity	CETP	Composition of Lipid Particles; Statin Pathway		LDL remodeling; HDL remodeling	0.355187411	0.03547984	0.058973248	FDR > 0.05	18.7765971	18.93398665	18.83368216	18.88024195	18.9801632	19.36076398	18.75208388	19.38036841	19.1313037	19.55608814
P31944	14	P31944	CASP14	Caspase-14 OS=Homo sapiens OX=9606 GN=CASP14 PE=1 SV=2	8	8	55	cell death;cell differentiation;metabolic process	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	CASP14			Formation of the cornified envelope	0.49512109	0.091551932	0.13186051	FDR > 0.05	20.05260858	20.56745222	21.10556225	20.35381953	20.22301236	20.59078374	21.70577284	20.88518351	21.19219103	20.40412926
P14618	646	P14618;P14618-3;B4DNK4	PKM	Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4	10	1	54	cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport	cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding	PKM	Photodynamic therapy-induced HIF-1 survival signaling; Amino Acid metabolism; Glycolysis and Gluconeogenesis	Carbon metabolism; Metabolic pathways; Glucagon signaling pathway; Purine metabolism; Viral carcinogenesis; Biosynthesis of amino acids; Type II diabetes mellitus; Glycolysis / Gluconeogenesis; Pyruvate metabolism; Central carbon metabolism in cancer	Glycolysis; Neutrophil degranulation	-0.0505398	0.837159911	0.862400914	FDR > 0.05	20.08393449	19.87207736	19.78629893	19.97506782	19.83645252	19.58015584	19.67521805	19.66791794	20.87362492	19.50421537
E9PKE3	121	E9PKE3;P11142;P11142-2;E9PN89;P54652;A8K7Q2;E9PNE6;E9PS65;E9PM13;P17066	HSPA8	Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1	9	5	46	cell organization and biogenesis		nucleotide binding					0.4240148	0.101288312	0.143530672	FDR > 0.05	20.79885942	20.87784238	20.78952284	21.09635305	20.72119749	21.11505062	21.76621747	21.06107753	21.90674314	20.55476043
P14625	54	P14625;Q96GW1;A0A1W2PRR1;Q58FF3;H0YIV0	HSP90B1	Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1	11	11	48	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen	metal ion binding;nucleotide binding;protein binding;RNA binding	HSP90B1	Photodynamic therapy-induced unfolded protein response; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	Thyroid hormone synthesis; Pathways in cancer; Estrogen signaling pathway; Prostate cancer; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors	-0.607048694	0.000468471	0.001379655	FDR <= 0.01	21.13443309	21.16711879	21.09244959	21.19860306	21.05813358	20.34432083	20.65827988	20.33091079	20.86510906	20.41687407
H7C0V9	68	P05067-11;P05067-9;P05067;H7C0V9;P05067-7;E9PG40;P05067-8;P05067-4;P05067-10;P05067-3;P05067-5;P05067-6;A0A0A0MRG2;P05067-2;H7C2L2	APP	Amyloid-beta A4 protein (Fragment) OS=Homo sapiens OX=9606 GN=APP PE=1 SV=1	6	6	34	regulation of biological process		enzyme regulator activity;metal ion binding;protein binding		Alzheimers Disease; Endoderm Differentiation; Copper homeostasis			1.937993025	9.98e-06	5.69e-05	FDR <= 0.01	18.2886909	18.46932901	18.34469009	18.45976325	18.21507419	20.21890596	20.03559352	20.53413443	19.54049747	21.13838118
P19320	110	P19320;P19320-2;E9PDD2;P19320-3	VCAM1	Vascular cell adhesion protein 1 OS=Homo sapiens OX=9606 GN=VCAM1 PE=1 SV=1	7	7	27	cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;endosome;Golgi;membrane	catalytic activity;protein binding	VCAM1	RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Photodynamic therapy-induced NF-kB survival signaling; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits	TNF signaling pathway; African trypanosomiasis; AGE-RAGE signaling pathway in diabetic complications; Malaria; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; HTLV-I infection; NF-kappa B signaling pathway	Integrin cell surface interactions; Interleukin-4 and 13 signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling	1.474821019	1.66e-05	8.66e-05	FDR <= 0.01	20.93510468	21.03544089	20.9024476	20.87382627	20.79828016	22.50668911	23.13970262	22.08255267	22.17264327	22.017617
Q15113	300	Q15113	PCOLCE	Procollagen C-endopeptidase enhancer 1 OS=Homo sapiens OX=9606 GN=PCOLCE PE=1 SV=2	7	7	45	development;metabolic process;regulation of biological process	extracellular	enzyme regulator activity;protein binding	PCOLCE			Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	-0.253952106	0.120218026	0.16285041	FDR > 0.05	21.47020884	21.41380274	21.39845375	21.39569685	21.24969145	21.62535516	21.20753008	20.92837477	21.10218554	20.79464754
P0DP08	656	P0DP08	IGHV4-38-2	Immunoglobulin heavy variable 4-38-2 OS=Homo sapiens OX=9606 GN=IGHV4-38-2 PE=3 SV=1	4	1	201	response to stimulus	extracellular;membrane		IGHV4-B; IGHV4-38-2				0.096180229	0.484482083	0.553534533	FDR > 0.05	18.05885165	17.98418256	17.98767364	18.05767047	18.27681377	18.13150724	18.01062796	18.52942391	17.89566009	18.27887403
P08571	580	P08571;D6RFL4	CD14	Monocyte differentiation antigen CD14 OS=Homo sapiens OX=9606 GN=CD14 PE=1 SV=2	7	7	75	cell death;defense response;regulation of biological process;response to stimulus;transport	cell surface;extracellular;Golgi;membrane	protein binding;receptor activity;signal transducer activity	CD14	Regulation of toll-like receptor signaling pathway; Pathogenic Escherichia coli infection; MAPK Signaling Pathway; Regulation of Actin Cytoskeleton; Toll-like receptor signaling pathway	Legionellosis; Salmonella infection; MAPK signaling pathway; Regulation of actin cytoskeleton; Pertussis; Pathogenic Escherichia coli infection; NF-kappa B signaling pathway; Toll-like receptor signaling pathway; Hematopoietic cell lineage; Transcriptional misregulation in cancer; Amoebiasis; Phagosome; Tuberculosis	MyD88:Mal cascade initiated on plasma membrane; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; Ligand-dependent caspase activation; IRAK4 deficiency (TLR2/4); ER-Phagosome pathway; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Activated TLR4 signalling; Neutrophil degranulation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of TLR by endogenous ligand; TRIF-mediated programmed cell death; Transfer of LPS from LBP carrier to CD14; TICAM1,TRAF6-dependent induction of TAK1 complex; MyD88 deficiency (TLR2/4)	-1.354566243	1.14e-06	1.09e-05	FDR <= 0.01	21.66150087	21.63487372	21.52724224	21.71649578	21.48588792	20.13860626	20.07020938	20.05439833	20.71141716	20.27853818
H3BTN5	647	P14618-2;H3BTN5;H3BR70	PKM	Pyruvate kinase (Fragment) OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=1	10	1	54	metabolic process	cytosol	catalytic activity;metal ion binding		Amino Acid metabolism			0.240670113	0.065637509	0.099671773	FDR > 0.05	14.65312279	14.57312253	14.54839565	14.73806001	14.36327153	14.98231211	14.66978133	14.73693362	14.66873288	15.02156315
P01854	416	A0A286YES5;P01854	IGHE	Immunoglobulin heavy constant epsilon OS=Homo sapiens OX=9606 GN=IGHE PE=1 SV=1	6	6	35	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHE			FCERI mediated Ca+2 mobilization; Interleukin-4 and 13 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated NF-kB activation	-1.972291869	0.000157499	0.000559895	FDR <= 0.01	20.10297002	20.03729907	19.90738698	20.01822475	19.92289948	18.05132767	18.13405418	16.67290912	19.07846115	18.19056882
P54802	523	P54802	NAGLU	Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2	5	5	22	cell organization and biogenesis;metabolic process;response to stimulus	organelle lumen;vacuole	catalytic activity	NAGLU		Metabolic pathways; Lysosome; Glycosaminoglycan degradation	MPS IIIB - Sanfilippo syndrome B; HS-GAG degradation	-1.107738654	1.15e-06	1.09e-05	FDR <= 0.01	19.08698178	19.12016878	19.1963959	19.29419726	19.18682377	18.2159844	17.85969522	17.96699887	18.31487612	17.98831961
Q9BWP8	697	Q9BWP8-4;Q9BWP8-10;Q9BWP8-7;Q9BWP8-2;Q9BWP8-9;Q9BWP8-6;Q9BWP8;Q9BWP8-5;Q9BWP8-8;Q9BWP8-3	COLEC11	Collectin-11 OS=Homo sapiens OX=9606 GN=COLEC11 PE=1 SV=1	5	5	43	defense response;development;metabolic process;regulation of biological process;response to stimulus;transport	extracellular	catalytic activity	COLEC11		Phagosome	Lectin pathway of complement activation; Scavenging by Class A Receptors	-0.47194891	0.000401557	0.001234789	FDR <= 0.01	21.58922955	21.56432091	21.58773418	21.62418683	21.55414745	21.19050964	20.92541057	21.04996233	21.190534	21.20345783
A0A2Q2TTZ9	307	A0A2Q2TTZ9;P01593	IGKV1D-33	Immunoglobulin kappa variable 1-33 OS=Homo sapiens OX=9606 GN=IGKV1D-33 PE=1 SV=1	3	3	163								0.091394578	0.493781486	0.559255274	FDR > 0.05	22.9656226	22.98041124	22.94675082	23.01057063	23.00512269	23.43297262	22.94932063	23.22556538	22.76172813	22.9958641
P15814	378	P15814	IGLL1	Immunoglobulin lambda-like polypeptide 1 OS=Homo sapiens OX=9606 GN=IGLL1 PE=1 SV=1	5	5	137	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGLL1		Primary immunodeficiency	Cell surface interactions at the vascular wall	-0.196109805	0.214102975	0.270376447	FDR > 0.05	22.65293321	22.60448736	22.49193854	22.6312881	22.32456581	22.78131011	22.32241717	22.45711433	22.05923974	22.10458264
P05089	471	P05089;A0A5F9ZH78;P05089-2;A0A5F9ZGN6;P05089-3	ARG1	Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2	7	7	29	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;metal ion binding	ARG1	Spinal Cord Injury; Amino Acid metabolism; Urea cycle and metabolism of amino groups	Metabolic pathways; Amoebiasis; Arginine and proline metabolism; Biosynthesis of amino acids; Arginine biosynthesis	Urea cycle; Neutrophil degranulation	0.79426319	0.014930146	0.027994023	FDR <= 0.05	19.59650643	19.56211139	19.12516609	19.60835293	19.12530879	19.85606592	20.66279067	20.36144884	20.81634998	19.29210617
Q93063	514	Q93063-2;Q93063-3;Q93063	EXT2	Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1	8	8	41	cell differentiation;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding;protein binding	EXT2	Mesodermal Commitment Pathway	Metabolic pathways; Glycosaminoglycan biosynthesis - heparan sulfate / heparin	HS-GAG biosynthesis; Defective EXT2 causes exostoses 2	0.66871442	0.000368216	0.001167283	FDR <= 0.01	17.69677501	18.05225872	18.10615997	18.01493195	18.1024511	18.70951662	18.68326804	18.60464606	18.37561469	18.94310344
J3KMZ9	566	H0YMD1;P01130-5;J3KMZ9;P01130-4;P01130;P01130-6;P01130-2;P01130-3;H0YM92	LDLR	Low-density lipoprotein receptor (Fragment) OS=Homo sapiens OX=9606 GN=LDLR PE=1 SV=1	7	7	27		cell surface;membrane	metal ion binding;protein binding		Sterol Regulatory Element-Binding Proteins (SREBP) signalling; SREBF and miR33 in cholesterol and lipid homeostasis; Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation; Evolocumab Mechanism; Composition of Lipid Particles			1.236390377	4.57e-07	6.39e-06	FDR <= 0.01	19.63394649	19.90895046	19.86324955	19.91668749	19.71430311	20.7664815	21.14006152	21.17614825	20.99839754	21.13800018
P04406	429	P04406;E7EUT5;P04406-2	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3	8	8	85	cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	catalytic activity;enzyme regulator activity;nucleotide binding;protein binding	GAPDH	Cori Cycle; Alzheimers Disease; Glycolysis and Gluconeogenesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	Metabolic pathways; Alzheimer's disease; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Biosynthesis of amino acids; Carbon metabolism	Gluconeogenesis; Glycolysis	0.544797351	0.142341691	0.187854378	FDR > 0.05	22.25490985	21.89256116	21.89460967	22.15303186	21.83556059	22.0170905	22.75199126	22.39731743	23.88105159	21.7072091
P01782	160	P01782;P0DP04	IGHV3-9	Immunoglobulin heavy variable 3-9 OS=Homo sapiens OX=9606 GN=IGHV3-9 PE=1 SV=2	3	3	187	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-9			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.002877271	0.988574937	0.990184994	FDR > 0.05	23.13099499	23.25740239	23.21285501	23.22916137	23.19805392	23.71496912	23.08027047	23.65783515	22.7327537	22.82825291
Q96RD9	716	Q96RD9;Q96RD9-3;Q96RD9-4	FCRL5	Fc receptor-like protein 5 OS=Homo sapiens OX=9606 GN=FCRL5 PE=1 SV=3	7	7	39		membrane	protein binding	FCRL5				0.580976721	0.001095325	0.002916124	FDR <= 0.01	18.97605982	19.08481689	19.01258253	19.04408838	19.1551454	19.61392768	19.55796276	20.06781336	19.36866586	19.56920696
P33151	667	P33151;P33151-2;I3L1J2	CDH5	Cadherin-5 OS=Homo sapiens OX=9606 GN=CDH5 PE=1 SV=5	8	8	40	cell organization and biogenesis;regulation of biological process;response to stimulus	cell surface;membrane	metal ion binding;protein binding	CDH5	VEGFA-VEGFR2 Signaling Pathway	Leukocyte transendothelial migration; Cell adhesion molecules (CAMs)	VEGFR2 mediated vascular permeability; Adherens junctions interactions	-1.532270062	1.6e-07	3.78e-06	FDR <= 0.01	21.82758069	21.75556551	21.69251707	21.76361792	21.66277844	20.2634751	19.98323011	19.95305711	20.55583744	20.28510956
P02042	67	P02042;E9PFT6;E9PEW8;C9JRG0	HBD	Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2	6	2	115	coagulation;transport	cytosol	metal ion binding;protein binding;transporter activity	HBD			Factors involved in megakaryocyte development and platelet production	2.199848794	5.81e-08	2.55e-06	FDR <= 0.01	17.51954375	17.65478454	17.46459611	17.67581802	17.52099032	19.86458413	20.02832937	19.8623153	19.13270202	19.94704589
P06702	393	P06702	S100A9	Protein S100-A9 OS=Homo sapiens OX=9606 GN=S100A9 PE=1 SV=1	7	7	76	cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	antioxidant activity;catalytic activity;metal ion binding;protein binding;signal transducer activity	S100A9	IL1 and megakaryocytes in obesity		Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand	0.605089002	0.04458582	0.071593419	FDR > 0.05	21.90938534	22.39426008	22.28336	23.04512999	22.43587837	22.65500273	23.02092311	23.08560178	23.81984271	22.51208846
Q16394	547	Q16394;H7C1H6	EXT1	Exostosin-1 OS=Homo sapiens OX=9606 GN=EXT1 PE=1 SV=2	9	9	34	cellular component movement;metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding;protein binding	EXT1	Endoderm Differentiation; Mesodermal Commitment Pathway	Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways	HS-GAG biosynthesis; Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.732937111	9.31e-05	0.00034925	FDR <= 0.01	19.29421548	19.23330201	19.24961349	19.19518516	19.14956018	19.98081539	20.31539211	19.96614064	19.7342898	19.78992393
Q15485	182	Q15485;Q15485-2	FCN2	Ficolin-2 OS=Homo sapiens OX=9606 GN=FCN2 PE=1 SV=2	6	6	93	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding;protein binding	FCN2			Ficolins bind to repetitive carbohydrate structures on the target cell surface	2.114181908	7.14e-07	8.04e-06	FDR <= 0.01	21.79933673	21.99290562	21.89455672	21.96205574	21.87760989	24.3172372	23.40755273	24.48337488	23.60643764	24.28277179
Q6UX71	306	Q6UX71-2;Q6UX71	PLXDC2	Plexin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PLXDC2 PE=1 SV=1	6	5	37		membrane	protein binding	PLXDC2				-1.362089162	1.04e-06	1.07e-05	FDR <= 0.01	19.8987461	20.02577582	19.82983487	19.8889465	19.87467632	18.57931185	18.69824329	18.22972383	18.8991454	18.30110944
P04083	568	P04083;Q5T3N1;Q5T3N0	ANXA1	Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2	5	5	35	cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytoskeleton;cytosol;endosome;extracellular;membrane;nucleus;vacuole	catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding;structural molecule activity	ANXA1	Integrated Breast Cancer Pathway; Spinal Cord Injury; VEGFA-VEGFR2 Signaling Pathway; Prostaglandin Synthesis and Regulation		Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events; Smooth Muscle Contraction; Interleukin-4 and 13 signaling; Formyl peptide receptors bind formyl peptides and many other ligands	1.015157958	0.037189759	0.061483069	FDR > 0.05	18.38638211	18.5110673	18.33380024	20.62352289	18.88579672	19.55209635	20.17551276	20.58265849	20.12287051	19.38322094
Q92820	129	Q92820;A0A7I2YQQ3;A0A7I2V5P2;A0A7I2V5X9	GGH	Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2	7	7	37	metabolic process;response to stimulus;transport	cytosol;extracellular;nucleus;organelle lumen;vacuole	catalytic activity	GGH	Fluoropyrimidine Activity	Folate biosynthesis; Antifolate resistance	Neutrophil degranulation	-0.302428689	0.012407275	0.024300873	FDR <= 0.05	19.90990442	20.05873339	19.95988518	20.18317805	20.01795821	19.67225906	19.89538308	19.67314222	19.78921271	19.58751873
Q13201	188	Q13201;E7EPG1	MMRN1	Multimerin-1 OS=Homo sapiens OX=9606 GN=MMRN1 PE=1 SV=3	5	5	27	cell organization and biogenesis;coagulation;transport	cytoskeleton;extracellular;organelle lumen	metal ion binding;protein binding	MMRN1			Platelet degranulation	1.373258966	2.17e-05	0.000106506	FDR <= 0.01	17.20827252	17.7800666	17.43223326	17.59665859	17.54928882	18.94720187	19.41921227	18.42643206	18.58026645	19.05970198
Q9UGM5	545	Q9UGM5;E9PG08;Q9UGM5-2;C9JC68	FETUB	Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2	8	8	38	regulation of biological process	extracellular	enzyme regulator activity	FETUB				-2.744617999	2.07e-07	4.29e-06	FDR <= 0.01	23.22249023	23.14985845	23.0995818	23.18680145	22.96743827	20.30883008	20.27898396	20.01964034	21.3396253	19.95600054
P01825	390	P01825;A0A0C4DH41	IGHV4-59	Immunoglobulin heavy variable 4-59 OS=Homo sapiens OX=9606 GN=IGHV4-59 PE=1 SV=2	4	1	198	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV4-59			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.398650322	0.046274382	0.073918819	FDR > 0.05	16.76440482	16.91260025	16.89729392	16.9320531	16.97712044	17.30330781	17.16531411	17.91011954	16.80445509	17.29352759
P26038	361	P26038;V9GZ54	MSN	Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3	9	7	36	cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytoskeleton;cytosol;membrane;nucleus	protein binding;RNA binding;structural molecule activity	MSN	Glial Cell Differentiation; AGE/RAGE pathway; Regulation of Actin Cytoskeleton	Measles; Proteoglycans in cancer; Leukocyte transendothelial migration; Regulation of actin cytoskeleton	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Recycling pathway of L1	-0.543137399	0.044302524	0.071324743	FDR > 0.05	19.20352906	19.23887949	19.10600837	19.25319354	19.30617626	18.70736805	19.05091239	18.11398634	19.40941194	18.11042101
P00746	573	P00746;K7ERG9	CFD	Complement factor D OS=Homo sapiens OX=9606 GN=CFD PE=1 SV=5	5	5	32	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	catalytic activity	CFD	Adipogenesis; Complement Activation; Complement and Coagulation Cascades	Complement and coagulation cascades; Staphylococcus aureus infection	Platelet degranulation ; Alternative complement activation; Neutrophil degranulation	-1.552234438	5.82e-07	7.16e-06	FDR <= 0.01	21.72579228	21.71712008	21.5801017	21.34471495	21.48169842	19.97460057	20.02531312	19.78562837	20.47514892	19.82756426
P23083	223	P23083	IGHV1-2	Immunoglobulin heavy variable 1-2 OS=Homo sapiens OX=9606 GN=IGHV1-2 PE=1 SV=2	4	2	42	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV1OR15-1			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.029838605	0.874804633	0.893695763	FDR > 0.05	21.43592491	21.39027995	21.32928121	21.51783745	21.33049551	21.96187677	21.63914162	21.55286904	20.96835433	21.0307703
Q12860	577	Q12860;Q12860-2;Q12860-3;H0YIJ1	CNTN1	Contactin-1 OS=Homo sapiens OX=9606 GN=CNTN1 PE=1 SV=1	7	7	32	cell organization and biogenesis;regulation of biological process;response to stimulus	membrane	protein binding	CNTN1		Cell adhesion molecules (CAMs)	Activated NOTCH1 Transmits Signal to the Nucleus; NOTCH2 Activation and Transmission of Signal to the Nucleus; Neurofascin interactions	-0.707570734	2.27e-05	0.000108063	FDR <= 0.01	19.42634843	19.46093072	19.35013724	19.50315306	19.42361617	18.78267365	18.70332048	18.48904515	18.82020021	18.83109246
A0A0C4DH38	396	A0A0C4DH38	IGHV5-51	Immunoglobulin heavy variable 5-51 OS=Homo sapiens OX=9606 GN=IGHV5-51 PE=3 SV=1	4	2	221	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV5-51				0.225004207	0.399224211	0.472398361	FDR > 0.05	23.91208649	24.13283344	23.96382448	24.06461053	23.96281237	24.77687458	23.67067515	25.01231952	23.72802222	23.97329688
P01763	167	P01763	IGHV3-48	Immunoglobulin heavy variable 3-48 OS=Homo sapiens OX=9606 GN=IGHV3-48 PE=1 SV=2	4	3	75	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-48			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.28297033	0.103393567	0.145108965	FDR > 0.05	19.61415965	19.85690367	19.92409864	19.94447363	19.97544517	20.42556753	19.77359376	20.43285707	19.82658564	20.2713284
P09172	622	P09172	DBH	Dopamine beta-hydroxylase OS=Homo sapiens OX=9606 GN=DBH PE=1 SV=3	6	6	34	cell communication;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding	DBH	Amino Acid metabolism; Biogenic Amine Synthesis; Monoamine Transport	Tyrosine metabolism; Metabolic pathways	Catecholamine biosynthesis	-0.011052089	0.948835078	0.959759166	FDR > 0.05	19.69914118	19.75184471	19.70203435	19.81245568	19.60268475	20.14405486	20.03106635	19.30653827	19.63784549	19.39339526
P05452	337	P05452;E9PHK0	CLEC3B	Tetranectin OS=Homo sapiens OX=9606 GN=CLEC3B PE=1 SV=3	7	7	58	regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;organelle lumen	metal ion binding;protein binding	CLEC3B			Platelet degranulation	-0.765255299	8.92e-06	5.36e-05	FDR <= 0.01	21.22252397	21.28123402	21.08778561	21.26579627	21.06991123	20.41119525	20.4107015	20.33824793	20.58919341	20.35163652
P01824	653	P01824	IGHV4-39	Immunoglobulin heavy variable 4-39 OS=Homo sapiens OX=9606 GN=IGHV4-39 PE=1 SV=2	4	1	202	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;protein binding	IGHV4-39			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.228712006	0.172763989	0.223683902	FDR > 0.05	23.09562564	23.39791246	23.30220675	23.58384594	23.48768854	23.75333518	23.39434575	23.98315093	23.24236847	23.63763903
Q13867	591	Q13867;J3KSD8;K7ES02;K7ESE8	BLMH	Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1	7	7	40	metabolic process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	BLMH			Antigen processing: Ubiquitination & Proteasome degradation	0.603221967	0.093032332	0.133057871	FDR > 0.05	19.3101474	19.95074464	19.41060564	19.23895315	19.1450228	19.4443989	20.14726157	20.02082918	21.18618858	19.27290524
P01814	265	P01814	IGHV2-70	Immunoglobulin heavy variable 2-70 OS=Homo sapiens OX=9606 GN=IGHV2-70 PE=1 SV=2	3	1	25	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV2-70			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.077451707	0.785854874	0.820544563	FDR > 0.05	22.00658571	22.02600156	21.74972658	21.85491378	21.6107612	22.30485725	21.94879666	22.45811699	21.06320477	21.08575462
P02654	466	K7ERI9;P02654;K7ELM9;K7EJI9;K7EPF9;K7EKP1	APOC1	Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1	6	6	88	cell organization and biogenesis;metabolic process;regulation of biological process;transport	endoplasmic reticulum;extracellular	enzyme regulator activity	APOC1	Statin Pathway		VLDL clearance; VLDL assembly	0.496383631	0.084764155	0.123530699	FDR > 0.05	25.52303975	25.38590512	25.20470017	25.41554229	25.21971032	25.83128196	24.80646831	26.30451796	25.92218002	26.36636755
A0A0J9YVU5	592	A0A0J9YVU5;A0A0C4DH43	IGHV2-70	Immunoglobulin heavy variable 2-70 (Fragment) OS=Homo sapiens OX=9606 GN=IGHV2-70 PE=1 SV=1	3	1	39								-0.070383497	0.552813162	0.61147499	FDR > 0.05	21.00574693	21.00511594	20.90210511	21.03067385	20.90352084	21.06270116	21.04864906	21.03099278	20.64860792	20.70429426
Q15063	31	Q15063-6;Q15063-3;Q15063-7;B1ALD9;Q15063-2;Q15063-5;Q15063-4;Q15063	POSTN	Periostin OS=Homo sapiens OX=9606 GN=POSTN PE=1 SV=2	6	6	22	cell communication;cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;extracellular;Golgi	metal ion binding;protein binding	POSTN	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits			0.527713186	0.001713303	0.004336137	FDR <= 0.01	17.61006191	17.67582934	17.604187	17.79824322	17.62428151	18.39008202	18.40371617	18.2918185	17.98166967	17.88388256
P01780	314	P01780	IGHV3-7	Immunoglobulin heavy variable 3-7 OS=Homo sapiens OX=9606 GN=IGHV3-7 PE=1 SV=2	5	4	192	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-7			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.112881712	0.680221713	0.722515291	FDR > 0.05	26.30401329	26.18909882	26.0381801	26.16034303	26.06494403	27.09230206	26.51193002	26.50416515	25.60601606	25.60657454
P22352	411	A0A087X1J7;P22352;H0YBE4	GPX3	Glutathione peroxidase 3 OS=Homo sapiens OX=9606 GN=GPX3 PE=1 SV=2	6	6	68	cell organization and biogenesis;metabolic process;response to stimulus	extracellular	antioxidant activity;catalytic activity;protein binding	GPX3	Glutathione metabolism; Selenium Micronutrient Network; Folate Metabolism; Selenium Metabolism and Selenoproteins; NRF2 pathway; One carbon metabolism and related pathways; Oxidative Stress; Metapathway biotransformation	Glutathione metabolism; Thyroid hormone synthesis; Arachidonic acid metabolism	Detoxification of Reactive Oxygen Species	-1.353891606	1.84e-07	4.19e-06	FDR <= 0.01	23.49426585	23.46606801	23.43389615	23.30945827	23.37332396	22.17729702	22.06618625	21.84553625	22.3224426	21.8960921
P30101	473	P30101;H7BZJ3	PDIA3	Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4	7	7	24	cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endoplasmic reticulum;membrane;nucleus;organelle lumen	catalytic activity;protein binding;RNA binding	PDIA3		Protein processing in endoplasmic reticulum; Antigen processing and presentation	ER-Phagosome pathway; Calnexin/calreticulin cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC	-0.057365633	0.700078912	0.737240635	FDR > 0.05	19.82116486	19.72925505	19.71746929	19.83142688	19.75901708	19.71945036	19.58556956	19.29391472	20.12358126	19.84898911
P02741	324	P02741;Q5VVP7;P02741-2	CRP	C-reactive protein OS=Homo sapiens OX=9606 GN=CRP PE=1 SV=1	7	7	36	defense response;regulation of biological process;response to stimulus	extracellular	metal ion binding;protein binding	CRP	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Overview of nanoparticle effects; IL-6 signaling pathway		Classical antibody-mediated complement activation	1.058692567	0.062135683	0.095533613	FDR > 0.05	24.49871477	24.54270113	24.37317078	24.42953028	24.19155272	24.75508832	24.35135824	26.68848131	24.50653652	27.02766814
Q01459	382	Q01459	CTBS	Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1	6	6	49	metabolic process	vacuole	catalytic activity	CTBS				-2.092516669	4.76e-08	2.44e-06	FDR <= 0.01	20.23443295	20.17198051	20.15943766	20.15925972	20.06132853	18.04257576	17.96712178	17.93099974	18.63100911	17.75214962
Q7Z7G0	86	Q7Z7G0-2;D3YTG3;H0Y897;Q7Z7G0-3;Q7Z7G0-4;H7C556;Q7Z7G0	ABI3BP	Target of Nesh-SH3 OS=Homo sapiens OX=9606 GN=ABI3BP PE=1 SV=1	6	6	28	cell organization and biogenesis;regulation of biological process	extracellular	protein binding	ABI3BP				-0.748252109	4.66e-06	3.13e-05	FDR <= 0.01	19.68233027	19.64468614	19.49258079	19.53383114	19.58006356	18.79574464	18.7782909	18.85354389	18.9301842	18.83446773
P09960	679	P09960-4;P09960;P09960-3;P09960-2	LTA4H	Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2	7	7	30	metabolic process;transport	cytoplasm;cytosol;extracellular;nucleus	catalytic activity;metal ion binding;protein binding;RNA binding	LTA4H	Eicosanoid Synthesis	Metabolic pathways; Arachidonic acid metabolism	Synthesis of Leukotrienes (LT) and Eoxins (EX); Neutrophil degranulation	-0.448656392	0.023299918	0.040593342	FDR <= 0.05	20.20797381	20.24565151	20.19732524	20.20343226	20.05832673	19.50783366	19.32420347	19.5821776	20.23161245	20.02360041
A0A0B4J1V0	181	A0A0B4J1V0	IGHV3-15	Immunoglobulin heavy variable 3-15 OS=Homo sapiens OX=9606 GN=IGHV3-15 PE=3 SV=1	6	5	162	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-15				0.456930347	0.019781465	0.035625207	FDR <= 0.05	25.30856259	25.0733397	25.27388754	25.2256371	25.22421666	26.31450016	25.65380408	25.53895975	25.4216753	25.46135604
A0A0J9YXX1	366	A0A0J9YXX1	IGHV5-10-1	Immunoglobulin heavy variable 5-10-1 OS=Homo sapiens OX=9606 GN=IGHV5-10-1 PE=3 SV=1	4	2	155	response to stimulus	extracellular;membrane		IGHV5-A; IGHV5-10-1				0.576346519	0.071668654	0.107241416	FDR > 0.05	22.06328118	22.01690922	21.93829902	21.85120521	21.85916374	22.61231235	21.99357154	23.64578885	21.85228545	22.50663277
Q92859	536	Q92859-4;Q92859-3;Q92859-2;Q92859;Q59FP8	NEO1	Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2	6	6	22	cellular component movement;regulation of biological process	Golgi;membrane	protein binding;receptor activity	NEO1		Cell adhesion molecules (CAMs)	Netrin-1 signaling; CDO in myogenesis	-0.264368872	0.461784472	0.534835122	FDR > 0.05	19.94084287	20.02212455	19.95270778	19.97504618	19.96870525	19.41321984	21.25431226	19.26537227	19.35888784	19.24579006
P01768	58	P01768	IGHV3-30	Immunoglobulin heavy variable 3-30 OS=Homo sapiens OX=9606 GN=IGHV3-30 PE=1 SV=2	6	1	188	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-30; IGHV3-30-5			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	1.184516453	0.000218886	0.00074786	FDR <= 0.01	19.32758323	19.66466666	19.34903571	19.66426954	19.48937414	21.35575747	20.08541377	20.77353807	20.34121851	20.86158372
A0A0J9YY99	193	A0A0J9YY99		Ig-like domain-containing protein (Fragment) OS=Homo sapiens OX=9606 PE=1 SV=1	7	2	209								0.283497975	0.2563087	0.321013677	FDR > 0.05	25.4317735	25.48855257	25.37793989	25.48261794	25.28808779	26.36985789	25.78354698	26.02865946	24.90495883	25.3994384
O95479	508	O95479-2;O95479	H6PD	GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2	5	5	39	metabolic process	endoplasmic reticulum;organelle lumen	catalytic activity;nucleotide binding	H6PD		Pentose phosphate pathway; Metabolic pathways; Carbon metabolism		-0.444248502	0.001106803	0.002933982	FDR <= 0.01	19.0981335	19.07751181	19.04474714	18.90548706	18.96218718	18.52648976	18.77311726	18.42758324	18.6400156	18.49961833
A0A075B6R2	645	A0A075B6R2	IGHV4-4	Immunoglobulin heavy variable 4-4 OS=Homo sapiens OX=9606 GN=IGHV4-4 PE=3 SV=2	3	1	108	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV4-4				1.490539534	0.000405573	0.001240934	FDR <= 0.01	20.77376006	20.78156197	20.79631814	20.7905519	20.67670714	23.1789338	21.75448978	22.85980172	21.49684216	21.98152943
P55268	304	P55268;F5H520	LAMB2	Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2	7	7	31	cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;extracellular;Golgi;organelle lumen	catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity	LAMB2	Alpha 6 Beta 4 signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway	Toxoplasmosis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Focal adhesion; Amoebiasis	ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions	0.332497838	0.017059549	0.031318276	FDR <= 0.05	17.45304299	17.47153197	17.36166075	17.38703769	17.39732785	17.45942511	18.02969866	17.8007948	17.61022392	17.83294795
A0A1B0GU92	4	A0A1B0GVD5;A0A1B0GV23;A0A1B0GU92;C9JH19;P07339;A0A1B0GU03;A0A1B0GWE8;F8W787;A0A1B0GW44;H7C469;A0A1B0GVP3;F8WD96		Peptidase A1 domain-containing protein OS=Homo sapiens OX=9606 PE=1 SV=1	5	5	33	metabolic process;response to stimulus	membrane;vacuole	catalytic activity					-0.301266419	0.26366187	0.328243016	FDR > 0.05	21.01064614	21.0262867	21.00478998	20.91840697	20.93936195	20.13446069	21.27909857	20.81850167	21.23495672	19.92614199
P12273	327	P12273	PIP	Prolactin-inducible protein OS=Homo sapiens OX=9606 GN=PIP PE=1 SV=1	5	5	43	metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;nucleus	catalytic activity;protein binding	PIP			Miscellaneous transport and binding events	0.759767364	0.001273292	0.003346473	FDR <= 0.01	20.56326431	20.85929727	20.7533537	21.2225713	21.05814496	21.4540434	21.93286757	21.82105278	21.84022122	21.20728339
P01766	542	P01766	IGHV3-13	Immunoglobulin heavy variable 3-13 OS=Homo sapiens OX=9606 GN=IGHV3-13 PE=1 SV=2	3	3	94	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-13			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.136548687	0.546982226	0.606115439	FDR > 0.05	21.06691923	21.12126789	21.08912123	21.05903891	21.1072991	21.4967327	20.97946169	21.41658901	20.26368147	20.60443807
O60462	111	O60462-4;O60462-5;O60462-2;O60462;O60462-3;O60462-6;C9JH98	NRP2	Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 PE=1 SV=3	6	6	27	cell growth;cellular component movement;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	NRP2	VEGFA-VEGFR2 Signaling Pathway			0.414549751	0.04076493	0.066389021	FDR > 0.05	19.20475097	19.22592561	19.20990319	19.28973892	19.26392998	19.3697046	19.71206183	20.11309666	19.12053649	19.95159784
P22897	509	P22897;P22897-2	MRC1	Macrophage mannose receptor 1 OS=Homo sapiens OX=9606 GN=MRC1 PE=1 SV=1	6	6	30	regulation of biological process;response to stimulus;transport	cell surface;endosome;membrane	protein binding;receptor activity;signal transducer activity	MRC1		Phagosome; Tuberculosis	Cross-presentation of soluble exogenous antigens (endosomes)	-0.254154984	0.012659202	0.024715585	FDR <= 0.05	20.48980937	20.58248776	20.6037924	20.55759351	20.60197411	20.28732659	20.42210223	20.28285421	20.2861604	20.2864388
D6RE86	504	D6RE86	CP	Ceruloplasmin (Fragment) OS=Homo sapiens OX=9606 GN=CP PE=1 SV=8	5	1	21	cellular homeostasis;metabolic process;transport		catalytic activity;metal ion binding					-0.207764582	0.126811991	0.170261856	FDR > 0.05	14.17169742	14.27524743	14.22536811	14.01074051	13.90604717	13.99824062	13.95608726	14.07151676	13.56902848	13.95540461
P55056	165	P55056	APOC4	Apolipoprotein C-IV OS=Homo sapiens OX=9606 GN=APOC4 PE=1 SV=1	5	3	57	cell organization and biogenesis;metabolic process;regulation of biological process;transport	extracellular	transporter activity	APOC4; APOC4-APOC2			VLDL clearance; VLDL assembly	0.983990385	1.3e-05	7e-05	FDR <= 0.01	20.26649797	20.34167837	20.20714526	20.31246826	20.20593619	21.35477474	21.40890742	21.24800177	20.81096363	21.43103042
Q8NBP7	245	Q8NBP7;A0A669KBG0;A0A669KB81;Q8NBP7-2;A0A669KAY4	PCSK9	Proprotein convertase subtilisin/kexin type 9 OS=Homo sapiens OX=9606 GN=PCSK9 PE=1 SV=3	6	6	28	cell communication;cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;organelle lumen;vacuole	catalytic activity;protein binding;RNA binding	PCSK9	Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation; Evolocumab Mechanism		Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); LDL clearance; VLDLR internalisation and degradation	-0.590738765	0.004021541	0.009026451	FDR <= 0.01	19.86969624	19.98038024	19.99319343	19.98788198	20.00145603	19.37632749	18.77452094	19.72122759	19.48489113	19.52194694
P32119	693	P32119;A6NIW5	PRDX2	Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5	6	5	30	cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	antioxidant activity;catalytic activity;protein binding	PRDX2	Selenium Micronutrient Network		TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species	0.546438242	0.032232945	0.054310305	FDR > 0.05	20.5334147	20.30263275	20.20609696	20.52814175	20.12077075	20.3094849	21.3698854	21.20142588	21.16234172	20.38011022
A0A0C4DH29	106	A0A0C4DH29	IGHV1-3	Immunoglobulin heavy variable 1-3 OS=Homo sapiens OX=9606 GN=IGHV1-3 PE=3 SV=1	5	3	76	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV1-3				0.77174055	0.003229568	0.00763917	FDR <= 0.01	21.3285184	21.70351178	21.35894587	21.44614483	21.37472508	22.52594593	22.19202092	22.75008217	21.55796171	22.04453799
P01767	705	P01767;A0A0C4DH42	IGHV3-53	Immunoglobulin heavy variable 3-53 OS=Homo sapiens OX=9606 GN=IGHV3-53 PE=1 SV=2	5	2	63	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-53			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.580027365	0.00327866	0.007725578	FDR <= 0.01	18.54844222	18.7031427	18.57894937	18.70051784	18.68172823	19.66081253	19.31924362	19.26902517	18.75106847	19.1127674
P08670	108	B0YJC4;P08670;B0YJC5;A0A1B0GTT5	VIM	Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4	7	6	42	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;RNA binding;structural molecule activity	VIM	Allograft Rejection; Spinal Cord Injury; Primary Focal Segmental Glomerulosclerosis FSGS; Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated Muscle Contraction; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; T-Cell antigen Receptor (TCR)  Signaling Pathway	Epstein-Barr virus infection; MicroRNAs in cancer	Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction	1.210287925	0.007951449	0.016300471	FDR <= 0.05	18.41121384	18.47237412	18.43788829	18.45029893	19.35842638	19.43039218	19.24342728	19.2831865	21.24109141	19.98354382
G8JLG2	338	Q15517;G8JLG2;Q2L6G8	CDSN	Corneodesmosin OS=Homo sapiens OX=9606 GN=CDSN PE=1 SV=1	3	3	19	cell death;cell differentiation;regulation of biological process	cytoskeleton;membrane	protein binding	CDSN				0.299056418	0.072715847	0.108544287	FDR > 0.05	21.10473697	21.26040739	21.09927305	21.25482052	21.06930249	21.46161555	21.75298758	21.69365407	21.42009719	20.95546814
P31151	200	P31151;Q86SG5	S100A7	Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4	5	5	48	cell differentiation;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;endoplasmic reticulum;extracellular;nucleus;organelle lumen	metal ion binding;protein binding	S100A7			Neutrophil degranulation; Metal sequestration by antimicrobial proteins	0.598133682	0.003514754	0.008095783	FDR <= 0.01	18.27412788	18.67238299	18.42254427	18.71119674	18.3824224	18.86035575	19.41881524	18.98577236	19.40818952	18.78020982
P07737	472	P07737;K7EJ44;I3L3D5	PFN1	Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2	5	5	34	cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus	enzyme regulator activity;nucleotide binding;protein binding;RNA binding	PFN1	Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway	Salmonella infection; Regulation of actin cytoskeleton; Rap1 signaling pathway; Shigellosis	Platelet degranulation ; Signaling by ROBO receptors; RHO GTPases Activate Formins; PCP/CE pathway	-0.298494019	0.207827779	0.263534194	FDR > 0.05	19.51790868	19.67809314	19.64018764	19.76060073	20.03037344	19.19345514	19.17039638	18.89116795	20.12187815	19.75779592
P67936-2	175	P67936-2;A0A2R8YHD2;A0A2R8YE05;A0A2R8Y5V9;A0A2R8YH90;P67936;K7ENT6;A7XZE4;P07951;Q5TCU3;P07951-2;A0A5F9UN72;A0A2R8YGX3;A0A2R8YEU4;P07951-3;U3KQK2;K7ELP0;K7EPB9	TPM4	Isoform 2 of Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4	8	3	38	cell differentiation;cell organization and biogenesis;cellular component movement	cytoskeleton;cytosol;membrane	metal ion binding;protein binding;structural molecule activity	TPM4	Striated Muscle Contraction			1.015111617	0.000415063	0.001263682	FDR <= 0.01	20.04479449	19.97230672	19.93139118	20.05879257	20.24546493	20.69272078	20.97232548	20.62523258	21.73465169	21.30337745
Q76LX8	404	Q76LX8-3;Q76LX8;Q76LX8-2;Q76LX8-4;E7EV88	ADAMTS13	A disintegrin and metalloproteinase with thrombospondin motifs 13 OS=Homo sapiens OX=9606 GN=ADAMTS13 PE=1 SV=1	4	4	19	coagulation;metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;organelle lumen	catalytic activity;metal ion binding;protein binding	ADAMTS13			O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS)	-1.097702045	7.76e-06	4.77e-05	FDR <= 0.01	19.05681243	18.99778971	19.05716579	18.95510325	19.1555948	17.54001157	17.78383557	18.09280014	18.17554587	18.1417626
Q15389	256	Q15389-2;Q15389;B4DTQ9;E7ERK4	ANGPT1	Angiopoietin-1 OS=Homo sapiens OX=9606 GN=ANGPT1 PE=1 SV=2	6	6	28	cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	ANGPT1	Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	Rap1 signaling pathway; PI3K-Akt signaling pathway; Rheumatoid arthritis; Ras signaling pathway; HIF-1 signaling pathway	Tie2 Signaling; RAF/MAP kinase cascade; Interleukin-20 family signaling	1.627127584	0.000714979	0.002017028	FDR <= 0.01	17.22469028	17.28189326	17.46946855	17.32177199	17.37643837	18.61830899	17.83271141	19.79037803	18.69755189	19.87095004
P06732	221	P06732	CKM	Creatine kinase M-type OS=Homo sapiens OX=9606 GN=CKM PE=1 SV=2	6	6	24	metabolic process	cytoplasm;cytosol	catalytic activity;nucleotide binding;protein binding	CKM	Urea cycle and metabolism of amino groups	Arginine and proline metabolism; Metabolic pathways	Creatine metabolism	-1.440158579	8e-08	3.04e-06	FDR <= 0.01	19.9183049	19.90116288	19.83929149	19.98197836	19.80527314	18.59908239	18.33682573	18.3150451	18.70472647	18.28953819
A0A0B4J259	70	A0A0B4J259;F8VV32;P61626	LYZ	1,4-beta-N-acetylmuramidase C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1	6	6	78	defense response;metabolic process;response to stimulus		catalytic activity					0.581023368	0.140773286	0.186184023	FDR > 0.05	21.32376243	21.04024775	20.91993276	21.80798341	21.3911517	22.0052408	22.99126267	22.0221412	21.75554769	20.61400254
Q9UQP3	322	Q9UQP3;A0A087WXC4;A0A087WXT0	TNN	Tenascin-N OS=Homo sapiens OX=9606 GN=TNN PE=1 SV=2	6	6	25	cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process	cell surface;extracellular	protein binding	TNN	Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; MicroRNAs in cancer	ECM proteoglycans	0.117082542	0.482924185	0.553534533	FDR > 0.05	18.56093769	18.54000712	18.57127692	18.63597017	18.62249761	18.50634028	18.35741276	19.1691403	18.48132378	19.0018851
A0A0A0MT96	371	A0A0A0MT96	IGKJ3	Immunoglobulin kappa joining 3 (Fragment) OS=Homo sapiens OX=9606 GN=IGKJ3 PE=4 SV=1	7	7	18								-0.090250088	0.689789957	0.730156323	FDR > 0.05	20.60997924	20.57896868	20.47138709	20.57881029	20.36143693	20.6691054	20.09685874	19.68966078	20.77503882	20.91866805
Q8N6C8	443	A0A0G2JMY9;Q8N6C8-2;Q8N6C8;Q8N6C8-3	LILRA3	Leukocyte immunoglobulin-like receptor subfamily A member 3 OS=Homo sapiens OX=9606 GN=LILRA3 PE=1 SV=3	3	3	12	defense response;regulation of biological process;response to stimulus;transport	extracellular;membrane	protein binding;receptor activity	LILRA3		Osteoclast differentiation	Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	-1.01576522	8.19e-06	4.98e-05	FDR <= 0.01	19.4265298	19.43445106	19.37885381	19.43068959	19.28455976	18.06826619	18.57925763	18.15501015	18.59897626	18.4747477
A0A075B6K4	321	A0A075B6K4	IGLV3-10	Immunoglobulin lambda variable 3-10 OS=Homo sapiens OX=9606 GN=IGLV3-10 PE=3 SV=2	4	3	97	response to stimulus	extracellular;membrane		IGLV3-10				0.32242642	0.122285941	0.164925118	FDR > 0.05	24.78100424	24.73068443	24.65427641	24.79634162	24.5000427	25.22797046	24.58974654	25.61990023	24.61485242	25.02201185
A0A0B4J1V6	709	A0A0B4J1V6	IGHV3-73	Immunoglobulin heavy variable 3-73 OS=Homo sapiens OX=9606 GN=IGHV3-73 PE=3 SV=1	4	2	83	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-73				0.664292588	0.001440009	0.003721033	FDR <= 0.01	20.66915951	20.80367836	20.62397566	20.73714336	20.66730525	21.71051398	21.03365023	21.73455423	21.08347792	21.26052872
A0A075B6Q5	512	A0A075B6Q5	IGHV3-64	Immunoglobulin heavy variable 3-64 OS=Homo sapiens OX=9606 GN=IGHV3-64 PE=3 SV=1	3	1	22	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	LOC100291056; IGHV3-64				0.78101429	0.000870889	0.002391056	FDR <= 0.01	20.36207736	20.38895857	20.29362649	20.42848128	20.368728	21.61327649	20.97286225	21.46756314	20.66700034	21.02624091
Q08188	65	Q08188;A0A494C0J7	TGM3	Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4	6	6	36	cell differentiation;cell organization and biogenesis;metabolic process	cytoplasm	catalytic activity;metal ion binding	TGM3				0.549520264	0.066872748	0.10129739	FDR > 0.05	18.99126091	19.13644483	19.00806966	19.24533332	18.9669218	19.52674642	20.70952236	19.49103723	19.41546001	18.95286583
Q9UM47	686	Q9UM47;M0R3C9	NOTCH3	Neurogenic locus notch homolog protein 3 OS=Homo sapiens OX=9606 GN=NOTCH3 PE=1 SV=2	6	6	23	cell differentiation;development;metabolic process;regulation of biological process;response to stimulus	cytoskeleton;cytosol;extracellular;membrane;nucleus	metal ion binding;protein binding;receptor activity	NOTCH3	Neural Crest Differentiation; Notch Signaling Pathway; Canonical  and Non-canonical Notch signaling; Role of Osx and miRNAs in tooth development; Notch Signaling Pathway	Notch signaling pathway; Dorso-ventral axis formation; Breast cancer; Endocrine resistance; Thyroid hormone signaling pathway; MicroRNAs in cancer; Th1 and Th2 cell differentiation	Defective LFNG causes SCDO3; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; Pre-NOTCH Transcription and Translation; Signaling by NOTCH3; Pre-NOTCH Processing in the Endoplasmic Reticulum	0.116297411	0.495312517	0.559958085	FDR > 0.05	19.61266029	19.5976228	19.59567926	19.63070067	19.4601828	19.23093481	19.87645794	20.19263353	19.50143625	19.67687035
A0A0C4DH67	581	A0A0C4DH67	IGKV1-8	Immunoglobulin kappa variable 1-8 OS=Homo sapiens OX=9606 GN=IGKV1-8 PE=3 SV=1	2	1	47	response to stimulus	extracellular;membrane		IGKV1-8				-0.387559529	0.526855308	0.589357287	FDR > 0.05	19.87810449	19.83816669	19.77207769	19.89709175	19.63102771	21.4385399	20.26075121	17.46310889	19.12827051	18.78800018
E5RHP7	81	P00915;E5RH81;E5RHP7;E5RFL2;E5RIF9;E5RG43;E5RGU8;E5RII2;E5RJI8;E5RJF6;H0YBE2;E5RFE7	CA1	Carbonic anhydrase (Fragment) OS=Homo sapiens OX=9606 GN=CA1 PE=1 SV=1	5	5	32	metabolic process	cytoplasm	catalytic activity;metal ion binding					-1.789404338	7.9e-07	8.38e-06	FDR <= 0.01	20.09120558	20.10020176	20.09243294	20.12265122	20.04105671	18.77072533	18.06482909	17.93912398	18.69834735	18.02750076
P31947	119	P31947-2;P31947	SFN	14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1	6	3	41	cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus	cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus	enzyme regulator activity;protein binding	SFN	miRNA Regulation of DNA Damage Response; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; DNA Damage Response	p53 signaling pathway; Cell cycle; Aldosterone-regulated sodium reabsorption	Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs	0.698081951	0.17690159	0.228080666	FDR > 0.05	18.32170715	18.23215673	18.10746076	19.03391267	18.42517793	18.67519634	18.73453297	18.83545456	21.17124342	18.19439771
F5GZS6	15	F5GZS6;P08195;J3KPF3;P08195-2;P08195-3;P08195-4;F5GZI0	SLC3A2	4F2 cell-surface antigen heavy chain OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=1	5	5	30	metabolic process	cytosol;membrane;nucleus	catalytic activity					-0.082630647	0.46750569	0.539429643	FDR > 0.05	18.17819214	18.33755583	18.13230182	18.17909218	18.25455895	18.30822578	18.34200625	18.04668154	17.9713172	18.00031693
Q9NY15	601	Q9NY15;Q9NY15-2	STAB1	Stabilin-1 OS=Homo sapiens OX=9606 GN=STAB1 PE=1 SV=3	4	4	16	cell communication;defense response;metabolic process;regulation of biological process;response to stimulus;transport	membrane	catalytic activity;metal ion binding;protein binding;receptor activity	STAB1			Scavenging by Class H Receptors	0.313258493	0.047493369	0.075473958	FDR > 0.05	16.72718211	16.8961484	16.94998164	16.36753566	16.89355897	16.97341661	17.17142223	16.9415754	16.96593418	17.34835083
P00338	516	P00338-3;P00338;P00338-4;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2	LDHA	L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2	7	6	39	metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane;nucleus	catalytic activity;nucleotide binding;protein binding	LDHA	Cori Cycle; Photodynamic therapy-induced HIF-1 survival signaling; Amino Acid metabolism; Glycolysis and Gluconeogenesis	Glycolysis / Gluconeogenesis; Central carbon metabolism in cancer; Cysteine and methionine metabolism; Glucagon signaling pathway; HIF-1 signaling pathway; Metabolic pathways; Pyruvate metabolism; Propanoate metabolism	Pyruvate metabolism	-0.14824455	0.721850622	0.757573606	FDR > 0.05	20.06314784	20.10274762	19.94608133	20.15529593	20.08491125	19.55462564	19.41364124	19.67692437	21.72551347	19.24025652
Q6UXB8	358	Q6UXB8;Q6UXB8-2	PI16	Peptidase inhibitor 16 OS=Homo sapiens OX=9606 GN=PI16 PE=1 SV=1	5	5	25	regulation of biological process	extracellular	enzyme regulator activity	PI16				-0.587778983	4.51e-05	0.000190023	FDR <= 0.01	19.65852867	19.81796888	19.77203574	19.87363717	19.84215506	19.16772119	19.19376247	19.13765602	19.28935507	19.23693586
P39060	210	H7C457;P39060-2;P39060-1;H7BXV5;P39060	COL18A1	Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5	3	3	18	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	metal ion binding;protein binding;structural molecule activity	COL18A1		Protein digestion and absorption	Collagen degradation; Activation of Matrix Metalloproteinases; Integrin cell surface interactions; Laminin interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization	-1.917347541	2.19e-07	4.33e-06	FDR <= 0.01	18.59307501	18.61550586	18.51723295	18.58343431	18.46844522	16.49574538	16.39733999	16.35770618	17.25024891	16.68991519
P01699	268	P01699	IGLV1-44	Immunoglobulin lambda variable 1-44 OS=Homo sapiens OX=9606 GN=IGLV1-44 PE=1 SV=2	2	1	18	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV1-44			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.742364059	0.001344336	0.003503249	FDR <= 0.01	20.27880014	20.32913664	20.1822818	20.14782373	20.21636083	21.65357393	20.85076239	20.79589523	20.69023831	20.87575357
A0A0C4DH25	659	A0A0C4DH25	IGKV3D-20	Immunoglobulin kappa variable 3D-20 OS=Homo sapiens OX=9606 GN=IGKV3D-20 PE=3 SV=1	4	2	187	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV3D-20			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.317924771	0.101835399	0.143974185	FDR > 0.05	25.82687413	25.87673343	25.80970575	25.868413	25.78269917	26.16277692	25.58493881	25.48272496	25.20256422	25.14179672
Q6YHK3	633	Q6YHK3;Q6YHK3-4;Q6YHK3-2;Q6YHK3-3	CD109	CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 PE=1 SV=2	6	6	31	metabolic process;regulation of biological process;transport	cell surface;extracellular;membrane	enzyme regulator activity;protein binding	CD109			Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins	-0.214267981	0.283130036	0.34894784	FDR > 0.05	17.83232777	18.00201111	18.10454094	18.94643409	18.04849252	17.98838772	17.90142138	17.90615209	17.97980831	18.08669704
H7BZ94	199	P07237;H7BZ94;I3L398;I3L4M2;H0Y3Z3;I3L312	P4HB	Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=2	5	5	19	cellular homeostasis;regulation of biological process	endoplasmic reticulum	catalytic activity					0.081962676	0.620453813	0.670613524	FDR > 0.05	18.53499491	18.64639342	18.68781502	18.89529054	18.97894551	18.8129205	18.55245422	18.62642225	19.3442479	18.81720791
Q08830	710	Q08830	FGL1	Fibrinogen-like protein 1 OS=Homo sapiens OX=9606 GN=FGL1 PE=1 SV=3	6	6	27		extracellular		FGL1				0.478809369	0.188237529	0.240677921	FDR > 0.05	20.02147052	20.11505523	20.07120544	20.08471112	20.11362377	19.96815023	20.50732176	20.69866858	19.71708197	21.90889039
P14151	156	P14151;P14151-2	SELL	L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 SV=2	5	5	31	cellular component movement;regulation of biological process;response to stimulus;transport	cell surface;membrane	protein binding	SELL		Cell adhesion molecules (CAMs)	Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall	1.049549181	2.29e-05	0.000108151	FDR <= 0.01	19.12724887	19.13559008	19.18695471	19.08665517	19.13056187	20.10487055	20.4128218	19.7182531	20.143798	20.53501315
P60174	521	P60174-3;P60174;P60174-4;U3KPZ0;U3KQF3	TPI1	Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4	5	5	21	development;metabolic process	cytosol;nucleus	catalytic activity;protein binding	TPI1	Fatty Acid Beta Oxidation; Cori Cycle; Glycolysis and Gluconeogenesis			0.305717155	0.472674577	0.544372406	FDR > 0.05	18.30554936	18.46371958	18.07603317	18.82258184	18.16723301	18.26229756	18.5324046	18.10173513	20.42028045	18.04698499
P01762	555	P01762	IGHV3-11	Immunoglobulin heavy variable 3-11 OS=Homo sapiens OX=9606 GN=IGHV3-11 PE=1 SV=2	3	2	103	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGHV3-11			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.551948578	0.001635619	0.004173884	FDR <= 0.01	20.01737865	20.30444514	20.22824394	20.26852281	20.29268687	20.83371524	20.86545637	21.05751044	20.39740712	20.71693114
Q14126	677	Q14126;J3KSI6	DSG2	Desmoglein-2 OS=Homo sapiens OX=9606 GN=DSG2 PE=1 SV=2	4	4	19	cell death;cell organization and biogenesis;regulation of biological process;response to stimulus	cell surface;cytoskeleton;membrane	metal ion binding;protein binding	DSG2	Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope	-0.817497573	4.35e-06	3.01e-05	FDR <= 0.01	16.88676077	16.93209409	16.80991177	17.11986701	16.82801228	16.1717155	16.1035555	16.04348336	16.13065696	16.03974672
A0A0B4J1U7	124	A0A0B4J1U7	IGHV6-1	Immunoglobulin heavy variable 6-1 OS=Homo sapiens OX=9606 GN=IGHV6-1 PE=3 SV=1	3	3	51	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV6-1				1.218351508	0.003080251	0.007458089	FDR <= 0.01	22.00555822	22.06257116	21.91834286	21.9185216	21.83361019	24.0924681	22.94375084	23.89413445	22.29129166	22.60871653
Q08554	702	Q08554-2;Q08554	DSC1	Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2	5	5	28	cell death;transport	cytoskeleton;membrane	metal ion binding	DSC1			Formation of the cornified envelope; Neutrophil degranulation	0.253636039	0.316438321	0.386130095	FDR > 0.05	20.0401512	19.8689734	19.6295373	20.02019799	19.82262229	19.68229568	20.87559969	20.46285123	20.12989419	19.49902158
Q14112	344	Q14112-2;Q14112;A0A087WZP6;H0YJV3	NID2	Nidogen-2 OS=Homo sapiens OX=9606 GN=NID2 PE=1 SV=3	4	4	16	cell organization and biogenesis	cell surface;extracellular;membrane	metal ion binding;protein binding	NID2			Laminin interactions	1.525339155	0.000200549	0.000696824	FDR <= 0.01	14.63397612	14.56225655	14.75247559	14.41227552	14.85234671	16.36123513	15.61672071	16.82539358	15.34304058	16.69363627
P10124	270	P10124	SRGN	Serglycin OS=Homo sapiens OX=9606 GN=SRGN PE=1 SV=3	3	3	12	cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;Golgi;membrane;organelle lumen;vacuole	protein binding	SRGN			Platelet degranulation	2.337246618	0.040764181	0.066389021	FDR > 0.05	15.79767392	16.05353357	16.27494576	16.51784117	16.36198971	19.41533272	17.69831859	20.16813089	14.48606116	20.92437386
P06310	524	P06310	IGKV2-30	Immunoglobulin kappa variable 2-30 OS=Homo sapiens OX=9606 GN=IGKV2-30 PE=3 SV=2	2	1	152	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV2-30			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.607327934	0.021049734	0.037199962	FDR <= 0.05	18.14325167	17.7169717	17.82965391	17.70137832	17.76503715	19.1398441	18.71539606	18.30329586	17.7981245	18.23627189
P0DP01	505	P0DP01	IGHV1-8	Immunoglobulin heavy variable 1-8 OS=Homo sapiens OX=9606 GN=IGHV1-8 PE=3 SV=1	4	2	24	response to stimulus	extracellular;membrane		IGHV1-8				-0.225417432	0.60731715	0.662234127	FDR > 0.05	18.3297599	18.7706832	18.65351594	18.53096897	18.67353232	19.7278069	18.21307419	19.16004091	17.44734401	17.28310717
P02656	179	P02656;B0YIW2	APOC3	Apolipoprotein C-III OS=Homo sapiens OX=9606 GN=APOC3 PE=1 SV=1	3	3	163	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	endosome;extracellular	enzyme regulator activity;protein binding	APOC3	PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway	PPAR signaling pathway	Signaling by GPCR; HDL remodeling; Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling	0.009465801	0.962197819	0.970084687	FDR > 0.05	23.77078622	23.77765698	23.71017936	23.74720582	23.61863561	23.53303352	23.08138592	24.16656654	23.74236859	24.14843842
P0DPH8	37	P68363-2;P0DPH7-2;P68366-2;P68363;P0DPH8;Q71U36-2;Q71U36;P68366;Q6PEY2;F8VVB9;A0A1W2PQM2;F5H5D3;Q9BQE3;C9JDS9;F8VS66;F8VQQ4;Q9NY65-2;F8VX09;C9JJQ8;C9K0S6;C9JEV8;F8VRZ4;F8VWV9;C9JQ00;Q9NY65;C9J2C0;C9JDL2	TUBA3D	Tubulin alpha-3D chain OS=Homo sapiens OX=9606 GN=TUBA3D PE=1 SV=1	4	4	22								0.892298709	0.103060853	0.145039873	FDR > 0.05	17.43458748	17.58708478	17.53800591	18.1336736	17.7338031	17.84986814	18.25199311	17.97648048	20.78501633	18.02529036
Q01518	480	Q01518-2;Q01518;Q5T0R4;Q5T0R5;Q5T0R1;Q5T0R7;Q5T0R6;Q5T0R2;Q5T0R9;Q5T0R3	CAP1	Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5	4	4	26	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;extracellular;membrane;organelle lumen	protein binding	CAP1	Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling		Platelet degranulation ; Neutrophil degranulation; Role of ABL in ROBO-SLIT signaling	0.37128869	0.090884897	0.13120707	FDR > 0.05	17.73472038	17.79485967	17.81892308	17.96165291	17.92965804	17.82784389	18.12329194	17.86280669	18.96432835	18.31798667
H0Y755	61	H0Y755;P08637	FCGR3A	Low affinity immunoglobulin gamma Fc region receptor III-A OS=Homo sapiens OX=9606 GN=FCGR3A PE=1 SV=3	6	2	52								-0.80533218	4.99e-06	3.26e-05	FDR <= 0.01	21.3241041	21.34110409	21.30767582	21.27322395	21.25974927	20.53703879	20.34253727	20.53639857	20.67358547	20.38963624
I3L145	215	P04278;I3L145;I3L1J1;B4DYU0;P04278-2;A0A0C4DGN2;P04278-4;P04278-3;I3L2X4;B0FWH6;I3L4B9;I3L2F1;B0FWH5;P04278-5;I3L1G4;I3L1C1;B0FWH7	SHBG	Sex hormone-binding globulin OS=Homo sapiens OX=9606 GN=SHBG PE=1 SV=1	5	5	45		extracellular	protein binding	SHBG				-1.349941882	1.51e-06	1.35e-05	FDR <= 0.01	21.19882107	21.19820217	21.26926735	21.19257806	21.03138462	20.14724053	19.75078286	19.63564872	20.10631875	19.50055299
P55103	48	P55103	INHBC	Inhibin beta C chain OS=Homo sapiens OX=9606 GN=INHBC PE=2 SV=1	5	5	25	regulation of biological process;response to stimulus	extracellular	protein binding	INHBC		Cytokine-cytokine receptor interaction; Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway	Glycoprotein hormones	-0.796771171	1.13e-05	6.26e-05	FDR <= 0.01	20.77096574	20.78128728	20.77997863	20.70864527	20.71920083	20.17027716	19.91014005	20.0842359	19.78970992	19.82185885
A0A3B3ISU3	289	A0A087WZR4;O75015;A0A3B3ISU3;H0Y4U3	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B OS=Homo sapiens OX=9606 GN=FCGR3B PE=1 SV=1	6	2	43								-1.175614605	0.001955249	0.004888121	FDR <= 0.01	15.90855566	16.36908102	16.10678895	14.99565219	16.00571102	14.83674388	14.33306498	14.103333	15.32613217	14.90844178
P01706	155	P01706	IGLV2-11	Immunoglobulin lambda variable 2-11 OS=Homo sapiens OX=9606 GN=IGLV2-11 PE=1 SV=2	2	2	107	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV2-11			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.296180283	0.281994826	0.34894732	FDR > 0.05	23.06198057	22.98631407	22.89464678	23.07899428	22.76365683	24.31876525	23.32567915	22.92264739	22.86849239	22.83090976
A0A0B4J1X8	234	A0A0B4J1X8	IGHV3-43	Immunoglobulin heavy variable 3-43 OS=Homo sapiens OX=9606 GN=IGHV3-43 PE=3 SV=1	3	3	108	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-43				0.140693279	0.339983212	0.412405672	FDR > 0.05	21.04132046	21.21419797	21.18886048	21.31716103	21.2360726	21.72216745	21.37237751	21.47085114	21.01374637	21.12193646
P01619	247	P01619	IGKV3-20	Immunoglobulin kappa variable 3-20 OS=Homo sapiens OX=9606 GN=IGKV3-20 PE=1 SV=2	3	1	148	cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV3-20			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.497854031	0.005632721	0.011986586	FDR <= 0.05	17.88017041	18.12526652	18.08782667	17.9804149	18.23655585	18.54653615	18.33128719	18.70305775	18.27033274	18.94829068
I6L8B7	617	I6L8B7;Q01469	FABP5	Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=1	4	4	13	transport		transporter activity		PPAR signaling pathway			0.596236323	0.018012054	0.032773413	FDR <= 0.05	19.20910652	18.52609274	18.88488529	19.00653934	18.61957518	19.32578078	19.84974527	19.51744805	19.75790247	18.77650411
A0A075B7D0	419	A0A075B7D0	IGHV1OR15-1	Immunoglobulin heavy variable 1/OR15-1 (non-functional) (Fragment) OS=Homo sapiens OX=9606 GN=IGHV1OR15-1 PE=1 SV=1	4	3	79	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding					-0.587935361	0.012781271	0.024796472	FDR <= 0.05	22.67070376	22.63977821	22.53230523	22.61581187	22.46559937	22.64986199	22.08471605	22.09438254	21.44374828	21.71181277
A0A0C4DH32	688	A0A0C4DH32	IGHV3-20	Immunoglobulin heavy variable 3-20 OS=Homo sapiens OX=9606 GN=IGHV3-20 PE=3 SV=2	2	2	33	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-20				-0.192816592	0.167779861	0.218149291	FDR > 0.05	20.20923052	20.46598737	20.37079166	20.52196175	20.43626939	20.36801011	20.3803955	20.3743959	19.8652423	20.05211393
P10646-2	544	P10646-2;C9JKV3;P10646;C9JT76;C9JQ14	TFPI	Isoform Beta of Tissue factor pathway inhibitor OS=Homo sapiens OX=9606 GN=TFPI	5	5	20	coagulation;metabolic process;regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;extracellular;membrane	enzyme regulator activity	TFPI	Integrated Breast Cancer Pathway; Complement and Coagulation Cascades			0.63195394	0.016701035	0.030844255	FDR <= 0.05	19.82451706	19.8395151	19.78914547	19.83371268	19.73081978	20.28450966	19.7804613	20.32630024	20.5336897	21.2525189
Q9BTY2	483	Q9BTY2;Q9BTY2-2;Q7Z6V2	FUCA2	Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2	6	6	28	metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	catalytic activity;protein binding	FUCA2		Other glycan degradation	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation	-1.601498877	1.78e-06	1.56e-05	FDR <= 0.01	19.27474437	19.23271012	19.1912626	19.23282548	19.23994548	17.66264897	17.43964102	17.32192778	18.28855144	17.45122445
P08253	546	P08253-2;P08253-3;P08253;H3BR66;H3BV48	MMP2	72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2	4	4	13	cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane;mitochondrion;nucleus	catalytic activity;metal ion binding;protein binding	MMP2	Matrix Metalloproteinases; AGE/RAGE pathway; Photodynamic therapy-induced NF-kB survival signaling; Lung fibrosis; VEGFA-VEGFR2 Signaling Pathway	Estrogen signaling pathway; Bladder cancer; AGE-RAGE signaling pathway in diabetic complications; GnRH signaling pathway; Leukocyte transendothelial migration; Pathways in cancer; Endocrine resistance; Proteoglycans in cancer	Collagen degradation; EPH-ephrin mediated repulsion of cells; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Activation of Matrix Metalloproteinases; Interleukin-4 and 13 signaling	-1.55387537	3.53e-07	5.43e-06	FDR <= 0.01	17.49687609	17.68920199	17.67760743	17.59941988	17.60816863	15.9152756	15.9786615	15.96471845	16.56706357	15.87617803
A0A0C4DH72	239	A0A0C4DH72	IGKV1-6	Immunoglobulin kappa variable 1-6 OS=Homo sapiens OX=9606 GN=IGKV1-6 PE=3 SV=1	2	1	35	response to stimulus	extracellular;membrane		IGKV1-6				0.316561592	0.059508165	0.092185193	FDR > 0.05	19.82477615	19.90216479	19.69570527	19.84120031	19.75617503	20.61925808	19.88421376	19.83102915	20.04539574	20.22293277
P01717	559	P01717	IGLV3-25	Immunoglobulin lambda variable 3-25 OS=Homo sapiens OX=9606 GN=IGLV3-25 PE=1 SV=2	3	1	56	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV3-25			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.045210896	0.884677594	0.900789272	FDR > 0.05	16.63091452	16.96818951	16.79179428	16.82708604	17.24982466	17.3328916	15.73356311	16.94858834	17.07090744	17.60791299
O95497	380	O95497	VNN1	Pantetheinase OS=Homo sapiens OX=9606 GN=VNN1 PE=1 SV=2	5	5	22	cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	VNN1		Pantothenate and CoA biosynthesis	Vitamin B5 (pantothenate) metabolism; Neutrophil degranulation; Post-translational modification: synthesis of GPI-anchored proteins	-0.941658002	3.85e-06	2.76e-05	FDR <= 0.01	19.75293928	19.72532719	19.68245369	19.7018561	19.7183083	18.50256295	18.78565854	18.73395542	19.02887676	18.82154088
P04792	142	P04792;A0A6Q8PFK8;A0A6Q8PGK1;A0A6Q8PHJ6;A0A6Q8PFE7;A0A6Q8PF43;A0A6Q8PH65;A0A6Q8PHA6;A0A6Q8PGY2;C9J3N8	HSPB1	Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2	5	5	24	cellular component movement;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane;nucleus;proteasome	enzyme regulator activity;protein binding;RNA binding	HSPB1	Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; MAPK Signaling Pathway; ATM Signaling Network in Development and Disease; VEGFA-VEGFR2 Signaling Pathway; p38 MAPK Signaling Pathway	Epstein-Barr virus infection; MAPK signaling pathway; Amoebiasis; VEGF signaling pathway	AUF1 (hnRNP D0) binds and destabilizes mRNA; VEGFA-VEGFR2 Pathway; MAPK6/MAPK4 signaling	0.711653234	0.075989341	0.112340011	FDR > 0.05	18.7154372	18.64577047	18.6123751	19.77270943	18.46469162	19.12953467	19.64148396	19.59341814	20.69221634	18.7125969
Q9UNW1	732	Q9UNW1;Q9UNW1-4;Q9UNW1-2;Q9UNW1-3	MINPP1	Multiple inositol polyphosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=MINPP1 PE=1 SV=1	5	5	20	metabolic process	endoplasmic reticulum;organelle lumen	catalytic activity	MINPP1		Glycolysis / Gluconeogenesis; Metabolic pathways; Inositol phosphate metabolism	Synthesis of IPs in the ER lumen	-1.013571519	1.58e-05	8.29e-05	FDR <= 0.01	18.84009299	18.79647459	18.75352738	18.87291004	18.63278904	17.56411489	17.89906428	17.71454105	18.15787268	17.49234355
P13497	310	P13497;P13497-2;P13497-6;P13497-5;P13497-4;O43897;Q9Y6L7;E9PD25	BMP1	Bone morphogenetic protein 1 OS=Homo sapiens OX=9606 GN=BMP1 PE=1 SV=2	6	6	28	cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process	extracellular;Golgi	catalytic activity;metal ion binding;protein binding	BMP1	Adipogenesis; Cardiac Progenitor Differentiation; Canonical and Non-Canonical TGF-B signaling; EDA Signalling in Hair Follicle Development		Anchoring fibril formation; Degradation of the extracellular matrix; Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	0.313311719	0.068755175	0.103638315	FDR > 0.05	18.11876332	18.19677242	18.24123594	18.33759539	18.15185407	18.32445862	18.28087409	18.72319387	18.27330579	19.01094738
P10599	625	P10599-2;P10599	TXN	Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3	3	3	25	cell communication;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;mitochondrion;nucleus	antioxidant activity;catalytic activity;protein binding;RNA binding	TXN	Selenium Micronutrient Network; TNF alpha Signaling Pathway; NRF2 pathway; VEGFA-VEGFR2 Signaling Pathway	NOD-like receptor signaling pathway	Interconversion of nucleotide di- and triphosphates; Protein repair; TP53 Regulates Metabolic Genes; The NLRP3 inflammasome; Oxidative Stress Induced Senescence; Detoxification of Reactive Oxygen Species	0.66527573	0.013894412	0.026620135	FDR <= 0.05	20.64951722	20.34700522	20.25440187	20.78883391	20.24134656	20.69096823	21.4947054	21.25036433	21.63304649	20.53839897
A0A0C4DGZ8	97	P07359;A0A0C4DGZ8	GP1BA	Glycoprotein Ib (Platelet), alpha polypeptide OS=Homo sapiens OX=9606 GN=GP1BA PE=1 SV=1	5	5	21	cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;membrane	enzyme regulator activity;protein binding;receptor activity;signal transducer activity	GP1BA				-1.438653867	7.32e-07	8.04e-06	FDR <= 0.01	19.97306886	20.03928638	19.92959326	20.03131827	19.95109378	18.62657661	18.39762431	18.18625205	18.97178462	18.54885362
A0A0C4DH33	541	A0A0C4DH33	IGHV1-24	Immunoglobulin heavy variable 1-24 OS=Homo sapiens OX=9606 GN=IGHV1-24 PE=3 SV=1	3	2	19	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV1-24				0.736985765	0.001758172	0.004431458	FDR <= 0.01	16.64120012	17.34102223	17.30424189	17.2220879	17.63331015	18.04435938	18.23163356	17.94484246	17.72006232	17.8858934
Q5SR44	19	E9PQN4;E9PDY4;P17927;Q5SR44;H0YE06	CR1	Complement receptor type 1 OS=Homo sapiens OX=9606 GN=CR1 PE=1 SV=1	3	3	14	defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;membrane	protein binding;receptor activity;signal transducer activity	CR1	Primary Focal Segmental Glomerulosclerosis FSGS; Complement and Coagulation Cascades			1.158115238	0.003609973	0.008222717	FDR <= 0.01	16.83364787	17.22699292	17.13668338	17.07057373	17.19774571	17.97072108	19.60030078	17.89069267	17.77465162	18.01985366
A0A087WSY4	318	A0A087WSY4	IGHV4-30-2	Immunoglobulin heavy variable 4-30-2 OS=Homo sapiens OX=9606 GN=IGHV4-30-2 PE=3 SV=1	2	1	96	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV4-31				0.161141143	0.269741736	0.335133672	FDR > 0.05	19.53885354	19.83793776	19.75848044	19.67489862	19.79471668	19.95920668	19.78140145	19.88774055	19.52466471	20.25757936
Q5QNW6	153	O60814;U3KQK0;Q5QNW6;P57053;Q93079;P62807;Q99877;Q5QNW6-2;P58876;Q99879;Q99880;P23527;Q16778;P06899;P33778;Q8N257;Q96A08;A0A2R8Y619	H2BC18	Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3	5	5	43	cell organization and biogenesis	chromosome;cytosol;nucleus	DNA binding;protein binding	HIST2H2BF		Alcoholism; Viral carcinogenesis; Systemic lupus erythematosus	HDACs deacetylate histones; HATs acetylate histones; Ub-specific processing proteases	0.457575732	0.485799315	0.553534533	FDR > 0.05	19.44901424	19.80336972	19.41702145	20.2340589	21.19262927	19.84470834	19.73268686	20.1141733	23.03881793	19.65358581
A0A075B6K6	690	A0A075B6K6	IGLV4-3	Immunoglobulin lambda variable 4-3 OS=Homo sapiens OX=9606 GN=IGLV4-3 PE=3 SV=1	3	3	30	response to stimulus	extracellular;membrane		IGLV4-3				1.19492357	9.31e-05	0.00034925	FDR <= 0.01	21.67169982	21.66926162	21.47873068	21.70389251	21.37174085	22.97166726	23.33934617	22.13740794	22.68364778	22.73787418
A0A087WW87	3	A0A087X0Q4;A0A087WW87	IGKV2-40	Immunoglobulin kappa variable 2-40 OS=Homo sapiens OX=9606 GN=IGKV2-40 PE=3 SV=2	3	1	181	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV2-40; IGKV2D-40			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.462169838	0.0225013	0.03931335	FDR <= 0.05	15.34001649	15.03163468	15.11730207	15.29508436	15.39166236	15.93762364	16.15992676	15.66562591	15.49677487	15.22659797
Q6EMK4	395	Q6EMK4	VASN	Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1	4	4	21	regulation of biological process;response to stimulus	cell surface;extracellular;membrane;mitochondrion	protein binding	VASN				-0.513528027	0.10625004	0.147170663	FDR > 0.05	17.85243816	17.65138771	17.62725023	17.77739377	17.49628033	16.66901603	18.30031613	17.28503109	17.0854972	16.49724961
A0A0A0MRZ9	127	A0A0A0MRZ9	IGLV5-52	Immunoglobulin lambda variable 5-52 OS=Homo sapiens OX=9606 GN=IGLV5-52 PE=3 SV=1	3	3	23	response to stimulus	extracellular;membrane		IGLV5-52				1.41181854	0.000671149	0.00191091	FDR <= 0.01	18.3633901	18.70131937	18.63612471	18.52137327	18.59898011	20.39746888	19.1664914	20.97521153	19.4473156	19.89379286
H0YN67	87	H0YN67;H0YL90;O14498	ISLR	Immunoglobulin superfamily-containing leucine-rich repeat protein (Fragment) OS=Homo sapiens OX=9606 GN=ISLR PE=1 SV=1	3	3	12			protein binding					-0.825367028	2.2e-05	0.000106506	FDR <= 0.01	18.84334019	18.9141954	18.74845641	18.85992965	18.80379721	18.18314468	17.7288576	17.90059791	18.2276701	18.00261343
G3V0E5	27	G3V0E5;P02786	TFRC	Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=1	3	3	12	cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;endosome;extracellular;membrane	protein binding;receptor activity;RNA binding;transporter activity	TFRC	Iron metabolism in placenta			-0.282027417	0.078238446	0.115111589	FDR > 0.05	17.71522609	17.74520188	17.76056476	17.71068611	17.69416638	17.58203157	16.94951693	17.33412783	17.63634385	17.71368794
Q9H4G4	144	Q9H4G4;Q5VZR0;A0A087WUM5	GLIPR2	Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens OX=9606 GN=GLIPR2 PE=1 SV=3	4	4	21	regulation of biological process	extracellular;Golgi;membrane	protein binding	GLIPR2				-0.311680155	0.005557313	0.011867178	FDR <= 0.05	18.81022016	18.67366672	18.58672022	18.72192267	18.72280773	18.38478318	18.42414853	18.32137196	18.33095893	18.49567412
P18206	116	P18206-2;P18206;P18206-3	VCL	Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4	6	6	31	cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen	protein binding;structural molecule activity	VCL	Integrin-mediated Cell Adhesion; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton	Bacterial invasion of epithelial cells; Adherens junction; Leukocyte transendothelial migration; Focal adhesion; Shigellosis; Regulation of actin cytoskeleton; Amoebiasis	Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-20 family signaling	0.534677285	0.000502941	0.001465918	FDR <= 0.01	18.89482641	18.92467437	18.92476341	18.93066962	18.8951592	19.27663304	19.52916383	19.25140475	19.70979955	19.47647827
A0A0J9YX35	423	A0A0J9YX35	IGHV3-64D	Immunoglobulin heavy variable 3-64D OS=Homo sapiens OX=9606 GN=IGHV3-64D PE=3 SV=1	3	2	18	response to stimulus	extracellular;membrane	catalytic activity	IGHV3-64D				0.40809022	0.127073483	0.170261856	FDR > 0.05	19.81358052	19.7941722	19.78963223	19.74039714	19.74246247	20.36875411	20.14930473	21.0694728	19.45952988	19.87363414
P29508	134	P29508-2;P29508	SERPINB3	Serpin B3 OS=Homo sapiens OX=9606 GN=SERPINB3 PE=1 SV=2	6	4	27	cell communication;regulation of biological process;transport	cytoplasm;extracellular;nucleus;organelle lumen	enzyme regulator activity;protein binding;receptor activity	SERPINB3		Amoebiasis	Neutrophil degranulation	0.822604238	0.129386346	0.172983919	FDR > 0.05	20.15029356	20.32800122	20.30548012	20.67751752	19.76230498	20.1399304	21.7218631	20.85123039	22.82485191	19.79874279
Q9UEW3	387	Q9UEW3;Q9UEW3-2	MARCO	Macrophage receptor MARCO OS=Homo sapiens OX=9606 GN=MARCO PE=1 SV=1	4	4	20	defense response;regulation of biological process;response to stimulus;transport	membrane	protein binding;receptor activity;signal transducer activity	MARCO		Phagosome	Scavenging by Class A Receptors	0.634541187	0.007445473	0.015417394	FDR <= 0.05	16.89904752	16.89578536	16.9678156	16.86219519	17.07472904	16.90123119	17.54073703	17.81098446	17.52202431	18.09730165
A0A0A0MSN4	494	P12821;P12821-3;F6X3S4;A0A0A0MSN4;P12821-4;P12821-2	ACE	Angiotensin-converting enzyme OS=Homo sapiens OX=9606 GN=ACE PE=1 SV=1	5	5	20	metabolic process	membrane	catalytic activity;metal ion binding					-1.087731014	2.67e-06	2.08e-05	FDR <= 0.01	19.48937779	19.50067449	19.44291877	19.41817423	19.38245238	18.39595868	18.40808487	18.15675518	18.69780831	18.13633556
Q86UD1	343	Q86UD1;E9PJ29	OAF	Out at first protein homolog OS=Homo sapiens OX=9606 GN=OAF PE=2 SV=1	4	4	16				OAF				-1.283093742	4.74e-07	6.43e-06	FDR <= 0.01	19.52837668	19.51436296	19.44191559	19.46530948	19.36469368	18.18260365	18.28781031	17.97090627	18.48479763	17.97307183
P48594	56	P48594;H0Y5H9;C9JZ65	SERPINB4	Serpin B4 OS=Homo sapiens OX=9606 GN=SERPINB4 PE=1 SV=2	5	3	28	regulation of biological process	cytoplasm	enzyme regulator activity;protein binding	SERPINB4		Amoebiasis		1.193089784	0.041511459	0.067183019	FDR > 0.05	16.68967279	16.88052163	16.9582629	17.41624858	17.11585895	17.46388845	18.27284234	17.62345933	20.39520773	17.27061592
A8K2U0	493	A8K2U0;H0YGG5;A8K2U0-2	A2ML1	Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens OX=9606 GN=A2ML1 PE=1 SV=3	4	4	20	regulation of biological process	extracellular	enzyme regulator activity	A2ML1				0.771471047	0.016547716	0.030653149	FDR <= 0.05	17.53811781	17.74861117	17.8880181	18.3573445	17.57494603	18.21588103	19.09398715	18.54938096	19.24212827	17.86301543
P49913	392	J3KNB4;P49913	CAMP	Cathelicidin antimicrobial peptide OS=Homo sapiens OX=9606 GN=CAMP PE=1 SV=1	5	5	28	defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	CAMP	Sterol Regulatory Element-Binding Proteins (SREBP) signalling	NOD-like receptor signaling pathway; Tuberculosis; Salivary secretion	Antimicrobial peptides; Neutrophil degranulation	0.8376503	3.44e-05	0.000153407	FDR <= 0.01	21.90180782	21.80112983	21.72111689	21.75774653	21.68831233	22.80059071	22.4433452	22.56791236	22.35949135	22.88702528
A0A0D9SEN1	430	A0A0D9SEN1;B4DLR2;Q12884;C9J131	FAP	Prolyl endopeptidase FAP OS=Homo sapiens OX=9606 GN=FAP PE=1 SV=1	5	5	21	metabolic process		catalytic activity					-0.027319758	0.868390898	0.888619638	FDR > 0.05	17.14177619	17.58876215	17.45775999	17.62981509	17.51280416	17.8708702	17.19360979	17.38185753	17.13733304	17.61064821
P31946	120	P31946;P31946-2;E7EX29;P27348;P63104;Q4VY20;A0A0J9YWE8;Q4VY19;A0A0J9YWZ2;H0YB80;P63104-2;B0AZS6;B7Z2E6	YWHAB	14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3	5	2	32	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane;mitochondrion;nucleus	protein binding	YWHAB	Cell Cycle; IL-3 Signaling Pathway; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	PI3K-Akt signaling pathway; Hippo signaling pathway; Viral carcinogenesis; Cell cycle; Epstein-Barr virus infection; Oocyte meiosis; Hepatitis B	MAP2K and MAPK activation; mTORC1-mediated signalling; Negative regulation of MAPK pathway; ARMS-mediated activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Interleukin-20 family signaling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by BRAF and RAF fusions; Signaling by Hippo; Activation of BAD and translocation to mitochondria ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; TP53 Regulates Metabolic Genes; RAF activation; RHO GTPases activate PKNs	0.771960964	0.003609334	0.008222717	FDR <= 0.01	14.44521398	14.19790774	14.52593597	14.60151608	14.55231786	15.29463158	15.06198364	15.07509432	15.99861972	14.75236718
K7ES25	202	K7ES25;A0A494C165;P12955;P12955-3;P12955-2;A0A494C194	PEPD	Xaa-Pro dipeptidase (Fragment) OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3	4	4	25								-0.802973858	0.000348731	0.001122877	FDR <= 0.01	20.28544988	20.27850433	20.21393066	20.24297736	20.13356213	19.07107302	19.85664955	19.10320291	19.62535872	19.48327087
O95428	162	O95428-6;O95428-5;O95428;O95428-4;B5MDP7;G3V5P6	PAPLN	Papilin OS=Homo sapiens OX=9606 GN=PAPLN PE=2 SV=4	4	4	14	metabolic process;regulation of biological process	extracellular	catalytic activity;enzyme regulator activity;metal ion binding;protein binding	PAPLN				-0.361848035	0.021490422	0.037761741	FDR <= 0.05	17.02539485	17.17476974	17.06190278	17.21560295	16.9103226	16.53390815	16.53618757	16.90743231	16.54037475	17.06084997
Q13332	731	Q13332;Q13332-3;Q13332-6;Q13332-2;Q13332-4	PTPRS	Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3	3	3	10	metabolic process;regulation of biological process	membrane	catalytic activity;protein binding	PTPRS			ECM proteoglycans; Receptor-type tyrosine-protein phosphatases; Synaptic adhesion-like molecules	0.55143927	0.003647728	0.008278055	FDR <= 0.01	17.21519924	17.26493544	17.27482744	17.20569919	17.24499329	17.41002283	18.23417075	17.97883689	17.73565143	17.60416906
P68104	398	Q5VTE0;P68104;Q05639;A0A2U3TZH3;A0A7I2V3H3;A0A7I2V5N4;A0A087WV01;A0A7I2V659;A0A087WVQ9;A0A2R8Y488;A0A2R8Y660;Q5JR01;A6PW80	EEF1A1	Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1	4	4	23	metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding	EEF1A1	Translation Factors	RNA transport; Legionellosis	Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation	0.644747597	0.113837482	0.156272436	FDR > 0.05	18.16945269	17.92650736	17.86620453	18.98697724	17.94948018	18.60728121	18.57619584	18.95429787	20.10987626	17.87470882
Q8WUJ3	479	Q8WUJ3;Q8WUJ3-2	CEMIP	Cell migration-inducing and hyaluronan-binding protein OS=Homo sapiens OX=9606 GN=CEMIP PE=1 SV=2	5	5	24	metabolic process;regulation of biological process	cytoplasm;endoplasmic reticulum;extracellular;membrane;nucleus	catalytic activity;protein binding	KIAA1199; CEMIP			Hyaluronan biosynthesis and export	0.752124997	8.08e-05	0.000312473	FDR <= 0.01	16.61330027	16.61261174	16.66176649	16.73688097	16.64711793	17.57466206	17.07293353	17.5165961	17.25772389	17.61038681
P43121	66	P43121;P43121-2	MCAM	Cell surface glycoprotein MUC18 OS=Homo sapiens OX=9606 GN=MCAM PE=1 SV=2	4	4	16	regulation of biological process	extracellular;membrane;nucleus	protein binding	MCAM				-1.071699721	3.99e-06	2.79e-05	FDR <= 0.01	18.48823113	18.42788085	18.41882484	18.43306519	18.29189042	17.42254865	17.47238921	17.27449643	17.56614901	16.96581052
P01718	143	P01718	IGLV3-27	Immunoglobulin lambda variable 3-27 OS=Homo sapiens OX=9606 GN=IGLV3-27 PE=1 SV=2	3	2	51	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV3-27			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	-0.090527772	0.624240763	0.672343379	FDR > 0.05	21.91712673	21.82412714	21.68478233	21.74927163	21.65739397	22.34821336	21.27862274	21.52273164	21.58826982	21.64222537
Q92743	485	Q92743;A0A3B3IU24	HTRA1	Serine protease HTRA1 OS=Homo sapiens OX=9606 GN=HTRA1 PE=1 SV=1	4	4	20	cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process	cytoplasm;cytosol;extracellular;membrane	catalytic activity;protein binding	HTRA1			Degradation of the extracellular matrix	-0.17486669	0.118701618	0.161151203	FDR > 0.05	15.57852102	15.74991341	15.57933417	15.64700889	15.79060688	15.48221901	15.6273901	15.34335049	15.3766315	15.64145982
Q96RW7	332	Q96RW7;Q96RW7-2	HMCN1	Hemicentin-1 OS=Homo sapiens OX=9606 GN=HMCN1 PE=1 SV=2	5	5	19	cell division;response to stimulus	cell surface;cytoplasm;extracellular;membrane	metal ion binding;protein binding	HMCN1				0.258043597	0.133755145	0.178436907	FDR > 0.05	17.15113637	17.32623013	17.22082695	17.24098356	17.24599398	17.30426902	17.35465591	17.93924449	17.10150066	17.77571891
Q15848	631	Q15848	ADIPOQ	Adiponectin OS=Homo sapiens OX=9606 GN=ADIPOQ PE=1 SV=1	3	3	64	cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;extracellular	protein binding	ADIPOQ	AMP-activated Protein Kinase (AMPK) Signaling; Type II diabetes mellitus; Adipogenesis; Differentiation of white and brown adipocyte; Transcription factor regulation in adipogenesis; Leptin and adiponectin; PPAR signaling pathway	Adipocytokine signaling pathway; Type II diabetes mellitus; Longevity regulating pathway; AMPK signaling pathway; Non-alcoholic fatty liver disease (NAFLD); PPAR signaling pathway	Transcriptional regulation of white adipocyte differentiation; AMPK inhibits chREBP transcriptional activation activity	0.825385824	0.000255083	0.000852586	FDR <= 0.01	21.27892692	21.30067271	21.16156233	21.24759483	21.06743928	22.21119569	22.00429854	21.52227904	22.05510511	22.39024679
A0A0B4J1V1	334	A0A0B4J1V1	IGHV3-21	Immunoglobulin heavy variable 3-21 OS=Homo sapiens OX=9606 GN=IGHV3-21 PE=1 SV=1	3	2	56	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-21				0.67972427	0.000269785	0.00088726	FDR <= 0.01	19.67810848	19.84985167	19.7705108	19.84876419	19.86950874	20.65089283	20.80761531	20.3892466	20.19425893	20.37335154
P02747	47	P02747	C1QC	Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3	4	4	78	defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	catalytic activity;protein binding	C1QC	Allograft Rejection; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage; TYROBP Causal Network; Complement Activation; Complement and Coagulation Cascades	Pertussis; Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection	Regulation of Complement cascade; Classical antibody-mediated complement activation	1.862175762	3.77e-08	2.44e-06	FDR <= 0.01	24.45453833	24.25935907	24.31624994	24.38096543	24.27298429	26.4481188	26.20797479	26.03587163	25.84418584	26.45882479
P17936	161	P17936;A6XND0;P17936-2;A6XND1;H0Y5K2;B3KWK7;C9JMX4;H0Y485	IGFBP3	Insulin-like growth factor-binding protein 3 OS=Homo sapiens OX=9606 GN=IGFBP3 PE=1 SV=2	5	5	17	cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process	extracellular;nucleus;organelle lumen	enzyme regulator activity;metal ion binding;protein binding	IGFBP3	Myometrial Relaxation and Contraction Pathways; Photodynamic therapy-induced HIF-1 survival signaling; Senescence and Autophagy in Cancer	p53 signaling pathway; Transcriptional misregulation in cancer	TP53 Regulates Transcription of Death Receptors and Ligands; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-0.329603932	0.020935121	0.037104033	FDR <= 0.05	19.81195108	19.90501676	19.82583119	19.84583345	19.77754656	19.35635309	19.8323225	19.25401272	19.64307925	19.43239183
P01040	482	P01040;C9J0E4	CSTA	Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1	4	4	10	cell death;cell differentiation;metabolic process;regulation of biological process	cytoplasm;cytoskeleton;cytosol	enzyme regulator activity;protein binding;structural molecule activity	CSTA			Formation of the cornified envelope	0.452467653	0.063242444	0.096751501	FDR > 0.05	19.66201599	19.78702067	19.76624253	19.97183585	19.62679267	19.88416648	21.02483433	20.36506159	20.03779586	19.76438772
Q5VY30	259	Q5VY30;P02753	RBP4	Retinol-binding protein OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=2	4	4	35	metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular	protein binding;transporter activity	RBP4	Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Vitamin A and Carotenoid Metabolism			-0.547457915	0.008890656	0.017927061	FDR <= 0.05	20.43910693	20.60521344	20.58927585	20.62207658	20.59280778	19.95179338	19.40718264	20.33124642	20.06986471	20.35110386
Q9NPG4	671	Q9NPG4	PCDH12	Protocadherin-12 OS=Homo sapiens OX=9606 GN=PCDH12 PE=1 SV=1	4	4	28	cell communication;metabolic process	membrane	metal ion binding	PCDH12				0.810492436	8.2e-05	0.000315182	FDR <= 0.01	18.58705962	18.79620866	18.74290054	18.71751436	18.75456964	19.35846205	19.966998	19.32553466	19.47267034	19.52704994
A0A075B6K5	402	A0A075B6K5;P80748	IGLV3-9	Immunoglobulin lambda variable 3-9 OS=Homo sapiens OX=9606 GN=IGLV3-9 PE=3 SV=1	3	3	37	response to stimulus	extracellular;membrane		IGLV3-9				0.118556102	0.399426257	0.472398361	FDR > 0.05	21.44272649	21.35986352	21.43934825	21.43812124	21.24466669	21.84733919	21.13905751	21.62883857	21.36515713	21.53711429
Q9UBQ6	661	Q9UBQ6;F5GZK1;C9JEG3;C9IYF5	EXTL2	Exostosin-like 2 OS=Homo sapiens OX=9606 GN=EXTL2 PE=1 SV=1	4	4	16	metabolic process	endoplasmic reticulum;extracellular;membrane	catalytic activity;metal ion binding	EXTL2		Metabolic pathways; Glycosaminoglycan biosynthesis - heparan sulfate / heparin	XBP1(S) activates chaperone genes	-1.433996377	7.78e-05	0.000304376	FDR <= 0.01	18.15606671	18.19523067	18.21778205	18.15984452	18.36955026	16.68858258	16.3827555	16.15202998	17.31963034	17.38549392
A0A669KBE7	286	Q6UY14;A0A669KBE7;Q6UY14-3;Q6UY14-2	ADAMTSL4	ADAMTS-like protein 4 OS=Homo sapiens OX=9606 GN=ADAMTSL4 PE=1 SV=1	3	3	12								-1.689992518	1.93e-05	9.72e-05	FDR <= 0.01	17.99766452	17.76980099	17.81274748	17.94856587	17.78827765	16.03601424	15.661733	16.99119231	16.44718543	15.73096895
A0A075B6J9	600	A0A075B6J9	IGLV2-18	Immunoglobulin lambda variable 2-18 OS=Homo sapiens OX=9606 GN=IGLV2-18 PE=3 SV=2	2	2	19	response to stimulus	extracellular;membrane		IGLV2-18				0.252726449	0.102423932	0.144474124	FDR > 0.05	21.02789881	20.89693073	21.18137384	21.05453932	21.20238912	21.79738379	21.08394149	21.2477452	21.28309055	21.21460302
E9PGA6	460	Q9BXJ4;E9PGA6;Q9BXJ4-3;Q9BXJ4-2	C1QTNF3-AMACR	C1QTNF3-AMACR readthrough (NMD candidate) OS=Homo sapiens OX=9606 GN=C1QTNF3-AMACR PE=4 SV=1	3	3	18		extracellular	protein binding					1.215942147	0.00288773	0.00701958	FDR <= 0.01	18.88204015	18.87269601	18.88324814	19.04059914	18.99951038	20.3353006	21.44928783	19.6078944	19.64355602	19.72176571
P40189	149	P40189;A0A494BZU0;P40189-3	IL6ST	Interleukin-6 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL6ST PE=1 SV=2	4	4	15	metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding;receptor activity;signal transducer activity	IL6ST	Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Interleukin-11 Signaling Pathway; Adipogenesis; Oncostatin M Signaling Pathway; IL-6 signaling pathway; ESC Pluripotency Pathways; Senescence and Autophagy in Cancer	Cytokine-cytokine receptor interaction; Signaling pathways regulating pluripotency of stem cells; Jak-STAT signaling pathway; Viral carcinogenesis	IL-6-type cytokine receptor ligand interactions; MAPK3 (ERK1) activation; Interleukin-35 Signalling; MAPK1 (ERK2) activation; Interleukin-20 family signaling	-0.481932803	0.002237919	0.005549677	FDR <= 0.01	17.22389294	17.55057871	17.30070845	17.55975085	17.45515564	17.19549172	16.70966295	16.98369102	16.93555619	16.85602071
P03950	455	P03950	ANG	Angiogenin OS=Homo sapiens OX=9606 GN=ANG PE=1 SV=1	3	3	16	cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus	extracellular;nucleus	catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding	ANG			Adherens junctions interactions	-1.15611204	4.59e-06	3.13e-05	FDR <= 0.01	18.70872653	18.59514363	18.62725393	18.68770008	18.59744329	17.50331554	17.23833682	17.31564572	17.95178895	17.42662022
Q8IUK5	185	Q8IUK5;B4E173;Q8IUK5-2;Q8IUK5-3;Q8IUK5-4	PLXDC1	Plexin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PLXDC1 PE=1 SV=2	4	3	23		cytoplasm;extracellular;membrane	protein binding	PLXDC1				-0.128240363	0.429452592	0.503073036	FDR > 0.05	15.00414063	14.97072809	14.77110541	15.4663878	14.83470325	15.2322791	14.88487	14.83578369	14.79102258	14.661908
Q8IXL6	717	Q8IXL6;Q8IXL6-2	FAM20C	Extracellular serine/threonine protein kinase FAM20C OS=Homo sapiens OX=9606 GN=FAM20C PE=1 SV=2	3	3	13	cell differentiation;metabolic process;regulation of biological process	cytoplasm;extracellular;Golgi;organelle lumen	catalytic activity;metal ion binding;nucleotide binding;protein binding	FAM20C			Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.289801981	0.035263878	0.05893284	FDR > 0.05	16.5022569	16.52057038	16.56420211	16.67387063	16.61035863	17.18398329	16.64924896	16.69303381	16.80636997	16.98763252
Q8TER0	10	Q8TER0-5;Q8TER0;Q8TER0-4;Q8TER0-3;B5MEF5	SNED1	Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNED1 PE=2 SV=2	4	4	17		extracellular	metal ion binding;protein binding	SNED1				0.892803859	6.03e-05	0.000245556	FDR <= 0.01	18.20090515	18.64721225	18.56554897	18.64417838	18.47683217	19.35310484	19.77403406	19.3809379	19.13809967	19.35251975
Q9Y240	240	Q9Y240;V9H0X6;M0R081	CLEC11A	C-type lectin domain family 11 member A OS=Homo sapiens OX=9606 GN=CLEC11A PE=1 SV=1	4	4	18	regulation of biological process	cytoplasm;extracellular	protein binding	CLEC11A				0.620442822	0.0349044	0.058491024	FDR > 0.05	15.41497075	15.69877431	15.32457792	15.30660537	15.7405363	16.22789542	15.49349988	16.33581073	15.5890387	16.94143404
P61769	293	P61769;H0YLF3;F5H6I0	B2M	Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1	4	4	33	cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytosol;extracellular;Golgi;membrane;organelle lumen	protein binding	B2M		Antigen processing and presentation	DAP12 signaling; Neutrophil degranulation; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Amyloid fiber formation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression	-1.403345963	5.15e-07	6.6e-06	FDR <= 0.01	21.64581206	21.39281839	21.36016769	21.39109847	21.27636096	19.87330963	19.99162528	19.78959235	20.39109482	20.00390568
A0A0G2JRQ6	588	A0A0G2JRQ6		Ig-like domain-containing protein (Fragment) OS=Homo sapiens OX=9606 PE=1 SV=4	3	3	48	response to stimulus							0.029850763	0.940575164	0.954544103	FDR > 0.05	22.23972277	22.07413594	22.05912113	22.07449451	21.98083113	21.88331441	22.89159936	23.36396894	21.09043415	21.34824244
P24592	114	P24592;F8VYK9;A0A3B3IUE0	IGFBP6	Insulin-like growth factor-binding protein 6 OS=Homo sapiens OX=9606 GN=IGFBP6 PE=1 SV=1	3	3	13	metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular;Golgi	protein binding	IGFBP6	Myometrial Relaxation and Contraction Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.246913236	0.014883429	0.027991771	FDR <= 0.05	17.57101157	17.59179924	17.56745382	17.67981204	17.5481743	17.83830609	17.93562241	17.81660709	17.77599402	17.82628753
P02775	729	P02775	PPBP	Platelet basic protein OS=Homo sapiens OX=9606 GN=PPBP PE=1 SV=3	4	4	20	cellular component movement;defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding;transporter activity	PPBP	Chemokine signaling pathway	Cytokine-cytokine receptor interaction; Chemokine signaling pathway	Platelet degranulation ; Neutrophil degranulation; Chemokine receptors bind chemokines; G alpha (i) signalling events	1.458388937	0.000236119	0.000793515	FDR <= 0.01	19.15852679	19.13302965	19.04739344	19.10449586	19.05790985	20.62798417	19.59064157	21.20603273	20.2674232	21.1012186
P55290	388	P55290-4;P55290;P55290-5	CDH13	Cadherin-13 OS=Homo sapiens OX=9606 GN=CDH13 PE=1 SV=1	5	5	21	cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane	metal ion binding;protein binding	CDH13			Adherens junctions interactions	-1.530638593	3.74e-08	2.44e-06	FDR <= 0.01	19.30432617	19.27966205	19.30191621	19.31297461	19.30923921	17.62404174	17.59524112	17.73898886	18.0834839	17.81316967
A0A0C4DH34	386	A0A0C4DH34	IGHV4-28	Immunoglobulin heavy variable 4-28 OS=Homo sapiens OX=9606 GN=IGHV4-28 PE=3 SV=1	2	2	163	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV4-28				-0.33692819	0.019811091	0.035625207	FDR <= 0.05	22.83336653	22.97041967	22.85255165	23.007708	22.69130082	22.61151638	22.36396273	22.82294026	22.30650104	22.5657853
A0A075B7D8	648	A0A075B7D8	IGHV3OR15-7	Immunoglobulin heavy variable 3/OR15-7 (pseudogene) (Fragment) OS=Homo sapiens OX=9606 GN=IGHV3OR15-7 PE=1 SV=1	3	2	45	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding					0.739038342	0.000388427	0.001212603	FDR <= 0.01	18.16336001	18.28822465	18.30344638	18.23399143	18.22538655	18.82420672	18.69289047	19.39182447	18.7751273	19.22555177
A0A2R8Y6G6	434	P06733-2;P06733;A0A2R8Y6G6	ENO1	2-phospho-D-glycerate hydro-lyase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=1	4	4	13								0.23438756	0.506680114	0.56966777	FDR > 0.05	19.67543269	19.61538966	19.55710921	19.76217454	19.73702467	19.31664428	19.84175031	19.64944178	21.37258807	19.33864413
Q8JIG5	407	Q8JIG5	ogchi	Alpha-1-acid glycoprotein OS=Gallus gallus OX=9031 GN=ogchi PE=2 SV=1	4	4	46	regulation of biological process;transport	extracellular		OGCHI; ORM1			Platelet degranulation ; Neutrophil degranulation	1.653101889	0.016234076	0.030163011	FDR <= 0.05	18.21174431	21.57835656	21.32184322	21.48801227	21.37240696	22.46784553	22.93664422	22.25204885	22.15975715	22.42157703
P49908	379	P49908;A0A182DWH7	SELENOP	Selenoprotein P OS=Homo sapiens OX=9606 GN=SELENOP PE=1 SV=3	4	4	33	metabolic process;reproduction;response to stimulus;transport	extracellular;organelle lumen		SEPP1; SELENOP	Selenium Micronutrient Network; Integrin-mediated Cell Adhesion; Selenium Metabolism and Selenoproteins; Focal Adhesion; ESC Pluripotency Pathways		Platelet degranulation	-0.776725437	0.000825856	0.002277584	FDR <= 0.01	22.47555269	22.52310236	22.39131221	22.41145567	22.27527155	21.80827905	22.13532703	21.41931238	21.66673814	21.1634107
P04432	251	P04432	IGKV1D-39	Immunoglobulin kappa variable 1D-39 OS=Homo sapiens OX=9606 GN=IGKV1D-39 PE=3 SV=2	2	1	31	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV1-39; IGKV1D-39			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.203591277	0.452991134	0.527631719	FDR > 0.05	15.09417114	15.60902419	15.02020249	15.22029089	15.16743358	15.64763598	14.44524167	15.89508904	15.28593477	15.85517723
J3KN67	18	P06753-2;J3KN67;P06753-5;P06753-7;A0A2R2Y2Q3;P06753-6;P06753;P06753-4;P06753-3;A0A087WWU8;A0A494C0P6	TPM3	Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=1	6	2	34	cell organization and biogenesis;cellular component movement	cytoskeleton;cytosol	protein binding;structural molecule activity	TPM3	Striated Muscle Contraction			1.241590672	3.18e-05	0.000142694	FDR <= 0.01	14.22020575	14.33655421	14.3833503	14.31736046	14.709972	15.31747566	15.72357532	15.36290548	16.23810167	15.53333795
Q9NPH3	707	Q9NPH3-2;Q9NPH3;Q9NPH3-5;Q9NPH3-3;C9J1D9;H7C3W4;C9J9W1	IL1RAP	Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2	5	5	30	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	protein binding;receptor activity;signal transducer activity	IL1RAP	IL-1 signaling pathway; Structural Pathway of Interleukin 1 (IL-1)	Cytokine-cytokine receptor interaction; Inflammatory mediator regulation of TRP channels	Receptor-type tyrosine-protein phosphatases; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interleukin-36 pathway; Interleukin-33 signaling	-1.041743531	2.22e-06	1.77e-05	FDR <= 0.01	20.69061954	20.63912019	20.65521286	20.62683359	20.64344383	19.87537257	19.32762497	19.50199878	19.70052757	19.64098847
Q12841	417	Q12841;Q12841-2;C9J5G4	FSTL1	Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1	4	4	20	metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	metal ion binding;protein binding;transporter activity	FSTL1			Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BMP	1.071587767	3.89e-05	0.000169715	FDR <= 0.01	17.28151401	17.35446108	17.44577774	17.34103738	17.20829539	18.53806524	18.20605626	18.88483926	17.97216454	18.38789912
Q9UBG3	650	Q9UBG3	CRNN	Cornulin OS=Homo sapiens OX=9606 GN=CRNN PE=1 SV=1	4	4	16	response to stimulus	cytoplasm;membrane	metal ion binding	CRNN				0.812950106	0.406635114	0.4790816	FDR > 0.05	14.29162438	14.75181512	14.46848729	18.41791363	15.387063	17.23086596	17.62831741	17.68216886	14.19168988	14.64861184
A0A0B4J1X5	291	A0A0B4J1X5	IGHV3-74	Immunoglobulin heavy variable 3-74 OS=Homo sapiens OX=9606 GN=IGHV3-74 PE=3 SV=1	3	1	62	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV3-74				1.303574273	9.99e-05	0.000370034	FDR <= 0.01	19.59039223	19.72905766	19.61879566	19.66898838	19.53085232	21.52703848	21.22310094	21.10949566	20.32328375	20.4730388
P01701	456	P01701	IGLV1-51	Immunoglobulin lambda variable 1-51 OS=Homo sapiens OX=9606 GN=IGLV1-51 PE=1 SV=2	2	2	59	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV1-51			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.809549252	0.004508594	0.009968682	FDR <= 0.01	21.36147197	21.38791079	21.23784195	21.39691017	21.17940584	22.75825371	21.90519131	22.60146869	21.49900506	21.84736821
P30043	150	A0A2R8YEP4;P30043;M0R192	BLVRB	Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3	3	3	15	metabolic process;transport	cytoplasm;cytosol;membrane	catalytic activity	BLVRB	NRF2 pathway	Riboflavin metabolism; Porphyrin and chlorophyll metabolism	Heme degradation	-0.839783388	0.000391742	0.001216775	FDR <= 0.01	16.51057762	16.90253844	16.8329634	16.84205228	16.49876629	15.50051607	16.04110964	16.22563711	16.03654915	15.58416912
F5H3A3	454	F5H3A3	C1R	Complement C1r subcomponent (Fragment) OS=Homo sapiens OX=9606 GN=C1R PE=1 SV=8	2	1	11	metabolic process;regulation of biological process;response to stimulus		catalytic activity;metal ion binding		Oxidative Damage; Complement Activation			1.327520836	3.96e-05	0.000171375	FDR <= 0.01	14.814108	15.05199703	15.46724057	14.99102417	15.06592049	16.1451138	16.14834795	16.63654419	16.09494289	17.0029456
P01034	572	P01034	CST3	Cystatin-C OS=Homo sapiens OX=9606 GN=CST3 PE=1 SV=1	3	3	17	cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;endoplasmic reticulum;endosome;extracellular;membrane;organelle lumen;vacuole	enzyme regulator activity;protein binding	CST3		Salivary secretion	Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Amyloid fiber formation	0.002337574	0.982503383	0.986101155	FDR > 0.05	18.16664424	18.20260225	18.30484227	18.0988965	18.13417057	18.39813843	17.99206972	18.13601416	18.12573863	18.26688277
P34931	618	Q53FA3;P34931;A0A0G2JIW1;P0DMV9;P0DMV8-2;V9GZ37	HSPA1L	Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2	4	1	22	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	cytosol;mitochondrion;organelle lumen	nucleotide binding;protein binding	HSPA1L	Parkin-Ubiquitin Proteasomal System pathway	Legionellosis; Protein processing in endoplasmic reticulum; Longevity regulating pathway - multiple species; Influenza A; Spliceosome; Toxoplasmosis; MAPK signaling pathway; Antigen processing and presentation; Epstein-Barr virus infection; Estrogen signaling pathway; Endocytosis; Measles	Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of HSF1-mediated heat shock response	0.253778905	0.613183325	0.667447336	FDR > 0.05	15.22664091	14.91739219	15.33490315	15.78167595	15.55301771	14.95478055	15.53760118	15.4765786	17.6141857	14.49937841
Q8WVV4-1	212	Q8WVV4-1;Q8WVV4	POF1B	Isoform 1 of Protein POF1B OS=Homo sapiens OX=9606 GN=POF1B	4	4	20	cell organization and biogenesis		protein binding	POF1B				0.451723086	0.07371611	0.109505816	FDR > 0.05	17.88134049	17.48984916	17.39142309	17.78648636	17.19967808	17.71405142	18.56856824	18.31960663	18.02402459	17.38114173
A0A075B7B8	39	A0A075B7B8	IGHV3OR16-12	Immunoglobulin heavy variable 3/OR16-12 (non-functional) (Fragment) OS=Homo sapiens OX=9606 GN=IGHV3OR16-12 PE=1 SV=1	3	2	41	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		catalytic activity;protein binding					-0.218837388	0.154880284	0.203094616	FDR > 0.05	22.26852281	22.11232369	22.04399578	22.11667354	21.96087397	22.06606689	22.04589508	22.01341189	21.38725485	21.89557413
A0A075B6S5	36	A0A075B6S5	IGKV1-27	Immunoglobulin kappa variable 1-27 OS=Homo sapiens OX=9606 GN=IGKV1-27 PE=3 SV=1	2	1	23	response to stimulus	extracellular;membrane		IGKV1-27				-0.1220112	0.527067493	0.589357287	FDR > 0.05	16.57044899	17.01036045	16.55036099	16.73035985	16.78172468	16.90137969	15.92846828	16.63075576	16.73485112	16.8377441
P13796	194	P13796;Q5TBN3	LCP1	Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6	4	3	12	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoplasm;cytoskeleton;cytosol;membrane	metal ion binding;protein binding	LCP1			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling	0.988820833	0.001469409	0.003781116	FDR <= 0.01	17.46756168	17.82216433	17.66719781	17.93104686	18.0680549	19.53704388	18.6483835	18.38635137	19.03603466	18.29231634
P06312	672	P06312	IGKV4-1	Immunoglobulin kappa variable 4-1 OS=Homo sapiens OX=9606 GN=IGKV4-1 PE=1 SV=1	3	3	43	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV4-1			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.322313228	0.092892615	0.133057871	FDR > 0.05	22.3666464	22.47798281	22.41956771	22.39145617	22.23172138	23.37727457	22.53776788	22.67669699	22.43457155	22.47262962
Q9UI42	28	B7Z5J4;Q9UI42-2;Q9UI42	CPA4	Carboxypeptidase A4 OS=Homo sapiens OX=9606 GN=CPA4 PE=1 SV=2	3	3	14	cell organization and biogenesis;metabolic process	extracellular	catalytic activity;metal ion binding;protein binding	CPA4				0.734379588	0.003697638	0.008329844	FDR <= 0.01	16.79945886	16.94344207	16.69875793	16.63747436	17.08394867	17.19156135	18.1817144	17.56708343	17.76037724	17.13424342
Q13835-2	626	Q13835-2;Q13835	PKP1	Isoform 1 of Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1	5	5	31	cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport	cytoskeleton;membrane;nucleus	protein binding;signal transducer activity;structural molecule activity	PKP1				0.477228601	0.091951863	0.132127093	FDR > 0.05	19.02834452	18.31261337	18.22439007	18.85030423	18.24821772	18.71832125	19.70302448	19.18852663	19.07862861	18.36151196
P40197	263	P40197	GP5	Platelet glycoprotein V OS=Homo sapiens OX=9606 GN=GP5 PE=1 SV=1	3	3	20	cell organization and biogenesis;coagulation;metabolic process;response to stimulus	membrane	protein binding	GP5		Platelet activation; Hematopoietic cell lineage; ECM-receptor interaction	Platelet Aggregation (Plug Formation); Intrinsic Pathway of Fibrin Clot Formation; Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	-0.183282941	0.37086676	0.443741357	FDR > 0.05	17.5751978	17.67442422	17.69925092	17.9141491	17.70862044	17.48118637	16.78576129	17.70188541	17.77162759	17.91476712
P52907	669	P52907	CAPZA1	F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3	3	3	12	cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular	protein binding	CAPZA1		Endocytosis	COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Advanced glycosylation endproduct receptor signaling; Factors involved in megakaryocyte development and platelet production; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Interleukin-12 family signaling	0.328204999	0.082798194	0.121529569	FDR > 0.05	16.40329896	16.16210831	16.24854138	16.42168482	16.30342397	16.44985673	16.645242	16.51159615	17.27112647	16.3022611
P23280	492	P23280-2;P23280;P23280-3;F8W148	CA6	Carbonic anhydrase 6 OS=Homo sapiens OX=9606 GN=CA6 PE=1 SV=3	4	4	20	metabolic process;response to stimulus;transport	cytoplasm;cytosol;extracellular	catalytic activity;metal ion binding	CA6		Nitrogen metabolism	Reversible hydration of carbon dioxide	-0.482046176	0.004729614	0.010351291	FDR <= 0.05	18.52181825	18.41418749	18.5097073	18.46402345	18.47081046	18.31470086	18.16133575	17.83796805	18.05374267	17.60256874
Q06830	558	A0A0A0MSI0;Q06830;A0A0A0MRQ5	PRDX1	Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1	4	2	19	cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;mitochondrion;nucleus	antioxidant activity;catalytic activity;protein binding;RNA binding	PRDX1	Androgen receptor signaling pathway; Selenium Micronutrient Network; NRF2 pathway	Peroxisome	TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species	0.791121982	0.000130676	0.000472738	FDR <= 0.01	19.51733558	19.24307622	19.23323048	19.48250447	19.12323309	19.88761791	20.26351905	20.18582091	20.35814282	19.85988906
P62805	476	P62805	H4C1	Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2	4	4	32	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus	chromosome;extracellular;membrane;nucleus	DNA binding;protein binding;RNA binding	HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L	Gastric Cancer Network 1; Histone Modifications; Type II interferon signaling (IFNG)	Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism	SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence	0.654361809	0.411245906	0.483300342	FDR > 0.05	17.82608511	18.07080766	17.66511207	18.5324754	20.27501904	18.51369712	18.81115666	18.31581886	22.02719517	17.97344051
Q5T749	246	Q5T749	KPRP	Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1	3	3	16		cytoplasm	protein binding	KPRP				0.702901552	0.000417246	0.001264069	FDR <= 0.01	19.42558582	19.32891234	19.22792119	19.35984514	19.13496992	20.3095314	20.19825188	19.89187205	19.97581156	19.61627528
P47929	554	P47929	LGALS7	Galectin-7 OS=Homo sapiens OX=9606 GN=LGALS7 PE=1 SV=2	2	2	21	cell death	cytoplasm;extracellular;nucleus		LGALS7; LGALS7B				1.071903967	0.064669762	0.098445306	FDR > 0.05	18.79997467	18.4494176	18.62807595	18.89898622	18.43239379	19.40446826	19.48306115	19.34127579	21.9209083	18.41865458
P27482	128	P27482	CALML3	Calmodulin-like protein 3 OS=Homo sapiens OX=9606 GN=CALML3 PE=1 SV=2	3	3	12			metal ion binding;protein binding	CALML3	Alzheimers Disease	Neurotrophin signaling pathway; Gastric acid secretion; Vascular smooth muscle contraction; Pertussis; Phosphatidylinositol signaling system; Estrogen signaling pathway; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Dopaminergic synapse; Tuberculosis; Long-term potentiation; GnRH signaling pathway; Insulin signaling pathway; Melanogenesis; Olfactory transduction; Alcoholism; Phototransduction; Glucagon signaling pathway; Rap1 signaling pathway; Salivary secretion; Adrenergic signaling in cardiomyocytes; Calcium signaling pathway; Renin secretion; Oocyte meiosis; Glioma; cAMP signaling pathway; Amphetamine addiction; Alzheimer's disease; Circadian entrainment; Ras signaling pathway		0.766111204	0.030188587	0.05128724	FDR > 0.05	19.36818774	19.43881622	19.42607922	19.79036245	19.63348957	19.89269856	20.39711026	19.85765094	21.55167481	19.78835664
Q14574	553	Q14574-2;Q14574	DSC3	Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3	4	3	19	cell death;regulation of biological process	cytoskeleton;membrane	metal ion binding;protein binding	DSC3			Formation of the cornified envelope	0.108803801	0.535411287	0.595439315	FDR > 0.05	18.11812185	18.07404319	17.93354749	18.19858435	17.94658775	17.85476678	18.60529096	18.33240775	18.31228382	17.71015432
E9PK25	302	E9PP50;P23528;E9PK25;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3	CFL1	Cofilin, non-muscle isoform OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=1	4	4	20	cell organization and biogenesis	cytoskeleton	protein binding					0.219627813	0.545371684	0.605421635	FDR > 0.05	19.29152935	19.2787064	19.28573976	19.40837257	19.64228002	19.56773406	19.06154031	19.09923813	21.11141692	19.16483775
Q7Z7M0	211	Q7Z7M0-2;Q7Z7M0	MEGF8	Multiple epidermal growth factor-like domains protein 8 OS=Homo sapiens OX=9606 GN=MEGF8 PE=1 SV=2	4	4	13	cellular component movement;regulation of biological process;response to stimulus	membrane;nucleus	metal ion binding;protein binding	MEGF8				-0.453746125	0.003133289	0.00754031	FDR <= 0.01	17.25074901	17.25785902	17.2362883	17.41528477	17.10265682	16.91657649	16.46034801	16.7662875	16.92252709	16.92836821
Q8NBS9	446	Q8NBS9;Q8NBS9-2	TXNDC5	Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2	3	3	12	cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;extracellular;organelle lumen	catalytic activity;protein binding	TXNDC5		Protein processing in endoplasmic reticulum	Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis	0.936745987	7.3e-06	4.54e-05	FDR <= 0.01	16.10688842	16.4680816	16.35532664	16.23144898	16.31302896	17.4879428	17.15165603	17.12324605	17.31656949	17.07909017
Q8IZF2	278	Q8IZF2-2;Q8IZF2;Q8IZF2-3	ADGRF5	Adhesion G protein-coupled receptor F5 OS=Homo sapiens OX=9606 GN=ADGRF5 PE=1 SV=3	4	4	12	cell differentiation;metabolic process;regulation of biological process;response to stimulus	cell surface;membrane	receptor activity;signal transducer activity	GPR116; ADGRF5	GPCRs, Other		Surfactant metabolism	-0.034423165	0.731548963	0.766443973	FDR > 0.05	18.21453925	18.3949407	18.30065402	18.3417731	18.35239883	18.36344559	18.419458	18.17721625	18.12041003	18.35166022
A0A5F9ZHM4	279	P07195;A0A5F9ZHM4;A8MW50;A0A3B3IS95;C9J7H8	LDHB	L-lactate dehydrogenase OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=1	4	3	15								-0.434867903	0.019180398	0.034693955	FDR <= 0.05	19.00214931	19.06373742	19.01195128	18.97465176	18.9190971	18.41833753	18.08577481	18.95039678	18.84259287	18.50014536
Q9H6X2	615	Q9H6X2;Q9H6X2-5;Q9H6X2-2;Q9H6X2-3;Q9H6X2-4;Q9H6X2-6	ANTXR1	Anthrax toxin receptor 1 OS=Homo sapiens OX=9606 GN=ANTXR1 PE=1 SV=2	3	3	12	cell organization and biogenesis;regulation of biological process;response to stimulus	cell surface;membrane	metal ion binding;protein binding;receptor activity;signal transducer activity	ANTXR1		NOD-like receptor signaling pathway	Uptake and function of anthrax toxins	-0.891947788	7.46e-05	0.00029569	FDR <= 0.01	16.04650199	16.04161294	15.85139722	15.86820003	15.86655898	15.44479494	14.98985244	15.18234297	14.9258241	14.67171777
P22735	82	P22735	TGM1	Protein-glutamine gamma-glutamyltransferase K OS=Homo sapiens OX=9606 GN=TGM1 PE=1 SV=4	4	4	15	cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process	cytoskeleton;cytosol;membrane	catalytic activity;metal ion binding;protein binding	TGM1			Formation of the cornified envelope	1.129311885	9.58e-06	5.56e-05	FDR <= 0.01	17.77197491	17.65390453	17.45729236	17.93854119	17.44221008	18.52590844	19.1117751	18.70421893	18.88699993	18.68158009
O00754	639	O00754;O00754-2	MAN2B1	Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3	3	3	12	metabolic process;transport	extracellular;organelle lumen;vacuole	catalytic activity;metal ion binding	MAN2B1		Lysosome; Other glycan degradation	Neutrophil degranulation; Lysosomal oligosaccharide catabolism	0.859768594	0.006286806	0.013195855	FDR <= 0.05	12.73781806	12.6131163	13.27382628	13.03479438	13.1903937	14.08443163	14.67604025	13.48266153	13.34724525	13.55841305
P58335	556	P58335;J3KPY9;P58335-4;P58335-2;P58335-3;A0A0C4DG84	ANTXR2	Anthrax toxin receptor 2 OS=Homo sapiens OX=9606 GN=ANTXR2 PE=1 SV=5	3	3	12	transport	cell surface;endoplasmic reticulum;extracellular;membrane	metal ion binding;protein binding;receptor activity	ANTXR2		NOD-like receptor signaling pathway	Uptake and function of anthrax toxins	-0.40874196	0.011354929	0.022382312	FDR <= 0.05	18.58347161	18.66228653	18.62527666	18.73866196	18.60114891	18.23912849	17.87605454	18.48971386	18.06427444	18.49796454
P35579	525	P35579	MYH9	Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4	3	3	16	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus	catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity	MYH9	Primary Focal Segmental Glomerulosclerosis FSGS; VEGFA-VEGFR2 Signaling Pathway	Regulation of actin cytoskeleton; Tight junction; Salmonella infection	RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate CIT; RHO GTPases activate PKNs	0.716314194	0.027036394	0.046315828	FDR <= 0.05	17.58947215	17.4586281	17.64429267	17.8103259	18.03282852	18.1507527	19.29174604	18.00675626	18.92142325	17.74644006
Q9HCY8	441	Q9HCY8	S100A14	Protein S100-A14 OS=Homo sapiens OX=9606 GN=S100A14 PE=1 SV=1	3	3	16	cell death;defense response;regulation of biological process;response to stimulus	cytoplasm;cytosol	metal ion binding;protein binding	S100A14				0.579138409	0.100472088	0.14270285	FDR > 0.05	17.86031202	17.57782854	17.35301186	18.41195146	17.43622455	17.8438509	18.87259931	18.55336759	18.90474042	17.36046226
Q6UWP8	531	Q6UWP8	SBSN	Suprabasin OS=Homo sapiens OX=9606 GN=SBSN PE=1 SV=2	3	3	11		extracellular		SBSN				0.717170916	0.002366472	0.005821521	FDR <= 0.01	17.31826637	17.65237447	17.55309733	17.20065491	17.38784423	17.9413334	18.75415285	18.18882779	18.04990038	17.76387747
P37837	612	P37837	TALDO1	Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2	4	4	24	metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;nucleus	catalytic activity;protein binding	TALDO1	Pentose Phosphate Pathway; Cori Cycle	Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Pentose phosphate pathway	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P; Interleukin-12 family signaling; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; Pentose phosphate pathway (hexose monophosphate shunt)	-0.132766776	0.532182672	0.592920911	FDR > 0.05	18.26830781	18.37770552	18.23500495	18.62537464	18.41256156	18.02743036	18.14661551	18.84910561	18.56571462	17.66625449
Q04721	726	Q04721;D2WEZ3	NOTCH2	Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3	3	3	16	cell death;cell differentiation;development;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;extracellular;membrane;nucleus	metal ion binding;protein binding;receptor activity;signal transducer activity	NOTCH2	Neural Crest Differentiation; Notch Signaling Pathway; Canonical  and Non-canonical Notch signaling; Role of Osx and miRNAs in tooth development; Notch Signaling Pathway	Breast cancer; Endocrine resistance; Dorso-ventral axis formation; Thyroid hormone signaling pathway; MicroRNAs in cancer; Th1 and Th2 cell differentiation; Notch signaling pathway	NOTCH2 Activation and Transmission of Signal to the Nucleus; Defective LFNG causes SCDO3; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in the Endoplasmic Reticulum; NOTCH2 intracellular domain regulates transcription	0.182898125	0.098180895	0.139771413	FDR > 0.05	17.50154897	17.59495301	17.56071808	17.77569171	17.55390153	17.71030632	17.99502772	17.74834139	17.72619081	17.72143768
Q9Y5C1	72	Q9Y5C1	ANGPTL3	Angiopoietin-related protein 3 OS=Homo sapiens OX=9606 GN=ANGPTL3 PE=1 SV=1	3	3	22	metabolic process;regulation of biological process;response to stimulus	cell surface;endosome;extracellular;Golgi	enzyme regulator activity;protein binding	ANGPTL3			Assembly of active LPL and LIPC lipase complexes	0.84534237	0.000107963	0.000397588	FDR <= 0.01	21.17571658	21.29352692	21.20858962	21.3910333	21.05360972	21.69995263	21.88278418	22.18819269	22.19357042	22.38468808
A0A075B6H9	113	A0A075B6H9	IGLV4-69	Immunoglobulin lambda variable 4-69 OS=Homo sapiens OX=9606 GN=IGLV4-69 PE=1 SV=1	3	3	61	response to stimulus	extracellular;membrane		IGLV4-69				0.707746393	0.014484593	0.027325229	FDR <= 0.05	21.08279488	21.23518953	21.22386228	21.29166458	21.13553321	22.70203996	22.23600016	21.86694826	21.40822072	21.29456734
P05362	550	P05362;E7ESS4	ICAM1	Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2	3	3	12	cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;regulation of biological process;response to stimulus	cell surface;membrane	protein binding;receptor activity;signal transducer activity	ICAM1	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Interleukin-11 Signaling Pathway; Spinal Cord Injury; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 Signaling Pathway; Type II interferon signaling (IFNG)	African trypanosomiasis; Malaria; Natural killer cell mediated cytotoxicity; Staphylococcus aureus infection; AGE-RAGE signaling pathway in diabetic complications; Epstein-Barr virus infection; Leukocyte transendothelial migration; HTLV-I infection; Rheumatoid arthritis; NF-kappa B signaling pathway; Influenza A; Cell adhesion molecules (CAMs); Viral myocarditis; TNF signaling pathway	Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and 13 signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling	0.403746009	0.36957235	0.443054572	FDR > 0.05	17.48950369	17.42165903	17.38199518	17.39926683	17.44380965	17.15680365	17.27750463	16.73997118	18.75402099	19.22666398
Q6UVK1	584	Q6UVK1	CSPG4	Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2	2	2	9	cell differentiation;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus	cell surface;extracellular;membrane;organelle lumen	protein binding;signal transducer activity	CSPG4	Spinal Cord Injury		A tetrasaccharide linker sequence is required for GAG synthesis; Dermatan sulfate biosynthesis; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD	0.085081961	0.660825018	0.706795454	FDR > 0.05	16.23079635	16.6839516	16.4473912	16.51450445	16.43651614	17.21053444	16.29858	16.68116323	16.2837931	16.26449877
E9PKU7	227	F5H6X6;Q14697;Q14697-2;E9PKU7	GANAB	Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=1	4	4	16	metabolic process	Golgi;membrane;organelle lumen	catalytic activity;RNA binding	GANAB				0.473452469	0.008657442	0.017514233	FDR <= 0.05	15.76871664	15.8882963	15.87693313	15.25801042	15.81799339	16.14253135	16.45040958	16.13110076	15.96908054	16.28408999
P00451	363	P00451	F8	Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1	3	3	7	cell organization and biogenesis;coagulation;defense response;metabolic process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	F8	Blood Clotting Cascade; Complement and Coagulation Cascades	Complement and coagulation cascades	Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; Intrinsic Pathway of Fibrin Clot Formation	0.211012728	0.117184391	0.160152001	FDR > 0.05	17.50317223	17.7728716	17.77735521	17.58650194	17.90634339	17.9539594	18.21760631	17.79869157	17.87675229	17.75429845
P01036	168	P01036;P01037;P09228	CST4	Cystatin-S OS=Homo sapiens OX=9606 GN=CST4 PE=1 SV=3	3	3	20	regulation of biological process;response to stimulus	extracellular	enzyme regulator activity;protein binding	CST4		Salivary secretion		0.63238757	0.047917616	0.075951891	FDR > 0.05	17.23736026	17.16071288	17.09049563	17.83317994	17.21891089	18.35152632	18.65398172	18.13096366	17.38147226	17.18465349
C9JCK5	138	P25787;A0A7I2YQP7;C9JCK5	PSMA2	Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=1	2	2	5	metabolic process	cytoplasm;proteasome	catalytic activity					-0.001336938	0.99102231	0.99102231	FDR > 0.05	15.59728368	15.88232036	15.90957059	15.92127565	15.76751808	16.00071155	15.77349972	15.87806892	15.87243533	15.54656815
P34096	384	P34096	RNASE4	Ribonuclease 4 OS=Homo sapiens OX=9606 GN=RNASE4 PE=1 SV=3	2	2	12	metabolic process	extracellular	catalytic activity	RNASE4				-1.40159242	3.84e-05	0.000168701	FDR <= 0.01	17.45366281	17.4180545	17.41650705	17.5691726	17.20873549	15.90317783	16.55947413	15.53100367	16.4622676	15.60224712
A0A075B6I1	253	A0A075B6I1	IGLV4-60	Immunoglobulin lambda variable 4-60 OS=Homo sapiens OX=9606 GN=IGLV4-60 PE=3 SV=1	3	3	96	response to stimulus	extracellular;membrane		IGLV4-60				0.332786591	0.616930543	0.669157467	FDR > 0.05	23.92711536	23.70803168	23.66604652	23.86667748	23.64170955	26.12607175	24.19148452	21.52666943	24.37451294	24.2547749
O43157	290	O43157;O43157-2	PLXNB1	Plexin-B1 OS=Homo sapiens OX=9606 GN=PLXNB1 PE=1 SV=3	2	2	8	cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	extracellular;membrane	enzyme regulator activity;protein binding;receptor activity;signal transducer activity	PLXNB1		Axon guidance	Sema4D mediated inhibition of cell attachment and migration; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse	0.451305111	0.005385181	0.011620654	FDR <= 0.05	16.9285838	17.11162535	16.90653528	16.92964983	16.65660454	17.64324372	17.43013552	17.28190072	17.07542044	17.35882395
P11279	172	P11279;P11279-2	LAMP1	Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3	3	3	9	cell death;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endosome;membrane;vacuole	protein binding;receptor activity	LAMP1	Senescence and Autophagy in Cancer	Lysosome; Tuberculosis; Phagosome	Neutrophil degranulation	-0.038250825	0.827840642	0.855667218	FDR > 0.05	18.77415922	18.84752332	18.75172799	18.79690121	18.69083899	18.39974963	19.02472275	18.74751261	19.19822017	18.29969145
J3QTR3	100	F5GXK7;B4DV12;F5H388;Q96C32;P0CG48;F5GYU3;P62987;M0R1M6;F5H747;M0R2S1;P0CG47;J3QKN0;F5H6Q2;A0A2R8Y422;J3QS39;F5H2Z3;J3QTR3;Q5PY61;P62979;F5H265;M0R1V7	RPS27A	Ubiquitin-40S ribosomal protein S27a (Fragment) OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=1	3	3	24			protein binding					0.509873259	0.006049353	0.012784715	FDR <= 0.05	18.65804586	18.66364969	18.66017356	18.82122814	18.58706774	18.97158653	19.61810815	19.17305718	19.35461727	18.82216216
P31949	593	P31949	S100A11	Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2	2	2	9	regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;nucleus;organelle lumen	metal ion binding;protein binding	S100A11			Neutrophil degranulation	0.676401778	0.173416131	0.224056556	FDR > 0.05	14.48203728	14.76580968	14.76242199	16.01009899	15.98449065	14.97896867	15.74797503	15.68289108	17.42554076	15.55149194
P23141	282	P23141;P23141-2;P23141-3	CES1	Liver carboxylesterase 1 OS=Homo sapiens OX=9606 GN=CES1 PE=1 SV=2	2	2	8	cell differentiation;metabolic process;response to stimulus	cytosol;endoplasmic reticulum;organelle lumen	catalytic activity	CES1	Phase I biotransformations, non P450; Fluoropyrimidine Activity; Irinotecan Pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling	Drug metabolism - other enzymes; Metabolic pathways	Phase I - Functionalization of compounds	0.157274947	0.367230955	0.441107495	FDR > 0.05	16.16880042	16.39909384	16.62711033	16.24103353	16.51020712	16.3578404	16.51606831	16.49788775	16.25860129	17.10222223
A0A0B4J1V2	126	A0A0B4J1V2	IGHV2-26	Immunoglobulin heavy variable 2-26 OS=Homo sapiens OX=9606 GN=IGHV2-26 PE=3 SV=1	3	2	13	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV2-26				0.292268682	0.105143755	0.145967064	FDR > 0.05	20.62669475	20.68228364	20.5356664	20.64796709	20.4875184	21.41040606	20.76265868	21.09455062	20.49830794	20.6755504
Q9NZ08	445	Q9NZ08;Q9NZ08-2	ERAP1	Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3	3	3	9	cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding	ERAP1			Antigen Presentation: Folding, assembly and peptide loading of class I MHC	-0.367587572	0.010977345	0.021707612	FDR <= 0.05	17.18121464	17.23159812	17.32365631	17.36669512	17.12466533	16.98419112	16.50954985	17.00139931	16.94919205	16.94555932
A0A075B7F0	276	A0A075B7F0	IGHV3OR16-10	Immunoglobulin heavy variable 3/OR16-10 (non-functional) (Fragment) OS=Homo sapiens OX=9606 GN=IGHV3OR16-10 PE=1 SV=1	2	1	11	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding					-0.014453021	0.948561651	0.959759166	FDR > 0.05	16.47777999	16.5359614	16.66049344	16.4315485	16.54405549	17.28269025	16.26296256	16.81261165	16.14859544	16.07071381
A0A0S2Z4G6	305	P09493;P09493-7;P09493-10;P09493-8;P09493-6;P09493-3;Q6ZN40;P09493-4;P09493-9;A0A0S2Z4G6;H7BYY1;H0YK48;F5H7S3;A0A494BZZ2;P09493-5;B7Z596;H0YKX5;P09493-2;H0YKJ4;H0YL42;A0A494C0V8	TPM1	Tropomyosin 1 (Alpha), isoform CRA_o (Fragment) OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=1	4	1	19	cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	cytoskeleton;cytosol	protein binding;structural molecule activity	TPM1	Striated Muscle Contraction			0.619836154	0.003138731	0.00754031	FDR <= 0.01	13.9823604	13.3322977	13.68916496	13.67084329	13.81489366	14.14885007	14.31028116	14.59067177	13.95172137	14.58721641
P05164	9	P05164-2;P05164;P05164-3	MPO	Myeloperoxidase OS=Homo sapiens OX=9606 GN=MPO PE=1 SV=1	3	3	16	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;mitochondrion;nucleus;organelle lumen;vacuole	antioxidant activity;catalytic activity;metal ion binding	MPO	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Benzene metabolism	Phagosome; Transcriptional misregulation in cancer	Neutrophil degranulation	0.714341104	0.028056412	0.047796934	FDR <= 0.05	18.01799329	18.11815511	18.025171	18.06167636	19.4733572	19.08907671	18.9623011	18.70173022	19.47763514	19.03731532
Q14517	73	A0A087WVP1;Q14517	FAT1	Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2	4	4	13	cell communication;cell organization and biogenesis;cellular component movement	cell surface;cytoplasm;membrane;nucleus	metal ion binding;protein binding	FAT1	Primary Focal Segmental Glomerulosclerosis FSGS			0.319700004	0.024453339	0.042362827	FDR <= 0.05	17.52233852	17.57712876	17.48718936	17.51646867	17.56970021	17.92594457	17.4348937	17.95631374	17.96752012	17.98665342
P02794	590	G3V192;P02794;G3V1D1;E9PRK8;E9PPQ4	FTH1	Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2	4	4	20	cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytosol;extracellular;nucleus;vacuole	catalytic activity;metal ion binding;protein binding	FTH1	Iron metabolism in placenta; NRF2 pathway	Mineral absorption	Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors	-0.18717649	0.366738222	0.441107495	FDR > 0.05	19.00318447	19.01322025	18.98467807	19.0316124	18.91016683	18.95612862	19.35165442	18.18108133	19.03685972	18.48125547
C9JUP7	88	P55072;A0A7I2V540;C9JUP7	VCP	Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=2	3	3	12								1.535232337	0.000484888	0.00142003	FDR <= 0.01	13.54553366	13.9385608	13.96923328	14.54444475	13.64973391	15.50931112	14.79658019	14.97726142	16.50816526	15.53235012
A0A0B4J1Y8	680	A0A0B4J1Y8	IGLV9-49	Immunoglobulin lambda variable 9-49 OS=Homo sapiens OX=9606 GN=IGLV9-49 PE=1 SV=1	2	2	20	response to stimulus	extracellular;membrane	protein binding	IGLV9-49				0.667149464	0.059133502	0.092054854	FDR > 0.05	21.07774073	21.29429731	20.99014882	20.99275379	20.88535224	21.69940117	20.71768014	22.87985654	21.54219578	21.73690658
A0A075B6I9	42	A0A075B6I9	IGLV7-46	Immunoglobulin lambda variable 7-46 OS=Homo sapiens OX=9606 GN=IGLV7-46 PE=3 SV=4	2	1	75	response to stimulus	extracellular;membrane		IGLV7-46				0.718903406	0.051033392	0.080682613	FDR > 0.05	24.23628042	24.09102825	24.10986269	24.13013342	23.87037963	26.1496222	24.93840335	24.45576865	24.34387351	24.14453372
Q9Y6Z7	35	Q9Y6Z7	COLEC10	Collectin-10 OS=Homo sapiens OX=9606 GN=COLEC10 PE=1 SV=2	3	3	18	defense response;metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular;Golgi	catalytic activity	COLEC10			Lectin pathway of complement activation	-0.006415254	0.95565928	0.965074643	FDR > 0.05	18.46434144	18.47792242	18.31787441	18.30649805	18.30800373	18.23139571	18.4320736	18.21298981	18.30242636	18.66367831
Q8NI99	249	K7EKF6;Q8NI99	ANGPTL6	Angiopoietin-related protein 6 OS=Homo sapiens OX=9606 GN=ANGPTL6 PE=1 SV=1	3	3	12	cell differentiation;development	extracellular		ANGPTL6				0.297197587	0.060262052	0.093118498	FDR > 0.05	16.25402422	16.22633959	16.40506241	16.71294527	16.31394754	16.55327815	16.57453418	16.87224755	16.43204668	16.9662004
Q03167	226	Q03167;Q03167-2	TGFBR3	Transforming growth factor beta receptor type 3 OS=Homo sapiens OX=9606 GN=TGFBR3 PE=1 SV=3	2	2	8	cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;extracellular;membrane	catalytic activity;protein binding;receptor activity;signal transducer activity	TGFBR3	Extracellular vesicle-mediated signaling in recipient cells; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-beta Receptor Signaling			-0.48430509	0.031588373	0.053370466	FDR > 0.05	14.60310894	14.94189108	15.1260504	14.81994086	15.06454443	14.75708326	13.71216368	14.54698653	14.5047905	14.61298628
A0A075B6K0	675	A0A075B6K0	IGLV3-16	Immunoglobulin lambda variable 3-16 OS=Homo sapiens OX=9606 GN=IGLV3-16 PE=3 SV=2	2	1	58	response to stimulus	extracellular;membrane		IGLV3-16				-0.77162588	3.06e-05	0.000139416	FDR <= 0.01	21.02625819	20.99332717	20.97867862	20.98524939	20.90415702	20.48023318	19.92549768	20.22981495	20.21431127	20.17968391
Q13790	319	Q13790	APOF	Apolipoprotein F OS=Homo sapiens OX=9606 GN=APOF PE=1 SV=2	3	3	24	metabolic process;transport	extracellular	protein binding;transporter activity	APOF			LDL remodeling	0.126149681	0.630752017	0.67816869	FDR > 0.05	19.76131814	19.9965868	19.83051885	19.7661465	19.89684898	20.02255595	19.01947372	20.57124133	19.82156607	20.4473306
Q96P63	438	Q96P63-2;Q96P63	SERPINB12	Serpin B12 OS=Homo sapiens OX=9606 GN=SERPINB12 PE=1 SV=1	3	3	12	cell differentiation;regulation of biological process;transport	cytoplasm;membrane	enzyme regulator activity;protein binding	SERPINB12			Neutrophil degranulation	0.317954052	0.462916062	0.535137929	FDR > 0.05	19.50688123	19.2717184	18.7110991	19.23596552	18.68127	18.7780701	20.40317788	19.85184104	19.97473802	17.98887747
H0YN18	258	H0YN18;P25789;H0YKT8;H0YMZ1;H0YL69;H0YLC2;H0YMA1;P25789-2	PSMA4	Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1	3	3	15	metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;protein binding	PSMA4	Proteasome Degradation; Exercise-induced Circadian Regulation			0.398827584	0.004644018	0.010200254	FDR <= 0.05	16.11659071	16.25901576	16.13161963	16.19422752	16.19474804	16.73447933	16.45158173	16.56328374	16.8049269	16.33606787
P00918	687	P00918	CA2	Carbonic anhydrase 2 OS=Homo sapiens OX=9606 GN=CA2 PE=1 SV=2	3	3	12	cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;membrane	catalytic activity;metal ion binding;protein binding	CA2		Pancreatic secretion; Gastric acid secretion; Bile secretion; Collecting duct acid secretion; Nitrogen metabolism; Proximal tubule bicarbonate reclamation	Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide	-0.181598667	0.115958264	0.158829249	FDR > 0.05	17.96935824	18.1036337	18.07593042	17.88598284	18.12954785	17.68709046	17.87691126	18.07422093	17.87441643	17.74382062
P09382	107	P09382	LGALS1	Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2	2	2	8	cell death;cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;cytosol;extracellular;nucleus;organelle lumen	protein binding;RNA binding;signal transducer activity	LGALS1			Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-0.054995697	0.879136599	0.896631855	FDR > 0.05	17.85655728	17.7371148	17.85168878	17.81942993	17.79945804	17.74888583	17.27772702	17.41574751	19.27734316	17.06956683
Q8WWZ8	137	Q8WWZ8	OIT3	Oncoprotein-induced transcript 3 protein OS=Homo sapiens OX=9606 GN=OIT3 PE=1 SV=2	3	3	12		nucleus	metal ion binding;protein binding	OIT3				0.324320188	0.026522031	0.04556159	FDR <= 0.05	16.44009719	16.6052439	16.49828314	16.7332271	16.59561365	16.99033325	16.73663019	17.15339127	16.59840932	17.01530189
A0A075B7B6	565	A0A075B7B6	IGHV4OR15-8	Immunoglobulin heavy variable 4/OR15-8 (non-functional) (Fragment) OS=Homo sapiens OX=9606 GN=IGHV4OR15-8 PE=4 SV=1	3	2	39								0.496016371	0.040714751	0.066389021	FDR > 0.05	22.30082465	22.48571131	22.48631518	22.52244088	22.52485092	23.50673839	22.86489166	23.35947027	22.24175153	22.82737294
P27797	715	P27797	CALR	Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1	3	3	24	cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus;organelle lumen	DNA binding;metal ion binding;protein binding;RNA binding	CALR	Androgen receptor signaling pathway; Photodynamic therapy-induced unfolded protein response; Calcium Regulation in the Cardiac Cell	HTLV-I infection; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Phagosome; Chagas disease (American trypanosomiasis)	Scavenging by Class F Receptors; Assembly of Viral Components at the Budding Site; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Calnexin/calreticulin cycle; Scavenging by Class A Receptors	-0.925791551	0.007674273	0.015784876	FDR <= 0.05	18.34335581	18.24371235	18.19637455	18.25666001	18.44269633	17.29736881	17.22111807	16.89792482	18.55972155	16.87770806
Q8TDL5	557	Q8TDL5	BPIFB1	BPI fold-containing family B member 1 OS=Homo sapiens OX=9606 GN=BPIFB1 PE=1 SV=1	2	2	8	defense response;regulation of biological process;response to stimulus	extracellular		BPIFB1			Antimicrobial peptides	0.087711476	0.675226927	0.718450796	FDR > 0.05	17.99483675	17.8466134	17.93186242	17.98302097	17.83331824	18.17508218	17.3368393	17.84311362	18.02973376	18.6434403
Q99969	333	Q99969	RARRES2	Retinoic acid receptor responder protein 2 OS=Homo sapiens OX=9606 GN=RARRES2 PE=1 SV=1	2	2	15	cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	RARRES2			Platelet degranulation	-0.686043607	0.033948719	0.057044979	FDR > 0.05	17.79404898	17.76045383	17.66552949	17.67295597	17.77684553	16.8056667	16.59849998	18.27637984	16.86006543	16.69900382
P68371	652	P68371;Q13509;P04350	TUBB4B	Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1	3	3	5	cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity	TUBB4B	Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway	Gap junction; Phagosome; Pathogenic Escherichia coli infection	COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation	1.128797395	2.68e-05	0.000123218	FDR <= 0.01	16.94633408	17.07306786	17.08825061	17.27097482	17.34102519	18.0551386	18.24425921	17.92730259	18.76218739	18.37475174
Q9BXN1	421	Q9BXN1	ASPN	Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2	2	2	7	regulation of biological process;response to stimulus	cytoplasm;extracellular	enzyme regulator activity;metal ion binding;protein binding	ASPN			ECM proteoglycans	-0.262236126	0.054005204	0.084944247	FDR > 0.05	16.40658265	16.57190998	16.6327608	16.69246945	16.7258215	16.42984549	16.04753689	16.44338028	16.24577373	16.55182737
O43505	727	O43505	B4GAT1	Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1	3	3	14	cellular component movement;metabolic process	Golgi;membrane	catalytic activity;metal ion binding;protein binding	B3GNT1; B4GAT1		Glycosaminoglycan biosynthesis - keratan sulfate; Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series	Keratan sulfate biosynthesis; O-linked glycosylation	-0.574295373	7.82e-05	0.000304376	FDR <= 0.01	18.74807071	18.80935029	18.73752591	18.79832568	18.65210908	18.0468016	18.28948138	18.27705544	18.14625846	18.11430793
P02792	585	P02792	FTL	Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2	2	2	8	cellular homeostasis;transport	cytosol;extracellular;membrane;organelle lumen;vacuole	metal ion binding;protein binding	FTL	NRF2 pathway	Mineral absorption	Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors	0.478643505	0.004395706	0.009794779	FDR <= 0.01	16.66527293	16.59961039	16.34006471	16.68060532	16.52549748	17.36751477	17.00214991	16.92424525	16.74557371	17.1647847
O95274	197	O95274	LYPD3	Ly6/PLAUR domain-containing protein 3 OS=Homo sapiens OX=9606 GN=LYPD3 PE=1 SV=2	2	2	8	metabolic process	extracellular;membrane	protein binding	LYPD3			Post-translational modification: synthesis of GPI-anchored proteins	0.716983808	0.004429021	0.009833387	FDR <= 0.01	16.35010227	16.3228497	16.12529501	16.74882375	16.47216206	16.76512982	17.69959467	17.09343027	17.33464224	16.71135483
P49746	237	Q2HIZ1;F5H4Z8;P49746-2;P49746	THBS3	Thrombospondin-3 OS=Homo sapiens OX=9606 GN=THBS3 PE=1 SV=1	3	2	16		extracellular	metal ion binding	THBS3	Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway	PI3K-Akt signaling pathway; Malaria; Phagosome; ECM-receptor interaction; Focal adhesion	Signaling by PDGF	0.751649503	0.004845657	0.010567656	FDR <= 0.05	14.66777299	14.65971453	14.90168384	14.93603867	14.70164321	15.34365088	15.26920026	16.31837185	15.06251595	15.63136181
P26022	203	P26022	PTX3	Pentraxin-related protein PTX3 OS=Homo sapiens OX=9606 GN=PTX3 PE=1 SV=3	3	3	15	defense response;regulation of biological process;response to stimulus;transport	extracellular;organelle lumen	protein binding	PTX3	Lung fibrosis		Neutrophil degranulation	0.954746573	0.000203858	0.000700404	FDR <= 0.01	15.27277916	15.47892958	15.41922677	15.43321865	15.43687712	16.82368645	16.38228616	16.02058932	15.93330933	16.65489287
P12318	448	P12318-2;P12318	FCGR2A	Low affinity immunoglobulin gamma Fc region receptor II-a OS=Homo sapiens OX=9606 GN=FCGR2A PE=1 SV=4	2	2	4	regulation of biological process;response to stimulus;transport	membrane	protein binding	FCGR2A	Spinal Cord Injury	Fc gamma R-mediated phagocytosis; Tuberculosis; Systemic lupus erythematosus; Osteoclast differentiation; Platelet activation; Staphylococcus aureus infection; Phagosome; Leishmaniasis	FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Role of phospholipids in phagocytosis	0.032391009	0.865686851	0.887329022	FDR > 0.05	16.78649683	16.73796831	16.69043757	16.83784066	16.83128647	17.32266978	16.42265676	17.06954317	16.30895524	16.92215993
P17931	515	P17931	LGALS3	Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5	2	2	14	cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;membrane;nucleus;spliceosomal complex	protein binding;RNA binding	LGALS3	AGE/RAGE pathway; Spinal Cord Injury		RUNX2 regulates genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	-0.053114763	0.837004316	0.862400914	FDR > 0.05	15.7487914	15.45338098	15.40631867	15.58202046	15.77315814	15.19665782	14.76692016	15.71159475	16.33979815	15.68312495
Q13103	38	Q13103	SPP2	Secreted phosphoprotein 24 OS=Homo sapiens OX=9606 GN=SPP2 PE=1 SV=1	2	2	23	metabolic process;regulation of biological process;transport	extracellular;organelle lumen	enzyme regulator activity	SPP2			Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	-1.008271362	1.52e-05	8.06e-05	FDR <= 0.01	19.38289718	19.37861904	19.3736809	19.40820139	19.2834465	18.37864554	18.02785156	18.44745884	18.1779976	18.75353466
A1L4H1	230	A1L4H1;A1L4H1-2	SSC5D	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D OS=Homo sapiens OX=9606 GN=SSC5D PE=1 SV=3	3	3	12	defense response;development;regulation of biological process;response to stimulus;transport	cytoplasm;extracellular;membrane	protein binding;receptor activity	SSC5D			Scavenging by Class B Receptors	0.44933327	0.003602265	0.008222717	FDR <= 0.01	15.59951127	15.5813525	15.48776571	15.61367627	15.46088902	15.6987662	16.25964921	16.07214735	15.84441798	16.11488037
P23470	474	P23470;P23470-2	PTPRG	Receptor-type tyrosine-protein phosphatase gamma OS=Homo sapiens OX=9606 GN=PTPRG PE=1 SV=4	2	2	8	metabolic process;regulation of biological process;response to stimulus	membrane	catalytic activity;protein binding;receptor activity;signal transducer activity	PTPRG				-0.3320358	0.014398709	0.027246788	FDR <= 0.05	14.71911343	14.86765083	14.59811842	14.54376792	14.70005103	14.52271052	14.22999075	14.4974682	14.38315743	14.13519573
P60900	426	G3V5Z7;G3V295;P60900;P60900-2	PSMA6	Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1	2	2	8	metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;nucleotide binding;protein binding;RNA binding	PSMA6	Proteasome Degradation	Proteasome	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	0.286737405	0.097955974	0.139771413	FDR > 0.05	17.50682077	17.68864028	17.44346221	17.63216075	17.40677001	17.86602115	17.64242748	17.91489631	18.28726725	17.40092885
A0A140T953	74	A0A140T9S9;A0A140T953;S6AU73;A0A140T9G0;D9J307	HLA-B	HLA class I histocompatibility antigen, B alpha chain (Fragment) OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=1	2	2	7				MICA				-0.603160965	0.016755278	0.030851785	FDR <= 0.05	14.5363905	14.23453883	14.61935672	14.52051992	14.38663759	13.57287805	14.06797268	14.6175728	13.50787375	13.51534145
Q96S96	730	Q96S96	PEBP4	Phosphatidylethanolamine-binding protein 4 OS=Homo sapiens OX=9606 GN=PEBP4 PE=1 SV=3	2	2	14		vacuole	protein binding	PEBP4				-1.273920099	0.000137275	0.000490837	FDR <= 0.01	17.65318283	17.75154521	17.55434785	17.69006324	17.53084245	16.59807878	16.6697934	15.63170458	16.88958508	16.02121926
A0A075B6H7	174	A0A075B6H7	IGKV3-7	Probable non-functional immunoglobulin kappa variable 3-7 OS=Homo sapiens OX=9606 GN=IGKV3-7 PE=1 SV=1	2	2	12	response to stimulus							0.564102734	0.000303866	0.000988771	FDR <= 0.01	16.64374804	16.78358371	16.65081025	16.73844349	16.90849378	17.30550295	17.23303716	17.15278291	17.29931311	17.5549568
A0A0B4J1R4	330	A0A0B4J1R4;P32754;P32754-2	HPD	4-hydroxyphenylpyruvate dioxygenase OS=Homo sapiens OX=9606 GN=HPD PE=1 SV=1	2	2	8	metabolic process	endoplasmic reticulum;Golgi;membrane	catalytic activity;metal ion binding					-0.608135162	0.000918873	0.002500472	FDR <= 0.01	17.32979313	17.48038902	17.41758814	17.39712056	17.47502314	17.17256191	16.86899679	16.93149489	16.55768305	16.52850155
P07384	684	P07384	CAPN1	Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1	2	2	8	cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport	cytoplasm;cytosol;extracellular;membrane;mitochondrion;vacuole	catalytic activity;metal ion binding;protein binding	CAPN1	Integrin-mediated Cell Adhesion; Alzheimers Disease; Focal Adhesion	Apoptosis; Alzheimer's disease; Protein processing in endoplasmic reticulum	Degradation of the extracellular matrix; Formation of the cornified envelope; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	0.50153635	0.009398361	0.018827336	FDR <= 0.05	18.17336178	18.23163075	18.06179148	18.18230747	18.03620524	18.42561307	18.68398102	18.60136755	19.18892344	18.2930934
O75083	627	O75083;D6RD66	WDR1	WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4	3	3	6	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport	cytoplasm;cytoskeleton;cytosol;extracellular	protein binding	WDR1	Hypertrophy Model		Platelet degranulation	0.110902515	0.561547284	0.618909641	FDR > 0.05	16.3316532	16.70923469	16.57962741	16.7591395	16.70341936	16.404372	16.68860287	16.31356065	17.26345859	16.96759262
P29401	320	P29401;P29401-2	TKT	Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3	2	2	4	metabolic process;regulation of biological process	cytosol	catalytic activity;metal ion binding;protein binding	TKT	Pentose Phosphate Pathway	Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Pentose phosphate pathway	Insulin effects increased synthesis of Xylulose-5-Phosphate; Pentose phosphate pathway (hexose monophosphate shunt)	1.257222737	1.09e-07	3.04e-06	FDR <= 0.01	15.6982303	15.50833753	15.59626042	15.4419732	15.67704322	16.82387095	16.85657159	16.72347382	16.77787285	17.02616914
P01602	147	P01602	IGKV1-5	Immunoglobulin kappa variable 1-5 OS=Homo sapiens OX=9606 GN=IGKV1-5 PE=1 SV=2	2	2	93	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGKV1-5			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.463933124	0.071301778	0.106952667	FDR > 0.05	22.98536134	22.98505483	22.82785832	22.98362928	22.82170803	24.06957406	23.58535406	23.63773003	22.77975028	22.85086899
H9KV31	529	O15394;H9KV31	NCAM2	Neural cell adhesion molecule 2 OS=Homo sapiens OX=9606 GN=NCAM2 PE=1 SV=2	3	3	9		membrane	protein binding					-0.613805527	0.000450323	0.001337916	FDR <= 0.01	17.36558649	17.63431275	17.53149253	17.68541951	17.6178506	17.20202931	17.10442801	16.91222292	16.87038668	16.67656732
H0Y586	447	H0Y586;O14818;O14818-2	PSMA7	Proteasome subunit alpha type-7 (Fragment) OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1	3	3	9	metabolic process	cytoplasm;proteasome	catalytic activity					0.589693523	9.14e-05	0.000346832	FDR <= 0.01	17.37013249	17.56436473	17.54789929	17.53797039	17.42268232	18.03106207	18.18808131	18.19908467	18.03980649	17.93348229
P41159	444	P41159	LEP	Leptin OS=Homo sapiens OX=9606 GN=LEP PE=1 SV=1	2	2	8	cell communication;cell differentiation;metabolic process;regulation of biological process;reproduction;response to stimulus;transport	cytoplasm;extracellular	protein binding	LEP	AMP-activated Protein Kinase (AMPK) Signaling; Leptin signaling pathway; Adipogenesis; Spinal Cord Injury; Differentiation of white and brown adipocyte; Transcription factor regulation in adipogenesis; Leptin and adiponectin; Leptin Insulin Overlap	AMPK signaling pathway; Cytokine-cytokine receptor interaction; Adipocytokine signaling pathway; Jak-STAT signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Neuroactive ligand-receptor interaction	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; Transcriptional regulation of white adipocyte differentiation; Signaling by Leptin	-1.492661747	0.000433051	0.001292845	FDR <= 0.01	14.35469679	15.21718794	15.14719351	15.04771154	15.43296257	12.76433773	13.00983017	14.10476734	13.88088623	13.97662215
P58166	534	P58166;F8VNP4	INHBE	Inhibin beta E chain OS=Homo sapiens OX=9606 GN=INHBE PE=1 SV=1	2	2	8	regulation of biological process;response to stimulus	extracellular	protein binding	INHBE		Cytokine-cytokine receptor interaction; Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway	Glycoprotein hormones	-0.507264261	0.012711777	0.024739692	FDR <= 0.05	17.88221529	17.7770717	17.77072766	17.85076847	17.66729831	17.51458252	17.30394536	17.77018426	16.91029496	16.91275302
A0A0C4DH35	538	A0A0C4DH35	IGHV3-35	Probable non-functional immunoglobulin heavy variable 3-35 OS=Homo sapiens OX=9606 GN=IGHV3-35 PE=1 SV=1	2	2	52	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus		protein binding	IGHV3-35				0.900740051	0.15316897	0.201279736	FDR > 0.05	21.31543392	21.27652187	21.1058879	21.3052637	21.00650657	22.20945602	20.9479239	24.5517585	20.89003732	21.91413846
P32004	235	P32004;P32004-3;P32004-2	L1CAM	Neural cell adhesion molecule L1 OS=Homo sapiens OX=9606 GN=L1CAM PE=1 SV=2	2	2	8	cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus	cell surface;membrane	protein binding	L1CAM		Cell adhesion molecules (CAMs); Axon guidance	Basigin interactions; Signal transduction by L1; Recycling pathway of L1; Interaction between L1 and Ankyrins	-0.097512687	0.440040857	0.514496439	FDR > 0.05	15.22214483	15.25246678	15.38906571	15.19894327	15.33091734	15.25137552	14.95220568	14.93886189	15.42029177	15.34323965
Q5TA01	2	P78417-3;P78417-2;P78417;Q5TA02;Q5TA01	GSTO1	Glutathione S-transferase omega-1 (Fragment) OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=1	3	3	12	metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol	antioxidant activity;catalytic activity;protein binding	GSTO1	Myometrial Relaxation and Contraction Pathways; Metapathway biotransformation			-0.100723943	0.443555181	0.517621321	FDR > 0.05	17.46317095	17.6747547	17.44740165	17.64277567	17.45149072	17.69353721	17.30910633	17.25781331	17.67167782	17.24383931
P00441	264	P00441;H7BYH4	SOD1	Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2	2	2	8	cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen;vacuole	antioxidant activity;catalytic activity;metal ion binding;protein binding	SOD1	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Association Between Physico-Chemical Features and Toxicity Associated Pathways; One carbon metabolism and related pathways; Oxidative Stress	Prion diseases; Amyotrophic lateral sclerosis (ALS); Longevity regulating pathway - multiple species; Huntington's disease; Peroxisome	Platelet degranulation ; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species	0.295875024	0.275860377	0.342044621	FDR > 0.05	17.22029714	17.1765566	16.99476012	17.40585469	17.10901916	16.85536155	18.34824725	17.51368865	17.72976398	16.93880139
P08294	594	P08294	SOD3	Extracellular superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD3 PE=1 SV=2	2	2	8	metabolic process;response to stimulus	cytoplasm;extracellular;nucleus;organelle lumen	antioxidant activity;catalytic activity;metal ion binding;protein binding	SOD3	Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; NRF2 pathway; Copper homeostasis; One carbon metabolism and related pathways; Oxidative Stress		Detoxification of Reactive Oxygen Species	0.678701103	0.003683125	0.008327653	FDR <= 0.01	16.20111734	16.3659745	16.45261512	16.36100316	16.88519679	17.23409515	17.1149951	16.63452483	17.57608253	17.0997148
P14209	678	P14209;P14209-3	CD99	CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1	2	2	8	regulation of biological process	cytoplasm;membrane	protein binding	CD99		Cell adhesion molecules (CAMs); Leukocyte transendothelial migration	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall	0.637503776	0.00011302	0.000413735	FDR <= 0.01	16.12428938	16.0890507	15.95397312	16.02268069	16.02106677	16.66351715	16.85171728	16.70851012	16.39605115	16.77878384
G3V4U0	23	Q9UBX5;G3XA98;G3V4U0	FBLN5	Fibulin-5 OS=Homo sapiens OX=9606 GN=FBLN5 PE=1 SV=1	3	3	11	cell organization and biogenesis		metal ion binding					0.005997613	0.982894322	0.986101155	FDR > 0.05	15.66021631	15.91372765	16.25699029	16.05561184	16.23794832	15.85706344	15.13726488	16.50951627	15.91517281	16.73546508
A0A075B6I0	78	A0A075B6I0	IGLV8-61	Immunoglobulin lambda variable 8-61 OS=Homo sapiens OX=9606 GN=IGLV8-61 PE=3 SV=7	2	2	48	response to stimulus	extracellular;membrane		IGLV8-61				0.914106401	0.003442592	0.008019674	FDR <= 0.01	22.64632163	22.51707119	22.519342	22.59171954	22.29501904	24.34756127	23.62196235	23.18991201	22.89376625	23.08680354
F5GZZ9	606	Q86VB7;Q86VB7-3;Q86VB7-2;F5GZZ9;Q86VB7-4;C9JHR8	CD163	Scavenger receptor cysteine-rich type 1 protein M130 OS=Homo sapiens OX=9606 GN=CD163 PE=1 SV=1	2	2	11	transport	membrane	receptor activity					0.254961577	0.059274345	0.092054854	FDR > 0.05	15.52288841	15.74238044	15.62323908	15.69827128	15.66999989	16.03579142	15.93813586	16.07395129	15.52833468	15.95537374
P31025	83	P31025	LCN1	Lipocalin-1 OS=Homo sapiens OX=9606 GN=LCN1 PE=1 SV=1	2	2	8	metabolic process;regulation of biological process;response to stimulus;transport	extracellular	enzyme regulator activity;metal ion binding;protein binding	LCN1			Transport of fatty acids	0.536252602	0.019903238	0.035686564	FDR <= 0.05	16.3859358	16.55014902	16.47562572	16.53328811	16.68309034	17.00855702	17.75447845	16.98205326	16.50114573	17.06311755
Q53Z42	45	A0A140T9X5;Q53Z42;A0A140T933;A0A140T9I0;A0A140T913;A0A140T955;A0A1W2PRT9;A0A1W2PPQ2	HLA-A	HLA class I antigen OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=1	2	2	11	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;endoplasmic reticulum;Golgi;membrane	protein binding;RNA binding	HLA-A; LOC100507703	Proteasome Degradation; Allograft Rejection		Interferon alpha/beta signaling; E3 ubiquitin ligases ubiquitinate target proteins; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression	-0.936615896	7.46e-05	0.00029569	FDR <= 0.01	17.67335965	17.6984275	17.67394594	17.89381295	17.79703827	16.67174439	17.26566273	16.50508281	16.99771461	16.61330026
Q5JPE7	186	Q5JPE7-2;A0A087X117;A0A087WW46;A0A7I2V6B0;A0A0G2JN29;A0A7I2V2Z5;A0A7I2V4T6;J3KN36;P69849;A0A0G2JP90;Q15155;Q5JPE7-3;Q5JPE7;A0A7I2V3P4	NOMO2	Nodal modulator 2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1	3	3	11	regulation of biological process	endoplasmic reticulum;membrane	protein binding	NOMO2				-0.635399773	0.000940528	0.002548125	FDR <= 0.01	15.46706384	15.76988814	15.80763521	15.47381856	15.58324972	14.67824088	15.06529345	15.27005612	15.13925256	14.77181359
Q9Y5Y7	95	Q9Y5Y7	LYVE1	Lymphatic vessel endothelial hyaluronic acid receptor 1 OS=Homo sapiens OX=9606 GN=LYVE1 PE=1 SV=2	2	2	8	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	membrane	protein binding;receptor activity;signal transducer activity	LYVE1			Hyaluronan uptake and degradation	-0.344749433	0.056933111	0.0890938	FDR > 0.05	16.49129214	16.98523088	16.95477841	17.014253	17.07984606	17.0055519	16.38338659	16.38514632	16.64974016	16.37782835
Q16777	13	A0A0U1RRH7;Q99878;Q7L7L0;Q16777;Q93077;P04908;Q9BTM1;H0YFX9;Q6FI13;P0C0S8;A0A0U1RR32;P20671;Q96KK5	H2AC20	Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4	2	2	8	regulation of biological process	chromosome;nucleus	DNA binding;protein binding	HIST2H2AC		Systemic lupus erythematosus; Alcoholism	SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence	0.86007825	0.283052013	0.34894784	FDR > 0.05	16.93545323	17.20152863	16.87989049	17.55417297	19.7283871	18.12177822	18.62125992	17.81535704	21.06778941	16.97363909
H7C3T4	164	Q13162;H7C3T4	PRDX4	Peroxiredoxin-4 (Fragment) OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1	2	1	8	cellular homeostasis;metabolic process;regulation of biological process		antioxidant activity;catalytic activity					0.63211204	0.00317252	0.007591828	FDR <= 0.01	13.06658013	13.39215634	12.99616998	13.50111206	13.61936252	13.96353768	13.55025222	13.86754449	14.14014485	14.214462
A0A6Q8PF80	32	A0A6Q8PHQ9;P02545-3;P02545;A0A6Q8PF80;P02545-2;P02545-6;A0A6Q8PFJ0;Q3BDU5	LMNA	Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1	2	2	8								0.598719113	0.044234018	0.071324743	FDR > 0.05	18.72855732	18.52905194	18.51942808	18.56456706	18.37582386	18.99055459	19.73923971	18.96064218	19.7681722	18.25241515
P16401	236	P16403;P16401;P10412	H1-5	Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3	2	2	11	cell organization and biogenesis;regulation of biological process	chromosome;nucleus	DNA binding;protein binding;RNA binding	HIST1H1B			Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor	0.63345012	0.19081121	0.242958372	FDR > 0.05	17.0295692	17.02272006	16.70295756	17.17799856	18.62564951	17.53832798	17.4215948	17.46838058	19.47005656	17.82778557
Q9P232	381	Q9P232	CNTN3	Contactin-3 OS=Homo sapiens OX=9606 GN=CNTN3 PE=1 SV=3	3	3	10	metabolic process	extracellular;membrane	protein binding	CNTN3			Post-translational modification: synthesis of GPI-anchored proteins	0.269670367	0.037668733	0.062107965	FDR > 0.05	17.42240616	17.46727791	17.54597644	17.54574593	17.49174012	17.8240694	17.65674697	17.81875172	17.49110148	18.03082882
A0A0A0MSQ0	435	P13797-3;P13797-2;A0A0A0MSQ0;P13797	PLS3	Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=1	2	1	8			metal ion binding;protein binding					0.042104451	0.806013936	0.837328666	FDR > 0.05	14.73100523	14.99401983	14.65074694	15.16837498	15.13026286	14.70655056	14.88556958	15.06044847	15.45442395	14.77793953
P04211	567	P04211	IGLV7-43	Immunoglobulin lambda variable 7-43 OS=Homo sapiens OX=9606 GN=IGLV7-43 PE=3 SV=2	2	1	41	cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity	IGLV7-43			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	1.589440983	0.000613866	0.001755942	FDR <= 0.01	20.62832484	20.56168502	20.47952601	20.60731931	20.30736063	23.18591893	22.54773233	21.00104348	21.9596621	21.83706389
Q8WWA0	519	Q8WWA0	ITLN1	Intelectin-1 OS=Homo sapiens OX=9606 GN=ITLN1 PE=1 SV=1	2	2	7	cell organization and biogenesis;regulation of biological process;response to stimulus	extracellular;membrane	metal ion binding;protein binding	ITLN1			Antimicrobial peptides	0.481206439	0.017712804	0.032420758	FDR <= 0.05	16.51918864	16.52789238	16.68376902	16.59177995	16.74121352	17.14804777	17.52114909	17.38016335	16.62506881	16.7954467
P15311	375	P15311;E7EQR4	EZR	Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4	3	1	12	cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;endosome;membrane	protein binding;RNA binding	EZR	Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton	Proteoglycans in cancer; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Gastric acid secretion; Regulation of actin cytoskeleton; MicroRNAs in cancer	Netrin-1 signaling; Recycling pathway of L1	-0.218130212	0.670690088	0.71486032	FDR > 0.05	13.9439397	13.91968306	13.50564125	14.61558359	13.90300881	13.18970509	14.41521047	13.74801494	15.30923575	12.13503911
Q5URX0	130	Q5URX0;P07686	HEXB	Beta-N-acetylhexosaminidase OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=1	2	2	5	cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen;vacuole	catalytic activity;protein binding	HEXB				0.056544824	0.644861126	0.692128434	FDR > 0.05	15.56400071	16.00671952	15.86287843	15.86298842	15.85699632	16.10007153	15.7433997	15.86765141	15.99890901	15.72627586
P04080	513	P04080	CSTB	Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2	2	2	7	regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;nucleus;organelle lumen	enzyme regulator activity;protein binding;RNA binding	CSTB			Neutrophil degranulation	1.066214908	0.05329548	0.084042872	FDR > 0.05	16.08124443	16.80699947	15.82343085	18.48827013	16.5818529	17.50464981	18.08558042	18.87480275	17.52588052	17.12195882
A0A494C0F5	543	Q9Y279-2;Q9Y279;Q9Y279-3;A0A494C0F5	VSIG4	V-set and immunoglobulin domain-containing protein 4 OS=Homo sapiens OX=9606 GN=VSIG4 PE=1 SV=1	2	2	13								1.125281752	5.6e-06	3.59e-05	FDR <= 0.01	15.34325426	15.43968517	15.34583102	15.39405815	14.98019645	16.27106219	16.24936423	16.37170906	16.46134572	16.77595259
O00602	283	O00602	FCN1	Ficolin-1 OS=Homo sapiens OX=9606 GN=FCN1 PE=1 SV=2	2	2	5	defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane;organelle lumen	catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity	FCN1			Ficolins bind to repetitive carbohydrate structures on the target cell surface; Neutrophil degranulation	2.538590123	3.57e-10	2.19e-07	FDR <= 0.01	18.21374641	18.25120917	17.98291352	18.06713856	18.28917594	20.66240951	20.64892186	20.62277438	20.55983783	21.00319063
P01700	674	P01700	IGLV1-47	Immunoglobulin lambda variable 1-47 OS=Homo sapiens OX=9606 GN=IGLV1-47 PE=1 SV=2	2	1	23	cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	extracellular;membrane	catalytic activity;protein binding	IGLV1-47			FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis	0.188614039	0.459073834	0.532698883	FDR > 0.05	15.25837817	15.98910265	15.66316042	15.84489627	16.10762281	16.51367754	15.25029646	16.16074189	15.67652145	16.20499319
M0QZK8	266	O75223;M0QZK8;O75223-3		Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 PE=4 SV=1	3	3	8			catalytic activity					-0.08305344	0.693449271	0.73186713	FDR > 0.05	19.39822289	19.6601297	19.66898635	19.60909093	19.81698814	18.88724993	20.00554676	19.72791242	19.85680455	19.26063714
Q96L46	711	Q96L46	CAPNS2	Calpain small subunit 2 OS=Homo sapiens OX=9606 GN=CAPNS2 PE=1 SV=2	2	2	8	cell organization and biogenesis	cytoplasm;cytosol;membrane	metal ion binding	CAPNS2			Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	0.551146151	0.014126466	0.026897141	FDR <= 0.05	15.90472831	15.91027993	15.79985103	16.15502803	15.72189962	16.5438901	16.02355925	16.51025675	17.04990771	16.11990387
Q8N0Y7	46	P18669;Q8N0Y7	PGAM4	Probable phosphoglycerate mutase 4 OS=Homo sapiens OX=9606 GN=PGAM4 PE=3 SV=1	2	2	12	metabolic process;regulation of biological process	cytosol	catalytic activity	PGAM4		Biosynthesis of amino acids; Central carbon metabolism in cancer; Glucagon signaling pathway; Carbon metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism		0.219577557	0.558405255	0.616551584	FDR > 0.05	16.59198101	16.58506871	16.62090242	16.86796749	16.95660235	16.55800893	16.43144335	16.7581137	18.53038613	16.44245766
Q16853	12	Q16853;Q16853-2	AOC3	Membrane primary amine oxidase OS=Homo sapiens OX=9606 GN=AOC3 PE=1 SV=3	2	2	12	defense response;metabolic process;regulation of biological process;response to stimulus	cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane	catalytic activity;metal ion binding;protein binding	AOC3	Amino Acid metabolism	Phenylalanine metabolism; Glycine, serine and threonine metabolism; Metabolic pathways; beta-Alanine metabolism; Tyrosine metabolism	Phase I - Functionalization of compounds	0.540434237	0.179195936	0.230555441	FDR > 0.05	14.75237299	15.24708594	15.29044026	16.09609647	15.51746551	15.73354639	15.62926628	15.85018597	17.28041015	15.11222356
Q9NZT1	496	Q9NZT1	CALML5	Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2	2	2	9	regulation of biological process;response to stimulus;transport	extracellular	metal ion binding;protein binding	CALML5	Alzheimers Disease	Circadian entrainment; Ras signaling pathway; Renin secretion; Oocyte meiosis; Vascular smooth muscle contraction; Pertussis; Glioma; cAMP signaling pathway; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; Amphetamine addiction; Alzheimer's disease; Dopaminergic synapse; Tuberculosis; Neurotrophin signaling pathway; Gastric acid secretion; Phosphatidylinositol signaling system; Estrogen signaling pathway; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Long-term potentiation; GnRH signaling pathway; Insulin signaling pathway; Melanogenesis; Olfactory transduction; Alcoholism; Phototransduction; Glucagon signaling pathway; Rap1 signaling pathway; Salivary secretion; Adrenergic signaling in cardiomyocytes; Calcium signaling pathway	Neutrophil degranulation	0.831991532	0.000123888	0.000450834	FDR <= 0.01	18.94324704	18.95415262	18.92788455	18.92225184	18.91781594	19.59132726	19.81080106	20.13426537	19.93308444	19.35583153
P0DUB6	105	P0DUB6	AMY1A	Alpha-amylase 1A OS=Homo sapiens OX=9606 GN=AMY1A PE=1 SV=1	2	2	11								1.886272827	8.98e-06	5.36e-05	FDR <= 0.01	15.65954505	15.81660976	15.90485405	16.00084778	15.95895174	17.42138779	18.72808701	17.62556106	17.32784766	17.66928899
A0A075B6J1	635	A0A075B6J1	IGLV5-37	Immunoglobulin lambda variable 5-37 OS=Homo sapiens OX=9606 GN=IGLV5-37 PE=3 SV=1	2	2	11	response to stimulus	extracellular;membrane		IGLV5-37				-0.267325557	0.118616543	0.161151203	FDR > 0.05	18.74925679	18.77301249	18.66616876	18.71841582	18.73871717	18.81673248	18.52110443	17.88273915	18.49210835	18.59625884
P25786	176	F5GX11;P25786-2;P25786	PSMA1	Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1	2	2	8	metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;nucleus;proteasome	catalytic activity;protein binding;RNA binding	PSMA1	Proteasome Degradation	Proteasome	Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis	0.431145658	0.005465696	0.011712205	FDR <= 0.05	16.81606242	16.87474146	16.99951197	17.05988164	16.88910149	17.58781512	17.29056651	17.30053805	17.56868299	17.04742461
P01137	357	A0A499FJK2;P01137	TGFB1	Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=2	2	2	13	cell death;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;extracellular;membrane;nucleus;organelle lumen	enzyme regulator activity;protein binding	TGFB1	MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Cell Cycle; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac Hypertrophic Response; Differentiation Pathway; IL-3 Signaling Pathway; Extracellular vesicle-mediated signaling in recipient cells; TGF-beta Signaling Pathway; MAPK Signaling Pathway; Endochondral Ossification; Cytokines and Inflammatory Response; ACE Inhibitor Pathway; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent)	Chronic myeloid leukemia; Endocytosis; Non-alcoholic fatty liver disease (NAFLD); Colorectal cancer; Hepatitis B; HTLV-I infection; Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Cell cycle; Pathways in cancer; Pancreatic cancer; Toxoplasmosis; Hippo signaling pathway; Inflammatory bowel disease (IBD); Intestinal immune network for IgA production; AGE-RAGE signaling pathway in diabetic complications; FoxO signaling pathway; Malaria; Leishmaniasis; Amoebiasis; Hypertrophic cardiomyopathy (HCM); Renal cell carcinoma; Dilated cardiomyopathy; Chagas disease (American trypanosomiasis); Proteoglycans in cancer; MAPK signaling pathway; Osteoclast differentiation; Rheumatoid arthritis; Tuberculosis	SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; UCH proteinases; Transcriptional regulation of white adipocyte differentiation; Downregulation of TGF-beta receptor signaling; RUNX3 regulates p14-ARF; Molecules associated with elastic fibres; Syndecan interactions; Platelet degranulation ; ECM proteoglycans; TGFBR2 MSI Frameshift Mutants in Cancer; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Cell surface interactions at the vascular wall; Regulation of RUNX3 expression and activity; Influenza Virus Induced Apoptosis; Interleukin-4 and 13 signaling; SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription	1.202936971	6.16e-05	0.000249257	FDR <= 0.01	18.61266636	18.34384437	18.27375133	18.00433369	18.20182778	20.0523699	19.54323681	19.04038537	19.25789124	19.55722506
P22692	537	P22692-2;P22692	IGFBP4	Insulin-like growth factor-binding protein 4 OS=Homo sapiens OX=9606 GN=IGFBP4 PE=1 SV=2	2	2	5	cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;organelle lumen	protein binding	IGFBP4	Myometrial Relaxation and Contraction Pathways		Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.299195391	0.036241657	0.06007714	FDR > 0.05	15.87210971	16.1223278	15.98642699	16.15975387	16.1705911	16.28773445	16.73800203	16.29009032	16.23071636	16.26064327
P25705	500	P25705;P25705-3;P25705-2	ATP5F1A	ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1	2	2	11	cell organization and biogenesis;metabolic process;regulation of biological process;transport	membrane;mitochondrion;organelle lumen	catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity	ATP5A1	Electron Transport Chain; Oxidative phosphorylation	Metabolic pathways; Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Alzheimer's disease	Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins	1.164143648	9.71e-06	5.58e-05	FDR <= 0.01	15.38411533	15.38459163	15.11633097	15.54161749	15.51348559	16.7966428	16.8887714	16.27913761	16.46029949	16.33600795
D6RGW0	20	D6RGW0;Q6P179-3;Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2 (Fragment) OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=1	2	2	7	metabolic process	endoplasmic reticulum	catalytic activity;metal ion binding					0.256561409	0.136533684	0.181749384	FDR > 0.05	17.36318421	17.53366177	17.22446062	17.36345476	17.65609084	18.13304385	17.59486805	17.73314229	17.25936358	17.70324147
O15204	470	O15204-2;O15204	ADAMDEC1	ADAM DEC1 OS=Homo sapiens OX=9606 GN=ADAMDEC1 PE=1 SV=2	2	2	8	metabolic process;regulation of biological process;response to stimulus	extracellular	catalytic activity;metal ion binding	ADAMDEC1				0.614133639	0.024902024	0.042898445	FDR <= 0.05	16.76067929	17.04583482	16.95322402	16.88329036	16.9785774	17.46903144	18.51492547	17.26899893	17.11895571	17.32036252
P24387	548	D6RHH7;P24387	CRHBP	Corticotropin-releasing factor-binding protein OS=Homo sapiens OX=9606 GN=CRHBP PE=1 SV=2	2	2	8	cell communication;defense response;regulation of biological process;response to stimulus;transport	endoplasmic reticulum;endosome;extracellular;Golgi;nucleus;vacuole	protein binding	CRHBP	Corticotropin-releasing hormone signaling pathway		Class B/2 (Secretin family receptors)	-0.384764627	0.070945575	0.106678554	FDR > 0.05	13.24759254	13.28739542	13.72510446	13.21003011	13.16083188	12.27403889	13.18900344	12.97003446	13.04648218	13.2275723
Q99715	589	A0A087X0A8;Q99715;Q99715-2;Q99715-4;D6RGG3	COL12A1	Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=2	2	2	8	cell differentiation;cell organization and biogenesis;metabolic process	extracellular;organelle lumen	protein binding;structural molecule activity	COL12A1		Protein digestion and absorption	Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization	0.251991814	0.104134619	0.145206792	FDR > 0.05	14.88433014	15.2294366	15.25494794	15.48762982	15.20192211	15.4050227	15.33819023	15.80193142	15.25457126	15.51851005
Q7Z7M8	44	Q7Z7M8	B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 OS=Homo sapiens OX=9606 GN=B3GNT8 PE=1 SV=1	2	2	7	metabolic process	Golgi;membrane	catalytic activity	B3GNT8			O-linked glycosylation of mucins	1.214783892	0.047220597	0.075234889	FDR > 0.05	15.28081566	16.13690658	15.76937935	15.83111203	15.91654345	16.07699194	19.26180746	16.00653043	16.5160055	17.1473412
P12110	102	P12110-2;P12110-3;P12110	COL6A2	Collagen alpha-2(VI) chain OS=Homo sapiens OX=9606 GN=COL6A2 PE=1 SV=4	2	2	10	cell organization and biogenesis;metabolic process;response to stimulus	extracellular;membrane;organelle lumen	protein binding	COL6A2	miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	Protein digestion and absorption; PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction	ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF	0.498522532	0.003490083	0.008069177	FDR <= 0.01	16.88848206	17.02833535	16.80327159	17.07484323	16.99942834	17.37251332	17.90187421	17.32685947	17.28101421	17.404712
A0A0G2JMX5	231	O75023-3;A0A0G2JMX5;O75023;A0A0G2JNY7;A0A0G2JPM8;O75023-2;A0A0G2JNP3	LILRB5	Leukocyte immunoglobulin-like receptor subfamily B member 5 OS=Homo sapiens OX=9606 GN=LILRB5 PE=1 SV=1	2	2	8		membrane	protein binding					-0.300449843	0.074212995	0.109978294	FDR > 0.05	16.53428967	16.690745	16.63445505	16.75322909	16.61847904	16.14969966	16.09134006	16.79800708	16.11158329	16.57831855
J3KPA1	317	P54108;P54108-3;J3KPA1;P54108-2	CRISP3	Cysteine-rich secretory protein 3 OS=Homo sapiens OX=9606 GN=CRISP3 PE=1 SV=1	2	2	11		extracellular;membrane						0.695092844	0.000267161	0.000886166	FDR <= 0.01	18.65635364	18.42767973	18.41439597	18.74390469	18.49398357	19.29743608	19.41447736	18.96918908	19.05558197	19.47509732
Q8WUA8	16	Q8WUA8	TSKU	Tsukushi OS=Homo sapiens OX=9606 GN=TSKU PE=1 SV=3	2	2	8	cell organization and biogenesis;regulation of biological process;response to stimulus	extracellular;membrane	protein binding;receptor activity;signal transducer activity	TSKU	Ectoderm Differentiation			-0.365317646	0.001668945	0.004241326	FDR <= 0.01	16.36569951	16.5100777	16.38689605	16.45025945	16.55310458	16.14165108	16.12111919	16.10672314	16.02128066	16.04867499
P00558	364	P00558-2;P00558	PGK1	Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3	2	2	12	cell differentiation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;cytosol;membrane	catalytic activity;nucleotide binding;protein binding	PGK1	Cori Cycle; Photodynamic therapy-induced HIF-1 survival signaling; Glycolysis and Gluconeogenesis	Biosynthesis of amino acids; HIF-1 signaling pathway; Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism	Gluconeogenesis; Glycolysis	0.902677424	0.003485689	0.008069177	FDR <= 0.01	17.25675107	17.25427949	17.12852136	17.43987797	17.4622881	17.94273245	18.4101276	17.6841141	19.1149452	17.90318575
A0A2R8Y7I7	351	P48637;A0A2R8Y5T7;A0A2R8Y430;A0A2R8Y7I7	GSS	Glutathione synthase (Fragment) OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1	2	2	8								0.022525881	0.823997257	0.853128473	FDR > 0.05	17.22297168	17.27969884	17.27182132	17.27696139	17.30133634	17.29192142	17.36968706	17.23993127	17.4811534	17.08272582
P62937	498	P62937;P62937-2	PPIA	Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2	2	2	8	cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;protein binding;RNA binding	PPIA	Prolactin Signaling Pathway		Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling	-0.067548058	0.817330994	0.847653561	FDR > 0.05	18.15770972	18.00884824	18.13357498	18.32394956	18.16815317	17.93847732	17.93713091	17.81325638	19.29022927	17.47540149
Q5T750	623	Q5T750	XP32	Skin-specific protein 32 OS=Homo sapiens OX=9606 GN=XP32 PE=1 SV=1	2	2	5	cell differentiation;metabolic process	cytoplasm;cytoskeleton	structural molecule activity	C1orf68				0.794431973	0.104115174	0.145206792	FDR > 0.05	16.69731838	16.74310856	16.00731258	15.87973732	15.68528784	17.32270376	17.77075301	16.80025738	17.77735512	15.31385528
O75635	25	O75635;O75635-2;C9JM00	SERPINB7	Serpin B7 OS=Homo sapiens OX=9606 GN=SERPINB7 PE=1 SV=1	2	2	5	regulation of biological process	cytoplasm	enzyme regulator activity	SERPINB7				0.439518843	0.117629318	0.160403615	FDR > 0.05	16.80313086	16.99140059	16.609167	16.77776923	16.51712853	16.85292678	17.84589384	17.43335013	17.46173382	16.30228584
Q9NYU2	641	Q9NYU2;Q9NYU2-2	UGGT1	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3	2	2	5	metabolic process;regulation of biological process;response to stimulus	endoplasmic reticulum;organelle lumen	catalytic activity;protein binding	UGGT1		Protein processing in endoplasmic reticulum	ER Quality Control Compartment (ERQC)	0.70253521	0.01410242	0.026897141	FDR <= 0.05	13.74404753	13.80890874	13.59828697	13.7100356	13.52590779	14.02854685	14.3337069	15.31908581	13.83667879	14.38184432
Q96DR8	288	A0A087WWF8;F8VV13;Q96DR8	MUCL1	Mucin-like protein 1 OS=Homo sapiens OX=9606 GN=MUCL1 PE=1 SV=1	2	2	26	metabolic process;regulation of biological process;response to stimulus	extracellular;membrane;organelle lumen		MUCL1			Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC); Dectin-2 family; Defective GALNT12 causes colorectal cancer 1 (CRCS1); Termination of O-glycan biosynthesis; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	0.565289151	0.00334823	0.007835561	FDR <= 0.01	20.02352468	19.98078186	19.97570388	20.45635762	20.13049447	20.64939278	21.06253918	20.76534679	20.548092	20.36793751
P22528	326	P22528;P35321	SPRR1B	Cornifin-B OS=Homo sapiens OX=9606 GN=SPRR1B PE=1 SV=2	2	2	11	cell death;cell differentiation;metabolic process	cytoplasm;cytoskeleton;cytosol	protein binding;structural molecule activity	SPRR1B			Formation of the cornified envelope	0.349424681	0.396964327	0.471962437	FDR > 0.05	20.50254235	19.19986258	19.49351423	20.29777928	19.20797423	19.72373654	20.60079904	21.09588259	19.95701547	19.07136244
A0A7I2V2G2	301	D6RCD7;A0A7I2V2G2;P38646;A0A7I2V2S7	HSPA9	Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=4 SV=1	2	1	9								1.220871375	0.001066585	0.002851955	FDR <= 0.01	14.88521891	15.1499711	15.2141442	15.18724995	15.22298041	16.78944719	17.29940606	15.98782784	15.91794752	15.76929282
A0A0C4DH39	296	A0A0C4DH39	IGHV1-58	Immunoglobulin heavy variable 1-58 OS=Homo sapiens OX=9606 GN=IGHV1-58 PE=3 SV=1	2	2	4	cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus	extracellular;membrane	protein binding	IGHV1-58				0.127324703	0.497603884	0.56151631	FDR > 0.05	18.38783711	18.56317214	18.2001649	18.1161774	18.07123979	18.48809541	17.92443062	18.93339145	18.27042557	18.35887181
P48723	136	P48723	HSPA13	Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1	2	2	8	cell organization and biogenesis	endoplasmic reticulum	nucleotide binding;protein binding	HSPA13			Regulation of HSF1-mediated heat shock response	-0.776245594	7.25e-05	0.000291509	FDR <= 0.01	14.67157442	15.09338367	14.93973376	14.95953399	14.81172809	13.88942367	13.98083246	14.35730581	14.21129759	14.15586643
P52209	664	P52209-2;P52209	PGD	6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3	2	2	7	metabolic process	cytoplasm;cytosol;nucleus	catalytic activity	PGD	Pentose Phosphate Pathway; NRF2 pathway	Pentose phosphate pathway; Carbon metabolism; Metabolic pathways; Glutathione metabolism	Pentose phosphate pathway (hexose monophosphate shunt)	0.141888811	0.607212768	0.662234127	FDR > 0.05	12.41272758	12.58411069	12.81006401	12.9849124	13.06624563	12.15347078	13.10796369	12.87394061	13.78100034	12.65112894
P13639	551	P13639	EEF2	Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4	2	2	8	cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome	catalytic activity;nucleotide binding;protein binding;RNA binding	EEF2	Translation Factors; AMP-activated Protein Kinase (AMPK) Signaling; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	AMPK signaling pathway; Oxytocin signaling pathway	Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin	0.505728823	0.187263263	0.239931056	FDR > 0.05	15.30008895	14.55589319	14.47830633	15.10589692	14.42938419	14.67220297	15.86104011	15.31168326	16.25095344	14.30233391
O60259	467	O60259-2;O60259	KLK8	Kallikrein-8 OS=Homo sapiens OX=9606 GN=KLK8 PE=1 SV=1	2	2	8	cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus	cytoplasm;extracellular	catalytic activity;protein binding	KLK8	Spinal Cord Injury		Formation of the cornified envelope	0.305144256	0.040804959	0.066389021	FDR > 0.05	16.00235542	16.09242123	16.07843371	16.15665781	16.04875576	16.29096418	16.78100738	16.41916656	16.35678617	16.05642093
P55285	403	D6RF86;P55285;P55285-2	CDH6	Cadherin-6 OS=Homo sapiens OX=9606 GN=CDH6 PE=1 SV=1	2	2	8	cell organization and biogenesis;regulation of biological process;response to stimulus	membrane	metal ion binding	CDH6	Neural Crest Differentiation; Ectoderm Differentiation; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition		Adherens junctions interactions	-2.228259991	2e-06	1.67e-05	FDR <= 0.01	14.47412726	15.01882075	15.09670053	15.17802798	15.24011254	12.30583719	12.42444395	12.80260548	13.57368386	12.75991861
P22392	662	Q32Q12;P22392;P22392-2	NME2	Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1	2	2	8	cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen	catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding	NME2; NME1-NME2	Nucleotide Metabolism	Metabolic pathways; Pyrimidine metabolism; Purine metabolism	Interconversion of nucleotide di- and triphosphates; Neutrophil degranulation	0.539982275	0.056425163	0.088524172	FDR > 0.05	16.78824091	16.54098883	16.5196869	16.92257798	16.4843915	16.98827922	16.90748459	17.02473786	18.22776764	16.80752819
A0A7I2V348	80	P05556-4;P05556-2;P05556-5;P05556-3;H7C4K3;E7EUI6;A0A7I2V348;C9JPK5;A0A7I2V2F9;P05556	ITGB1	Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=4 SV=1	2	2	6								-0.393567649	0.000911363	0.002491059	FDR <= 0.01	17.8617588	17.91003223	17.84170353	17.84194921	17.86246426	17.38753344	17.40861607	17.60159533	17.48565676	17.46666819
Q8TAQ9	206	H7BZA7;A0A0A0MSG9;Q8TAQ9-2;Q8TAQ9-3;Q8TAQ9	SUN3	SUN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SUN3 PE=1 SV=4	2	2	16	cell organization and biogenesis	membrane;nucleus	protein binding	SUN3				1.163725883	0.000164331	0.000580825	FDR <= 0.01	22.15365721	22.18704901	22.02305035	22.0346215	21.94157695	23.29232196	24.00926532	22.75789249	22.9834551	23.11564956
Q15149	271	Q15149-9;Q15149-7;Q15149-8;Q15149-2;Q15149-4;Q15149;Q15149-6;Q15149-3;Q15149-5	PLEC	Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3	2	2	8	cell organization and biogenesis	cytoplasm;cytoskeleton;cytosol;membrane	protein binding;RNA binding;structural molecule activity	PLEC			Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly	0.490179438	0.004044945	0.009045967	FDR <= 0.01	15.92627609	15.67829563	15.7305534	15.946253	15.4985221	16.29479969	16.32523838	16.31308376	16.41412855	15.88354704
Q13508	232	Q5J1K9;Q13508-2;Q13508;Q13508-3	ART3	Ecto-ADP-ribosyltransferase 3 OS=Homo sapiens OX=9606 GN=ART3 PE=1 SV=2	2	2	10	metabolic process	extracellular;membrane	catalytic activity	ART3			Post-translational modification: synthesis of GPI-anchored proteins	-1.759289311	5.55e-08	2.55e-06	FDR <= 0.01	17.49961443	17.49852408	17.56136435	17.52082322	17.39025195	15.60208971	15.69528024	15.42172924	16.1189711	15.83606118
P80511	26	P80511	S100A12	Protein S100-A12 OS=Homo sapiens OX=9606 GN=S100A12 PE=1 SV=2	2	2	12	cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport	cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen	metal ion binding;protein binding	S100A12			TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.508904556	0.381563078	0.455652996	FDR > 0.05	17.2546223	17.31026843	17.22551895	17.46267162	19.79355665	17.84091803	18.31063131	17.76803898	19.84967767	17.82189473
A0A3B3ISD1	59	P11362-9;P11362-8;P11362-7;P11362-12;P11362-13;P11362-21;P11362-6;P11362-11;A0A3B3ISD1;P11362-4;P11362-14;P11362-5;P11362-10;P11362-20;P11362-2;P11362;P11362-3	FGFR1	Fibroblast growth factor receptor OS=Homo sapiens OX=9606 GN=FGFR1 PE=1 SV=1	2	2	7								0.101150002	0.459021362	0.532698883	FDR > 0.05	15.70885408	15.93979341	15.89226809	15.99443633	16.05652088	16.29077318	15.70572138	15.89236006	16.20404691	16.00472127
Q9UKX5	242	Q9UKX5-2;Q9UKX5	ITGA11	Integrin alpha-11 OS=Homo sapiens OX=9606 GN=ITGA11 PE=1 SV=2	2	2	8	cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus	membrane	metal ion binding;protein binding;receptor activity;signal transducer activity	ITGA11	Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	Regulation of actin cytoskeleton; PI3K-Akt signaling pathway; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); ECM-receptor interaction; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Integrin cell surface interactions	-0.728715176	0.001377758	0.003575196	FDR <= 0.01	13.89048943	13.77152757	13.55696393	13.53709629	13.76257906	12.53941637	13.03903027	12.80222094	13.50490744	12.98950538
P08238	315	P08238	HSP90AB1	Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4	2	2	6	cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport	cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen	enzyme regulator activity;nucleotide binding;protein binding;RNA binding	HSP90AB1	NRF2 pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	NOD-like receptor signaling pathway; Estrogen signaling pathway; Pathways in cancer; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Progesterone-mediated oocyte maturation; PI3K-Akt signaling pathway; Prostate cancer	Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint	1.477288213	0.000580219	0.001667451	FDR <= 0.01	14.57186643	14.81901599	14.78765048	14.54067475	14.29630689	16.86460976	15.69179002	16.83989879	15.25735742	15.74829962
H0YNG5	159	A0A0C4DGL1;P49641-1;H0YLB9;P49641-2;P49641;H0YNG5	MAN2A2	Alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2A2 PE=1 SV=1	2	2	7	metabolic process	membrane	catalytic activity;metal ion binding	MAN2A2				-0.2517011	0.335394441	0.407643441	FDR > 0.05	16.87155615	16.96720418	16.9641544	16.92986816	16.8182594	17.28491673	17.16855756	15.78150772	16.60473367	16.45282111
P13473	24	P13473;P13473-2;P13473-3	LAMP2	Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2	2	2	9	cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport	endosome;membrane;organelle lumen;vacuole	protein binding	LAMP2	Senescence and Autophagy in Cancer	Tuberculosis; Phagosome; Lysosome	Platelet degranulation ; Neutrophil degranulation	-0.782391098	9.52e-06	5.56e-05	FDR <= 0.01	19.01543344	19.09105859	19.00458556	19.07971104	18.96272935	18.15737187	18.38527342	18.14431613	18.4253452	18.12925586
P05120	299	P05120	SERPINB2	Plasminogen activator inhibitor 2 OS=Homo sapiens OX=9606 GN=SERPINB2 PE=1 SV=2	2	2	8	regulation of biological process;response to stimulus	cytoplasm;extracellular;membrane	enzyme regulator activity	SERPINB2	Blood Clotting Cascade; Aryl Hydrocarbon Receptor Pathway; Senescence and Autophagy in Cancer	Complement and coagulation cascades	Dissolution of Fibrin Clot; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling	0.80178392	4.24e-05	0.000181232	FDR <= 0.01	14.44110006	14.38725208	14.50317771	14.55728697	14.36376046	15.52555161	15.27488727	15.26804003	14.91282286	15.28019511
Q8WZA1	372	Q8WZA1;Q8WZA1-2	POMGNT1	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 OS=Homo sapiens OX=9606 GN=POMGNT1 PE=1 SV=2	2	2	8	metabolic process	Golgi;membrane	catalytic activity;protein binding	POMGNT1		Other types of O-glycan biosynthesis	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3; O-linked glycosylation	0.630968218	0.006657971	0.013880178	FDR <= 0.05	16.63928273	16.62859343	16.54320894	16.45085756	16.33873695	17.36839488	17.6375994	16.8244139	16.61519369	17.30991883
Q6UX06	313	Q6UX06	OLFM4	Olfactomedin-4 OS=Homo sapiens OX=9606 GN=OLFM4 PE=1 SV=1	2	2	8	cell organization and biogenesis;regulation of biological process;transport	extracellular;membrane;mitochondrion;organelle lumen;vacuole	catalytic activity;protein binding	OLFM4			Neutrophil degranulation	0.96957044	0.013211089	0.025549748	FDR <= 0.05	14.95761769	15.00092202	14.59458986	15.2208352	15.88986808	15.60411959	15.60595198	15.79073721	17.1403694	16.37050688
Q9GZT8	507	Q9GZT8-2;Q9GZT8	NIF3L1	NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2	2	2	8	cell differentiation;regulation of biological process	cytoplasm;mitochondrion;nucleus	protein binding	NIF3L1				0.626000337	0.00180989	0.004543192	FDR <= 0.01	15.11918245	15.08725549	14.97199075	14.91161923	15.08797819	15.73210364	16.18993765	15.41659005	15.43828396	15.53111251
C9JPM4	41	P18085;C9JAK5;C9JPM4	ARF4	ADP-ribosylation factor 4 (Fragment) OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=1	2	2	8	regulation of biological process;response to stimulus		catalytic activity;nucleotide binding;protein binding;signal transducer activity					0.547527128	0.086242916	0.125388637	FDR > 0.05	12.5128539	12.99728687	12.77370448	12.62409378	13.33211283	14.10835254	13.45291141	13.81263246	12.45371711	13.15007398
